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Protein Overview: C3G-PH

General Information:
Name(s) found: C3G-PH / FBpp0289753 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene C3G is referred to in FlyBase by the symbol Dmel\C3G (CG42328, FBgn0259228). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:6675449..6697579. It has the cytological map location 6D2. There is experimental evidence that it has the molecular function</span>: Ras guanyl-nucleotide exchange factor activity. There is experimental evidence that it is involved in the biological process</span>: Ras protein signal transduction. 13 alleles are reported. The phenotypes of these alleles are annotated with: wing vein L3; rhabdomere; eye; dorsal mesothoracic disc; interommatidial bristle; anterior crossvein; eye photoreceptor cell; lens; ommatidium; pigment cell. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1571 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: regulation of small GTPase mediated signal transduction [IEA]
    Ras protein signal transduction [IMP]
    Molecular Function: Ras guanyl-nucleotide exchange factor activity [IMP][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPQFDESFLS DCALADRWHF YSYTVKQLPP HPSPKPNRNR NPYPSGASHD DHQHQLHHHH  60
   61 HQQHHHNHHR LWKTQRQSWS PRDTNNNHSL TSNNCNCNSS NTCNSISATG NTLHSIKFHR 120
  121 RRKYKKLARL ALSTPAIPLQ MDVDVDVNVT VDREFDMEMD TPVPLKNAVC HGSISSPSTP 180
  181 GTCSSGIGVG GGGCSSSSNN SINSGSYSTA CTPPPPTHQH HSQHQQLQGT PGGSSRVGGA 240
  241 GAGGGGGVPP APPSAGSSGH KNSLKGTKLA RRARSFKDDL IEKISLMRTT NNTLGRSHSP 300
  301 HSPRTKHGTK APPTTEEVLR STQTLETHVK DISNALKHFR DVILKKKLEV LPGNGTVILE 360
  361 TIASMYSVIQ TYTLNENSAI MSSATLQVYQ SLGKLIKLCD EVMLSEDSGE CASLSNENVR 420
  421 EVIDLLEDAV RNLVTLAQGK LKEQDQCAFR YSGSGLGGIG AAAEIMGAVT ASPGASVPGT 480
  481 GVMRVSAAES AAQRTSLPDI ALTPKERDIL EQHNVNPMRG SHSTESILRD TSPPPKPPLP 540
  541 NRASNPPPLP PKRRSQPSAS AGTVGVGCSS STSTSNQASP LPYAQSHNIS LNSDLDCSSN 600
  601 ISLLNYGVDR LSVRSRSPDE NSQCSFDSAL NHSREEEDQQ QQHQHLRSFP KLAAMMDEDM 660
  661 DKMVSYSAAI DDKTQTPLST GGGIAGVAGG TGGAGEGVAA AASGDGETNS NRHSNESGFV 720
  721 SMREFRTSTQ TTDYSVQSST KSSSSNSEIA FSISESTAVG SSSEYQQISQ LVSHSQRHIS 780
  781 SSSSSCTTTT TSSSTTTGYG SSEVEQLQQQ QQQQTTTTPA DLAPALPPKS IQRSSLTRHD 840
  841 SPGVGDELDE VQSSSGWASH RSSQSEVAEL RQLSPLHHLN HHPHTASAGQ LQQWHSKHHS 900
  901 LIEGPRLQLA GSGSCSAFDQ RHLDQEPPPL PIKKKHILAY MEICSASTRS IEQHRHTMHA 960
  961 CNISRNISHS QTMNIMPMSK ELSPELEMPP ALPPKNYKQR KATSMVASPT LQPVIVTTPP1020
 1021 PSPKPTLGEN GSTGRPDSRM ATVCEELNDA VASEDAMPEP RSPVLDSNEN VSAVDDGQTF1080
 1081 YCHSHQLPAA EMEMSEDASS ADNQPITTPQ VLEEQEEPTA ESRPLVAVHE SVKPANVDED1140
 1141 EEAERADMLI NMLEEVNITR YLILKKREED GPEVKGGYID ALIVHASRVQ KVADNAFCEA1200
 1201 FITTFRTFIQ PIDVIEKLTH RYTYFFCQVQ DNKQKAAKET FALLVRVVND LTSTDLTSQL1260
 1261 LSLLVEFVYQ LVCSGQLYLA KLLRNKFVEK VTLYKEPKVY GFVGELGGAG SVGGAGIAGS1320
 1321 GGCSGTAGGG NQPSLLDLKS LEIAEQMTLL DAELFTKIEI PEVLLFAKDQ CEEKSPNLNK1380
 1381 FTEHFNKMSY WARSKILRLQ DAKEREKHVN KFIKIMKHLR KMNNYNSYLA LLSALDSGPI1440
 1441 RRLEWQKGIT EEVRSFCALI DSSSSFRAYR QALAETNPPC IPYIGLILQD LTFVHVGNQD1500
 1501 YLSKGVINFS KRWQQYNIID NMKRFKKCAY PFRRNERIIR FFDNFKDFMG EEEMWQISEK1560
 1561 IKPRGRRPVN Y

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..171] FFAS03 1.09 Crystal Structure of Escherichia coli SufA Involved in Biosynthesis of Iron-sulfur Clusters
    2 View Details [172..353] FFAS03 1.0 Interaction of ERA,a GTPase protein, with the 3'minor domain of the 16S rRNA within the THERMUS THERMOPHILUS 30S subunit.
    3 View Details [354..502] deduced N/A No confident structure predictions are available.
    4 View Details [503..687] MSA 2.239988 View MSA. No confident structure predictions are available.
    5 View Details [688..775] deduced N/A No confident structure predictions are available.
    6 View Details [776..1000] MSA 1.205983 View MSA. No confident structure predictions are available.
    7 View Details [1001..1115] deduced N/A No confident structure predictions are available.
    8 View Details [1116..1571] PSI-BLAST 125.0 Crystal structure of the DH-PH-cat module of Son of Sevenless (SOS)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8
    Term Confidence Notes
  • binding
    		•  0.597587183571285 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.32323692785606 bayes_pls_golite062009
  • protein binding
    		•  0.29116370406325 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle