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Protein Overview: tmod-PA

General Information:
Name(s) found: tmod-PA / FBpp0085024 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene tropomodulin is referred to in FlyBase by the symbol Dmel\tmod (CG1539, FBgn0082582). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26358336..26404627. It has the cytological map location 99F7-99F8. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: cytoskeleton organization. 24 alleles are reported. The phenotypes of these alleles are annotated with: striated muscle thin filament; indirect flight muscle. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 367 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [IEA]
    Biological Process: cytoskeleton organization [ISS]
    Molecular Function: actin binding [ISS]
    tropomyosin binding [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METSATTKTT TLTTPAKLYG KDLSEYDDVD VESLLAQLSP EEITILAKEV DPDDNFLPPD  60
   61 QRNSYECTKE ATGPLNRKQL IEHINKQAIE TPDQPEFEPF VQGKVRGKKW VPPPRDARDI 120
  121 EAEEQIAIDM GEEYEHALND ATQEEIIDLA AILGFHSMMN QDQYHASLLN KGQPVGLGWD 180
  181 GITKSTQQKL FPMDPPNNTD VEESIKRVKD DDSKLIDLNL NNIKNISDEK LEQLFAALPQ 240
  241 NEHLEVLSLT NVGLTDKTAL LLAAAIEKSK TLRVLNVETN FISPPVIVKL VQALLKCHTI 300
  301 EEFRASNQRS AVLGNKIEME ITDLVEKNSS LLRLGLHLEF NDARHRVAAH LQRNIDRIRV 360
  361 KRLNQRK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..173] Pfam 7.744727 No description for PF03250.5 was found. No confident structure predictions are available.
    2 View Details [174..367] PSI-BLAST 23.39794 Tropomodulin C-terminal domain


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle