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Protein Overview: KLHL18-PB

General Information:
Name(s) found: KLHL18-PB / FBpp0082030 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\KLHL18 (CG3571, FBgn0037978). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7833832..7836152. It has the cytological map location 87A4-87A5. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: imaginal disc fusion, thorax closure. 4 alleles are reported. The phenotype of these alleles is annotated with: scutellar bristle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 538 amino acids

    Gene Ontology:
    Cellular Component: Cul3-RING ubiquitin ligase complex [IGI][IPI]
    Biological Process: imaginal disc fusion, thorax closure [IMP]
    Molecular Function: protein binding [IEA]
    actin binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPSQLLQVED QTFSAHRVVL AATIPYFYAM FTNNMAESRI KEITMKESAI EPSALESLIN  60
   61 YVYSGQVRID NQNVQNLMVG ASFLQLSNVR DACASFLISR FHPHNVLGIR TFADSMICRQ 120
  121 LIDAADKYID QNFAKVSQSE EFLALDCEQL LELMRRDELN VRTEEVIFEA CMKWVKYAED 180
  181 KRSELFPQVL AAVRLPLLSP QFLADRVARE ELIRSSHQCR DLLDEAKDFH LMPERRGLLQ 240
  241 SFRTRQRSGE FFTGQIYAVG GLASTGESVS TVEIYDPLTK KWKMGEQMSM MRSRVGVAVL 300
  301 NGKLYAFGGF NGTERLSTVE VYDPRKNKWS QGCAMLCKRS AVGVAALDDC IYVCGGYDGV 360
  361 TSLNTVEVYY PKSNTWKTVA QMMKYRSAGG VTQLNGYVYA LGGHDGLSIF DSVERYDQAE 420
  421 DVWVKMSPML NRRCRLGVAT LNGKIYVCGG YCGNSFLRSV ECYDPQTDTW KLVTPMNCKR 480
  481 SRVALAANMG KLWAIGGYDG ESNLSTVEVY DPETDKWTFM PPMCAHSGGV GAGVIRIE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..104] PSI-BLAST 22.0 No description for 2if5A was found.
    2 View Details [105..235] FFAS03 4.8 No description for 2eqxA was found.
    3 View Details [236..538] PSI-BLAST 82.30103 Crystal structure of the Kelch domain of human Keap1


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.79

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle