Protein Overview: trol-PA

General Information:
Name(s) found:	trol-PA / FBpp0070436 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|78706472\|ref\|NP_001027037.1\| terribly reduced optic lobes, isoform A [Drosophila melanogaster] [NCBI NR] ref\|NP_524643.2\| CG7981-PA [Drosophila melanogaster] [NCBI NR] gi\|22831580\|gb\|AAF45786.3\| terribly reduced optic lobes, isoform A [Drosophila melanogaster] [NCBI NR] The gene terribly reduced optic lobes is referred to in FlyBase by the symbol Dmel\trol (CG33950, FBgn0261451). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:2365016..2439423. It has the cytological map location 3A1-3A4. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: maintenance of epithelial cell apical/basal polarity. 171 alleles are reported. The phenotypes of these alleles are annotated with: female reproductive system; eye; dorsal mesothoracic disc; neuroblast; brain; dorsal metathoracic disc; larval brain; larval optic lobe; thoracic neuroblast; larval central nervous system. It has 8 annotated transcripts and 8 annotated polypeptides. [FlyBase] >CG7981-PA translation from_gene[CG7981 trol FBgn0001402] seq_release:3 mol_weight=461794 cds_boundaries:(X:2,227,927..2,262,115[-]) aa_length:4179 transcript_info:[CG7981-RA seq_release:3] gene_info:[gene symbol:trol FBgn0001402 gene_boundaries:(X:2,2 [hmr_yeast5_DM3-1_pombe.fasta] (Q9W4Y4) CG7981 protein [DrosMelano7227.FASTAC.txt] CG7981-PA, isoform A [Drosophila melanogaster]gi\|24158420\|ref\|NP_524643.2\| CG7981-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=X:complement(2365185..2365227,2366985..2367132,2367208..2367624,2367693..2368393,2368463..2369388,2369449..2369721,2369857..2370062,2374767..2374941,2375103..2375352,2375450..2375909,2376030..2376424,2376492..2376669,2377157..2377419,237 [fly-100309-contam.fasta] CG33950-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] terribly reduced optic lobes CG33950-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=X:complement(2365185..2365227,2366985..2367132,2367208..2367624,2367693..2368393,2368463..2369388,2369449..2369721,2369857..2370062,2374767..2374941,2375103..2375352,2375450..2375909,2376030..2376424,2376492..2376669,2377157..2377419,2377519..2378122,2378366..2378546,2378650..2378792,2380090..2380275,2380960..2382046,2382114..2384350,2384489..2384875,2386379..2386453,2386688..2386918,2387021..2387248,2387584..2387709,2388437..2388670,2389074..2389271,2389645..2389761,2389981..2390066,2390494..2390626,2390809..2390958,2391351..2391521,2392055..2392148,2392516..2392664,2393244..2393711,2394270..2394395,2394596..2394709,2394804..2394935,2395152..2395274,2395660..2395770,2399163..2399376); ID=FBpp0070436; name=trol-PA; parent=FBgn0001402,FBtr0091962; dbxref=FlyBase:FBpp0070436,FlyBase_Annotation_IDs:CG33950-PA,GB_protein:AAF45786.3,REFSEQ:NP_001027037,GB_protein:AAF45786; MD5=b64fe68ed9e42b0377890d0e21a27227; length=4179; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=X:complement(2365185..2365227,2366985..2367132,2367208..2367624,2367693..2368393,2368463..2369388,2369449..2369721,2369857..2370062,2374767..2374941,2375103..2375352,2375450..2375909,2376030..2376424,2376492..2376669,2377157..2377419,2377519..2378122,2378366..2378546,2378650..2378792,2380090..2380275,2380960..2382046,2382114..2384350,2384489..2384875,2386379..2386453,2386688..2386918,2387021..2387248,2387584..2387709,2388437..2388670,2389074..2389271,2389645..2389761,2389981..2390066,2390494..2390626,2390809..2390958,2391351..2391521,2392055..2392148,2392516..2392664,2393244..2393711,2394270..2394395,2394596..2394709,2394804..2394935,2395152..2395274,2395660..2395770,2399163..2399376); ID=FBpp0070436; name=trol-PA; parent=FBgn0001402,FBtr0091962; dbxref=FlyBase:FBpp0070436,FlyBase_Annotation_IDs:CG33950-PA,GB_protein:AAF45786.3,REFSEQ:NP_001027037,GB_protein:AAF45786; MD5=b64fe68ed9e42b0377890d0e21a27227; length=4179; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Terribly reduced optic lobes, isoform A OS=Drosophila melanogaster GN=trol PE=2 SV=3 [UniProt_drosophila_07-01-2011_reversed.fasta]
Organism:	Drosophila melanogaster
Length:	4179 amino acids
Gene Ontology:
Cellular Component:	lipid particle [IDA] basement membrane [ISS] extracellular matrix [IEA] proteinaceous extracellular matrix [NAS]
Biological Process:	maintenance of epithelial cell apical/basal polarity [IMP] asymmetric neuroblast division [NAS] cell adhesion [IEA]
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSETPDPLT PSPQPPLAND SLNNALHQGV KAQRGWMRMW NVCIFMSFVL SCHFDVDCWQ  60
   61 CLHSRKSRAK NKCQANEFRC NNGDCIDARK RCNNVSDCSE GEDENEECPA ACSGMEYQCR 120
  121 DGTRCISVSQ QCDGHSDCSD GDDEEHCDGI VPKLRYTCPK GKFTCRDLSC ISIVHRCDGR 180
  181 ADCPNDRSDE EGCPCLYDKW QCDDGTCIAK ELLCNGNIDC PEDISDERYC EGGYDSEECR 240
  241 FDEFHCGTGE CIPMRQVCDN IYDCNDYSDE VNCVEGEEED RVGIPIGHQP WRPASKHDDW 300
  301 LHEMDTSEYQ VYQPSNVYEK ANSQNPCASN QFRCTTSNVC IPLHLRCDGF YHCNDMSDEK 360
  361 SCEQYQRHTT TRRPLTLATP TSRITTQGPG LLERRNTTTA TEASRWPWAT KTTTIATTTS 420
  421 NPITTVGVAN SPPQTCLENI EFACHNRDCI SIESVCDGIP DCGRNEDEDD ALCKCSGDKY 480
  481 KCQRGGGCIP KSQVCDGKPQ CHDRSDESAC HLHGRLNKTR LGVKCLESQY QCGDGSCISG 540
  541 YKRCNGIHDC ADASDEYNCI YDYEDTYDTD PNNNPLNECD ILEFECDYSQ CLPLEKKCDG 600
  601 YADCEDMSDE LECQSYTDHC LESEFECDSY CLPRDQLCNG IPNCQDGSDE RNCTFCREDA 660
  661 YLCNTGECVA DNQRCNGIAD CADGSDERHC ARIYCPPNKL ACNGTCVSRR IKCDGIRDCL 720
  721 DGYDEMYCPE TNNHYPTQNV NVIRPKLGPN PIPKSCRPHE WQCANLECID SSLQCNEIKD 780
  781 CSDGSDEELS VCFGTATTRL KPSDCSPEQF YCDESCYNRS VRCNGHVDCS DGSDEVGCSL 840
  841 PCPQHQCPSG RCYTESERCD RHRHCEDGSD EANCTAILCK DNEFLCFDRQ FCINATQQCD 900
  901 GYYDCRDFSD EQNCIGCYAN QFRCNNGDCV SGSAPCNGYS ECSDHSDELN CGGTQECLPN 960
  961 QFRCNSGQCV SSSVRCNGRT DCQDSSDEQN CGHRHTEVSQ GLETTGVFTT STTSTTAMTP1020
 1021 LRIICPPTSF KCENGPCISL GLKCNGRVDC PYDGSDEADC GQISNDIDPA DSNDRRPNQL1080
 1081 NLKTYPDSQI IKENNDVGSR PESACTEYQA TCMNGECIDK SSICDGNPDC SDASDEQSCS1140
 1141 LGLKCQPNQF MCSNSKCVDR TWRCDGENDC GDNSDETSCD PEPSGAPCRY NEFQCRSGHC1200
 1201 IPKSFQCDNV PDCTDGTDEV GCMAPLPIRP PPQSVSLLEY EVLELTCVAT GTPTPTIVWR1260
 1261 LNWGHVPDKC ESKSYGGTGT LRCPDMRPQD SGAYSCEIIN TRGTHFVNPD TIVTVRPVRT1320
 1321 DVCEAGFFNM LARKAEECVQ CFCFGVAKAC DSANLFTYAI HPPILSHRVV SVELSPLRQI1380
 1381 VINEAAPGQD LLTLLHGVQF RATNVHFSGR ETPYLALPAD YMGNQLKSYG GNLRYEVNYR1440
 1441 GSGRPVNGPD VIITGNRFTL TYRVRTQPGQ NNRVSIPFVP GGWQKPDGRK ASREEIMMIL1500
 1501 ANVDNILIRL GYLDSTAREV DLINIALDSA GTADKGLGSA SLVEKCQCPP GYVGDSCESC1560
 1561 ASGYVRQPGG PWLGHCVPFI PDSCPSGTYG DPRRGVPCKE CPCPLTGSNN FASGCQQSPD1620
 1621 GDVVCRCNEG YTGRRCEQCA AGYQGNPLAA GGICRRIPDT SCNVDGTYSV HSNGTCQCKD1680
 1681 SVIGEQCDTC KSKSFHLNSF TYTGCIECFC SGVGLDCDSS TWYRDQVTST FGRSRVDHGF1740
 1741 VLVTNYMQPT PDTVPVSMAA EPNALSFIGS ADQSGNTLYW SLPAAFLGNK LSSYGGKLTY1800
 1801 TLSYSPLPNG IMSRNSAPDV VIKSGEDLRL IHYRKSQVVP SVANTYSVEI KESAWQRGDE1860
 1861 VVANREHVLM ALSDITAIYI KATYTTSTKE ASLRQVTLDV ATPTNLGTPR AVEVEQCRCP1920
 1921 EGYLGLSCEQ CAPGYARDPE GGIYLGLCRP CECNGHSKYC NSDTGDCEEC SDNTEGPSCE1980
 1981 RCAAGYVGDA TRGTIYDCQP DEGYPIPSPP APGNQTLECT AYCQIEGIYD CRGNECLCKR2040
 2041 NVIGDQCDQC RPGTYGLSAQ NQDGCKECYC SGLASQCRSA ALYRQLIPVD FILNAPLITD2100
 2101 ESGAVQDTEN LIPDISRNMY TYTHTSYLPK YWSLRGSVLG NQLFSYGGRL SYSLIVESYG2160
 2161 NYERGHDIVL IGNGLKLIWS RPDGNENQEE YNVRLHEDEQ WTRQDRESAR PASRSDFMTV2220
 2221 LSDLQHILIR ATPRVPTQST SIGNVILESA VTTRTPGATH ASDIELCQCP SGYVGTSCES2280
 2281 CAPLHYRDAS GSCSLCPCDV SNTESCDLVS GGYVECRCKA RWKGDRCREI DTSPIIEDPP2340
 2341 QICDLSRGFC CSGFQFDIAP NETISFNDTL QIYKGNRIIG NMTKLRYGCP SRDTNDPTDI2400
 2401 GTEDPVLTQI IVSIQKPEIT IVPVGGSMTL SCSGRMRWSN SPVIVNWYKE NSRLPENVEV2460
 2461 QGGNLYLYDL QVSDSGVYIC QAVNNETASV FKDTVSITIT KKDQLSPAEI VNLPSHVTFE2520
 2521 EYVNNEIICE VLGNPAPRVT WARVDGHADA QSTRTYDNRL IFDSPRKSDE GRYRCQAEND2580
 2581 QNRDEKYVIV YVQSNPPQPP PQQDRLYITP EEINGLAGES FQLNCQFTSV ASLRYDWSHN2640
 2641 GRSLSSSPAR NVEIRGNTLE VRDASESDSG VYTCVAYDVR TRRNFTESAR VNIDRREEQP2700
 2701 FGNKPIIESL EQNILIIQGE DYSITCEASG SPYPSIKWAK VHDFMPENVH ISGNVLTIYG2760
 2761 ARFENRGVYS CVAENDHGSD LSSTSIDIEP RERPSVKIVS APLQTFSVGA PASLYCTVEG2820
 2821 IPDPTVEWVR VDGQPLSPRH KIQSPGYMVI DDIQLEDSGD YECRAKNIVG EATGVATITV2880
 2881 QEPTLVQIIP DNRDLRLTEG DELSLTCVGS GVPNPEVEWV NEMALKRDLY SPPSNTAILK2940
 2941 IYRVTKADAG IYTCHGKNEA GSDEAHVRVE VQERRGDIGG VDDDSDRDPI NYNPPQQQNP3000
 3001 GIHQPGSNQL LATDIGDNVT LTCDMFQPLN TRWERVDGAP LPRNAYTIKN RLEIVRVEQQ3060
 3061 NLGQYRCNGI GRDGNVKTYF VKELVLMPLP RIRFYPNIPL TVEAGQNLDV HCQVENVRPE3120
 3121 DVHWSTDNNR PLPSSVRIVG SVLRFVSITQ AAAGEYRCSA FNQYGNRSQI ARVAVKKPAD3180
 3181 FHQVPQSQLQ RHREGENIQL QCTVTDQYGV RAQDNVEFNW FRDDRRPLPN NARTDSQILV3240
 3241 LTNLRPEDAG RYICNSYDVD RGQQLPEVSI DLQVLTATPP PNSPIYLPPQ LPAKSRDYSL3300
 3301 KLDDQSSNLR AGESTDVECY SSDDTYTDVV WERSDGAPLS NNVRQVGNRL VISNVSPSDA3360
 3361 GNYVCKCKTD EGDLYTTSYK LEVEDQPHEL KSSKIVYAKV GANADLQCGA DESRQPTYRW3420
 3421 SRQYGQLQAG RSLMNEKLSL DSVQANDAGT YICTAQYADG ETADFPNILV VTGAIPQFRQ3480
 3481 EPRSYMSFPT LPNSSFKFNF ELTFRPENGD GLLLFNGQTR GSGDYIALSL KDRYAEFRFD3540
 3541 FGGKPMLVRA EEPLALNEWH TVRVSRFKRD GYIQVDEQHP VAFPTLQQIP QLDLIEDLYI3600
 3601 GGVPNWELLP ADAVSQQVGF VGCISRLTLQ GRTVELIREA KYKEGITDCR PCAQGPCQNK3660
 3661 GVCLESQTEQ AYTCICQPGW TGRDCAIEGT QCTPGVCGAG RCENTENDME CLCPLNRSGD3720
 3721 RCQYNEILNE HSLNFKGNSF AAYGTPKVTK VNITLSVRPA SLEDSVILYT AESTLPSGDY3780
 3781 LALVLRGGHA ELLINTAARL DPVVVRSAEP LPLNRWTRIE IRRRLGEGIL RVGDGPERKA3840
 3841 KAPGSDRILS LKTHLYVGGY DRSTVKVNRD VNITKGFDGC ISRLYNFQKP VNLLADIKDA3900
 3901 ANIQSCGETN MIGGDEDSDN EPPVPPPTPD VHENELQPYA MAPCASDPCE NGGSCSEQED3960
 3961 VAVCSCPFGF SGKHCQEHLQ LGFNASFRGD GYVELNRSHF QPALEQSYTS MGIVFTTNKP4020
 4021 NGLLFWWGQE AGEEYTGQDF IAAAVVDGYV EYSMRLDGEE AVIRNSDIRV DNGERHIVIA4080
 4081 KRDENTAILE VDRMLHSGET RPTSKKSMKL PGNVFVGGAP DLEVFTGFRY KHNLNGCIVV4140
 4141 VEGETVGQIN LSSAAVNGVN ANVCPANDDP LGGTEPPVV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.58

Protein Overview: trol-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: