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Protein Overview: Aph-4-PA

General Information:
Name(s) found: Aph-4-PA / FBpp0085095 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Alkaline phosphatase 4 is referred to in FlyBase by the symbol Dmel\Aph-4 (CG1462, FBgn0016123). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26874654..26878268. It has the cytological map location 100B1. Based on sequence similarity, it is predicted to have molecular function</span>: alkaline phosphatase activity. There is experimental evidence that it is involved in the biological process</span>: epithelial fluid transport; nervous system development. 5 alleles are reported. The phenotype of these alleles is annotated with: adult Malpighian tubule. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 596 amino acids

    Gene Ontology:
    Cellular Component: anchored to plasma membrane [ISS]
    Biological Process: metabolic process [IEA]
    nervous system development [IEP]
    epithelial fluid transport [IMP]
    Molecular Function: alkaline phosphatase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHCLVILGFL LGSLVAFSWA GVTTQPPPLI RTLSAGGDIG PQFDVGKTKE PEDAEFWHNV  60
   61 GLRQLEKTIK QAQRVKEDSY QKKARNIIIF IGDGMGISTI SAGRIYKGQY LKHGYGEEET 120
  121 LVFDDFPNTG MAKTYNVDKQ VPDSAGTATA IFSGSKTHYG AIGMDATRSK KNGQQGRVQS 180
  181 VMEWAQKEGK RTGVVTTTRI THATPAATYA HIYDRDWECD TEVPAESVGF HVDIARQLVE 240
  241 NAPGNRFNVI LGGGMSPMGI LNASEVKTTI FEGPTETICT RGDNRNLPAE WLAHHANDTV 300
  301 PPALVHNRKD LLNVNVKKVD HLMGLFRNNH ITYSIAREAG EPSLQEMTET ALGILERGDE 360
  361 SNGFVLLVEG GRIDQGHHMN YARAALHELY EFDLAIQAAV NNTDPDETLI LVTADHSHAV 420
  421 TFNGYALRGA DILGTANSHE KNDPMFYETI SYANGPGYWD HLANDSRPQN SSNMWMPLKH 480
  481 FTAEERAAPT YRHLATVPRK DETHGGEDVA VFAYGPGSSL IRGVFEQNYL AYVMSYAGCL 540
  541 GPAKDFDDSC EDHKDGQKDR PLDKPNPKRN GATVVGASLI PILTAATAAI LRGRGL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..596] PSI-BLAST 156.0 X-ray structure of alkaline phosphatase from human placenta in complex with 5'-AMP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity, acting on ester bonds
    		•  2.8318172470006 bayes_pls_golite062009
  • hydrolase activity
    		•  2.68329882022147 bayes_pls_golite062009
  • catalytic activity
    		•  2.31328968099128 bayes_pls_golite062009
  • phosphatase activity
    		•  1.51067400873904 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  1.32325931665891 bayes_pls_golite062009
  • alkaline phosphatase activity
    		•  0.688134376880261 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.515209766971615 bayes_pls_golite062009
  • kinase activity
    		•  0.503509300116176 bayes_pls_golite062009
  • binding
    		•  0.48922825585019 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.356909797780746 bayes_pls_golite062009
  • protein binding
    		•  0.208332656410563 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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