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Protein Overview: FBpp0309288, t-PA

General Information:
Name(s) found: FBpp0309288 [FlyBase]
t-PA / FBpp0071270 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • type=protein; loc=X:complement(9112268..9112562,9112621..9112737,9112807..9112927,9112986..9113220,9113286..9113396,9115243..9115346,9115449..9115542,9116973..9117059); ID=FBpp0309288; name=t-PB; parent=FBgn0086367,FBtr0340327; dbxref=FlyBase:FBpp0309288,FlyBase_Annotation_IDs:CG12120-PB; MD5=8083b7dad5dd455cc826fb255c949dcc; length=387; release=r5.56; species=Dmel; [FlyBase]
  • The gene tan is referred to in FlyBase by the symbol Dmel\t (CG12120, FBgn0086367). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:9111688..9117290. It has the cytological map location 8D1. There is experimental evidence that it has the molecular function</span>: beta-alanyl-histamine hydrolase activity; hydrolase activity; beta-alanyl-dopamine hydrolase activity. There is experimental evidence that it is involved in the biological process</span>: dopamine biosynthetic process; cuticle pigmentation; histamine biosynthetic process; flight behavior; histamine metabolic process; visual perception. 26 alleles are reported. The phenotypes of these alleles are annotated with: adult cuticle; mesothoracic tergum; synaptic vesicle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 387 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDA]
    Biological Process: cuticle pigmentation [IMP]
    dopamine biosynthetic process [IDA]
    penicillin biosynthetic process [IEA]
    flight behavior [IMP]
    histamine metabolic process [IMP]
    visual perception [IMP]
    histamine biosynthetic process [IDA]
    Molecular Function: beta-alanyl-dopamine hydrolase activity [IDA][IMP]
    beta-alanyl-histamine hydrolase activity [IDA]
    hydrolase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSGKILPRR QAVPVLYTRG THYEVGFDMG RTFGSMIKNF LILSKPLNET YLPLYQSPKG  60
   61 RQIYNETLGS VKDSFPQYVR ELEGVADGAE VEFHKLFLLH LDEILPQALK HQPRSKNQPT 120
  121 GCSTIIVNQK NCRLLGHTED ALTETLNHYY FVVAHIISDK PQGKYNVKEE HFMSLCYAGH 180
  181 LPGYTMSHNH HGLVFSINTI SAELLRSGKT PRHFITRALL ATSNVDDAFR VLKDAGVGAA 240
  241 DACSINFTFL ADPRQMCYNV EMAPSPDRKN ESHLNIKEVP LGEHNYHVNQ FDRIRQDQAN 300
  301 DLMISSSISR MQTFGAYNPP MSEQDVRHML GDVSGGVYCV WRENNSCDEV VKTIAVGIFD 360
  361 LSARTISLYS DNPSETEPHC RLPLLYK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..121] MSA 1.137991 View MSA. No confident structure predictions are available.
    2 View Details [122..387] PSI-BLAST 40.522879 Crystal Structure of Conjugated Bile Acid Hydrolase from Clostridium perfringens in Complex with Reaction Products Taurine and Deoxycholate


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle