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Protein Overview: FBpp0307961, pas...

General Information:
Name(s) found: FBpp0307961 [FlyBase]
pasha-PA / FBpp0085181 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • type=protein; loc=3R:join(27444260..27444491,27444963..27445166,27445232..27446181,27446238..27446492,27446552..27446839); ID=FBpp0307961; name=pasha-PC; parent=FBgn0039861,FBtr0337032; dbxref=REFSEQ:NP_001263150,GB_protein:AGB96528,FlyBase:FBpp0307961,FlyBase_Annotation_IDs:CG1800-PC; MD5=a0fddc58f2d49fcd865991e6a744cf6a; length=642; release=r5.56; species=Dmel; [FlyBase]
  • The gene partner of drosha is referred to in FlyBase by the symbol Dmel\pasha (CG1800, FBgn0039861). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:27443699..27447197. It has the cytological map location 100D1. Based on sequence similarity, it is predicted to have molecular function</span>: double-stranded RNA binding. There is experimental evidence that it is involved in the biological process</span>: primary microRNA processing; gene silencing by miRNA; imaginal disc growth. 13 alleles are reported. The phenotypes of these alleles are annotated with: imaginal disc; larval optic lobe. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 642 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: primary microRNA processing [IMP]
    gene silencing by miRNA [IMP]
    imaginal disc growth [IMP]
    Molecular Function: double-stranded RNA binding [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEKPLADCP DSGQVRKRPR LEDEEQELKV AGFSLSAIEE MRRTRDNELQ NEPMDQQLRQ  60
   61 FQVLDEVGSG SDEDDESDNA SEQQGGRYGE GGDEEEEAAD GDGEEYDSSE FDDDEIENLL 120
  121 DEKLPEELRE SKQPKYEQRF KTVLEEKRLN HFEVLPEGWV QVTHNSGMPL FLHRKTRVCC 180
  181 ASRPYFLGTG SARKHAVPLG AIPCLNYRRA LEEESEVEQQ KTDGAPPVAV CPMAGASALP 240
  241 AEAMDVEGKE NNEGSTDSKT QPDGITALMP AAKIVTVNEN TQKESITPEQ LNTYCQKLFK 300
  301 FKVIRVLRFR SWNARRKFTK NRKHIKNIQR PTLPDGTKLI KFPILANAGE GSTNPRGRKE 360
  361 WIMNPNGKSF VCILHEYVQH ALKTQPTYEF KELQNAATPY SATVSVNNLK YGTGYGTSKK 420
  421 QAKSEAARET LEILIPDVKD KITGNNKDQK SGTAKKAQSD LSVFDDIRIE DPRVTEFCNK 480
  481 TTEPSPNAIL LTCLQRNYGS DVQISQEINR TANNKNEFTM TVGKHTAKVV CKNKREGKQL 540
  541 ASQAILQILH PHIQTWGSLL RLYGNNSIKT FKEKKLEEQE ITVLQSKAAV NQPNYAILDK 600
  601 LKSEMLKLCA KQESVLTMGT FVPPSDVDLP TSSGSNLNNV EL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..148] MSA 2.01598 View MSA. No confident structure predictions are available.
    2 View Details [149..277] MSA 2.078992 View MSA. No confident structure predictions are available.
    3 View Details [278..367] PSI-BLAST 20.69897 RNase III endonuclease catalytic domain; RNase III, C-terminal domain
    4 View Details [368..642] PSI-BLAST 50.0 No description for 2yt4A was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle