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Protein Overview: MED25-PA

General Information:
Name(s) found: MED25-PA / FBpp0083234 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Mediator complex subunit 25 is referred to in FlyBase by the symbol Dmel\MED25 (CG12254, FBgn0038760). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:15834718..15837436. It has the cytological map location 92C1. Based on sequence similarity, it is predicted to have molecular function</span>: RNA polymerase II transcription mediator activity. There is experimental evidence that it is involved in the biological process</span>: nervous system development. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 863 amino acids

    Gene Ontology:
    Cellular Component: mediator complex [ISS]
    Biological Process: nervous system development [IMP]
    transcription initiation from RNA polymerase II promoter [ISS]
    Molecular Function: RNA polymerase II transcription mediator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEVDQIPLAD VVFVIEGSAI NGAYINELKT NYILPTLEHF TTGSIDEREY LIAERFATLY  60
   61 GIVVYRTAAN LLEPVCSTYG PFLQPQKVME TIERLPLVGG GMESCAHMAE GFAAAHGCFD 120
  121 DISERRQLLD QTSVQRHCIL ICNSPPYQMP TTESWKYPGK SCEQLAALFN ERKINLSIIA 180
  181 PRKMPVLFKL FMKADGDQPI TSKNYAKNIR HLVLLKGYSL KERAPSPNSM AAQMAAPNAA 240
  241 QATVQQQQQQ QQNQAGQQQQ GQGMPMDTTP AQQQQQQQQQ QQQQQQQGNP QQQVMNMNTM 300
  301 QQQQPGPNPP AGLLNPQQQQ QLLQQQQQNQ FVSNQMQNQN FQQNVGPGQN RWMYPNQPGQ 360
  361 ARPPFMQGAG NVGGVGQGGG MQQNPNSALI SRINAPPPNQ TVTSLQQQQQ QQAQQQQQQQ 420
  421 QQAQQQQQQR MQMLSQQQML NHQQLQQQQQ LAQQQQQQQQ GQQQQQVNPN AGNNMMPASN 480
  481 AGNMSNPQQQ QQQVGQQSNP QQQGNPQQQQ QGNSQQEQAS LREKIWTGVL EWSEKPKSDQ 540
  541 QKIPHTLQCT VCTNIKDGEP EIKAENWPPK LLMQLMPKHL VGNIGGQFLK DSKMVVFRPT 600
  601 PGEALDSLAK MMTSGYAGCV HFSSIPNSPA CDLKVLILLY TPDRNAFLGF IPNNQAMFVE 660
  661 RLRKVIQQKQ HGNMQQQQQQ QQMMQQQGKS PMELQQQQQQ QQQQQQMQQD NSQQQHYNQF 720
  721 QLNMQMGGGG PGGGPGPGPG GMPMQQNQMQ MNMMQQQRMP LGVGVGVGVG PGGVPNPNLQ 780
  781 QQLQQVAPNV AAMQQQQAQQ QQQRMVRPMM SNNNPGLRQL LQHQTTPGNQ FRPQMGGQNP 840
  841 NQMGAGGPMV GNRNFDDGNY EFM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..245] FFAS03 1.02 No description for 2iueA was found.
    2 View Details [246..402] MSA 2.167997 View MSA. No confident structure predictions are available.
    3 View Details [403..564] deduced N/A No confident structure predictions are available.
    4 View Details [565..786] PSI-BLAST 5.0 Sec24
    5 View Details [787..863] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

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