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Protein Overview: CG3626-PA

General Information:
Name(s) found: CG3626-PA / FBpp0070620 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG3626 (CG3626, FBgn0029706). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:4260452..4265169. It has the cytological map location 4C2. Based on sequence similarity, it is predicted to have molecular function</span>: [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: glycine catabolic process. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 939 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex [ISS]
    Biological Process: glycine catabolic process [IEA]
    Molecular Function: oxidoreductase activity [IEA]
    [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity [ISS]
    aminomethyltransferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWKLLQRSGN AVSVVPRRRW CSPGLSNAVR LSSSQMDPAD ERVLRKRKFQ PQQAADLSEE  60
   61 LAGQLPVKSR VVICGGGITG ASVAYHLGLR GWGGETLLVE QDRVGGELPW TACGLAGRFE 120
  121 PSYTELKLAE YSIDLIKRLA ENGLPTGWRP VGSLNLARSW DRMTAFNRMK SQALAWGMHC 180
  181 EILSPEQCAQ HCELLSLDGI EGGLWIPEDG VCDPQLVCQA YMIEAQRLGV RIVEHCAIKK 240
  241 IHSEHGKVRS VETTAGDVEC EYFVNCTGFW AREVGTLSKP VVKVPLKAVE HHYLHTKPIE 300
  301 GLSPDTPFVR DFDGRIFFRE CEGHILAGGF EREAKMVYED GVIPLSQTAR QHPPDWDHFH 360
  361 ELLDALLLRV PSFRDATLDR LTNSLQVFSP DCKWILGEAP EIQNYYVAAG NKTMGVSASG 420
  421 GIGRVLTDLI TKGSTYLDLH ILDISRFLGL HNNRKFLRDR CKEAPGKHFE INYPFEEFQT 480
  481 GRNLRMSPIY PQLKEAGAVF GQSMGYERPN YFDQQDKHDE FGLPRFRIAQ TRTFGKPPWF 540
  541 DHVASEYRAC RERIGIADYS SFTKYDFWSK GNEVVDLLQY LCSNDVDVAV GSIIHTGMQN 600
  601 PNGGYENDCS LARLSERHYM MIAPTIQQTR SMCWIRKHMP NHLRAKVNVA DVTSMYTAIC 660
  661 ILGPYSRILL SELTDTDLTP KSFPFFTYKE LDVGLADGIR VLNITHTGEL GYVLYIPNEY 720
  721 ALHVYSRLYQ AGQKFNIQHA GYYATRALRI EKFYAFWGQD LDTFTTPLEC GRSWRVKFNK 780
  781 PIDFIGRNAL LKQREEGVKR MYVQLLLNDH DHEVDMWCWG GEPIYRDGVY VGMTTTTGYG 840
  841 YTFEKQVCLG FVRNFDDEGR ELPVTNEYVL SGHYEVEVAG VRFEAKVNLH SPNLPTKFPD 900
  901 REREAYHATR DKPDQADLLS YGGVTTVKGT GIPTDGHGL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..939] PSI-BLAST 150.0 Crystal structure of dimethylglycine oxidase of Arthrobacter globiformis in complex with acetate

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • aminomethyltransferase activity
    		•  5.79381074929643 bayes_pls_golite062009
  • sarcosine dehydrogenase activity
    		•  3.16989177210403 bayes_pls_golite062009
  • dimethylglycine dehydrogenase activity
    		•  2.89047185292175 bayes_pls_golite062009
  • choline dehydrogenase activity
    		•  2.71076524649484 bayes_pls_golite062009
  • methyltransferase activity
    		•  2.70138650934058 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  2.61988251128991 bayes_pls_golite062009
  • catalytic activity
    		•  1.65079399897053 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  1.61125987248836 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  1.48681373014973 bayes_pls_golite062009
  • dihydrolipoyl dehydrogenase activity
    		•  1.24564487540873 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.867567984371732 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  0.550291785460228 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  0.414585119247371 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  0.414585119247371 bayes_pls_golite062009
  • transferase activity
    		•  0.217873555384951 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle