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Protein Overview: KLHL18-PA, FBpp0...

General Information:
Name(s) found: FBpp0307415 [FlyBase]
KLHL18-PA / FBpp0082029 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • type=protein; loc=3R:complement(7834135..7834617,7834691..7834949,7835012..7835865,7835964..7836095); ID=FBpp0307415; name=KLHL18-PC; parent=FBgn0037978,FBtr0335434; dbxref=REFSEQ:NP_001262494,GB_protein:AGB95876,FlyBase:FBpp0307415,FlyBase_Annotation_IDs:CG3571-PC; MD5=9b8241223755ad663bd413b7d93b8b56; length=575; release=r5.56; species=Dmel; [FlyBase]
  • This gene is referred to in FlyBase by the symbol Dmel\KLHL18 (CG3571, FBgn0037978). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7833832..7836152. It has the cytological map location 87A4-87A5. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: imaginal disc fusion, thorax closure. 4 alleles are reported. The phenotype of these alleles is annotated with: scutellar bristle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 575 amino acids

    Gene Ontology:
    Cellular Component: Cul3-RING ubiquitin ligase complex [IGI][IPI]
    Biological Process: imaginal disc fusion, thorax closure [IMP]
    Molecular Function: protein binding [IEA]
    actin binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLSDNSQVE DQYFVYKHDK LFGESFPLFK EIRRMGKLCD VTLKVEDQTF SAHRVVLAAT  60
   61 IPYFYAMFTN NMAESRIKEI TMKESAIEPS ALESLINYVY SGQVRIDNQN VQNLMVGASF 120
  121 LQLSNVRDAC ASFLISRFHP HNVLGIRTFA DSMICRQLID AADKYIDQNF AKVSQSEEFL 180
  181 ALDCEQLLEL MRRDELNVRT EEVIFEACMK WVKYAEDKRS ELFPQVLAAV RLPLLSPQFL 240
  241 ADRVAREELI RSSHQCRDLL DEAKDFHLMP ERRGLLQSFR TRQRSGEFFT GQIYAVGGLA 300
  301 STGESVSTVE IYDPLTKKWK MGEQMSMMRS RVGVAVLNGK LYAFGGFNGT ERLSTVEVYD 360
  361 PRKNKWSQGC AMLCKRSAVG VAALDDCIYV CGGYDGVTSL NTVEVYYPKS NTWKTVAQMM 420
  421 KYRSAGGVTQ LNGYVYALGG HDGLSIFDSV ERYDQAEDVW VKMSPMLNRR CRLGVATLNG 480
  481 KIYVCGGYCG NSFLRSVECY DPQTDTWKLV TPMNCKRSRV ALAANMGKLW AIGGYDGESN 540
  541 LSTVEVYDPE TDKWTFMPPM CAHSGGVGAG VIRIE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..138] PSI-BLAST 25.69897 No description for 2nn2A was found.
    2 View Details [139..272] FFAS03 4.26 No description for 2eqxA was found.
    3 View Details [273..575] PSI-BLAST 82.522879 1.35 angstrom structure of the Kelch domain of Keap1


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle