Protein Overview: Mical-PG, Mical-...

General Information:
Name(s) found:	Mical-PD / FBpp0081691 [FlyBase] Mical-PG / FBpp0081690 [FlyBase] Mical-PH / FBpp0081689 [FlyBase] Mical-PC / FBpp0081688 [FlyBase] Mical-PF / FBpp0081687 [FlyBase]
Description(s) found: Found 63 descriptions. SHOW ALL	The gene Molecule interacting with CasL is referred to in FlyBase by the symbol Dmel\Mical (CG33208, FBgn0053208). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5828033..5868543. It has the cytological map location 85F5-85F7. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; sarcomere organization. 24 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; nervous system; multi-cell-component structure; anatomical structure; peripheral nervous system; embryonic nervous system; cytoplasmic part; contractile fiber; cell component; abdominal segmental nerve; protein complex; adult segment. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase] The gene Molecule interacting with CasL is referred to in FlyBase by the symbol Dmel\Mical (CG33208, FBgn0053208). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5828033..5868543. It has the cytological map location 85F5-85F7. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; sarcomere organization. 24 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; nervous system; multi-cell-component structure; anatomical structure; peripheral nervous system; embryonic nervous system; cytoplasmic part; contractile fiber; cell component; abdominal segmental nerve; protein complex; adult segment. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase] The gene Molecule interacting with CasL is referred to in FlyBase by the symbol Dmel\Mical (CG33208, FBgn0053208). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5828033..5868543. It has the cytological map location 85F5-85F7. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; sarcomere organization. 24 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; nervous system; multi-cell-component structure; anatomical structure; peripheral nervous system; embryonic nervous system; cytoplasmic part; contractile fiber; cell component; abdominal segmental nerve; protein complex; adult segment. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase] The gene Molecule interacting with CasL is referred to in FlyBase by the symbol Dmel\Mical (CG33208, FBgn0053208). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5828033..5868543. It has the cytological map location 85F5-85F7. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; sarcomere organization. 24 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; nervous system; multi-cell-component structure; anatomical structure; peripheral nervous system; embryonic nervous system; cytoplasmic part; contractile fiber; cell component; abdominal segmental nerve; protein complex; adult segment. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase] The gene Molecule interacting with CasL is referred to in FlyBase by the symbol Dmel\Mical (CG33208, FBgn0053208). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5828033..5868543. It has the cytological map location 85F5-85F7. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; sarcomere organization. 24 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; nervous system; multi-cell-component structure; anatomical structure; peripheral nervous system; embryonic nervous system; cytoplasmic part; contractile fiber; cell component; abdominal segmental nerve; protein complex; adult segment. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	4723 amino acids
Gene Ontology:
Cellular Component:	terminal button [IDA] cytosol [NAS] plasma membrane [IDA]
Biological Process:	sarcomere organization [IMP] axon guidance [IMP][TAS] neuron remodeling [IGI][IMP] dendrite morphogenesis [IGI][IMP]
Molecular Function:	zinc ion binding [IEA] actin binding [ISS] oxidoreductase activity [IEA] electron carrier activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
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    1 MSRQHQRHHQ QHHHLPPHQQ PQQQMPQQQQ QLTAQQQQQQ QLLMAEHAAA AEAAELFDLL  60
   61 CVATTMRQIL ALHRAMCEAV GLRPSPLNDF YPRLKAKVRS WKAQALWKKF DARAAHRVYG 120
  121 KGAACTGTRV LVIGAGPCGL RTAIEAQLLG AKVVVLEKRD RITRNNVLHL WPFVITDLRN 180
  181 LGAKKFYGKF CAGSIDHISI RQLQCMLLKV ALLLGVEIHE GVSFDHAVEP SGDGGGWRAA 240
  241 VTPADHPVSH YEFDVLIGAD GKRNMLDFRR KEFRGKLAIA ITANFINKKT EAEAKVEEIS 300
  301 GVAFIFNQAF FKELYGKTGI DLENIVYYKD ETHYFVMTAK KHSLIDKGVI IEDMADPGEL 360
  361 LAPANVDTQK LHDYAREAAE FSTQYQMPNL EFAVNHYGKP DVAMFDFTSM FAAEMSCRVI 420
  421 VRKGARLMQC LVGDSLLEPF WPTGSGCARG FLSSMDAAYA IKLWSNPQNS TLGVLAQRES 480
  481 IYRLLNQTTP DTLQRDISAY TVDPATRYPN LNRESVNSWQ VKHLVDTDDP SILEQTFMDT 540
  541 HALQTPHLDT PGRRKRRSGD LLPQGATLLR WISAQLHSYQ FIPELKEASD VFRNGRVLCA 600
  601 LINRYRPDLI DYAATKDMSP VECNELSFAV LERELHIDRV MSAKQSLDLT ELESRIWLNY 660
  661 LDQICDLFRG EIPHIKHPKM DFSDLRQKYR INHTHAQPDF SKLLATKPKA KSPMQDAVDI 720
  721 PTTVQRRSVL EEERAKRQRR HEQLLNIGGG AAGAAAGVAG SGTGTTTQGQ NDTPRRSKKR 780
  781 RQVDKTANIE ERQQRLQEIE ENRQERMSKR RQQRYHQTQN FYKSLQLLQA GKLLREGGEA 840
  841 GVAEDGTPFE DYSIFLYRQQ APVFNDRVKD LERKLLFPDR ERGDIPSALP RTADEQFSDR 900
  901 IKNMEQRMTG RGGLGGDKKP KDLMRAIGKI DSNDWNVREI EKKIELSKKT EIHGPKGREK 960
  961 VPKWSKEQFQ ARQHKMSKPQ RQDSREAEKF KDIDQTIRNL DKQLKEGHNL DVGERGRNKV1020
 1021 ASIAGQFGKK DEANSDEKNA GSSNATTNTN NTVIPKSSSK VALAFKKQAA SEKCRFCKQT1080
 1081 VYLMEKTTVE GLVLHRNCLK CHHCHTNLRL GGYAFDRDDP QGRFYCTQHF RLPPKPLPQR1140
 1141 TNKARKSAAA QPASPAVPPT AGSVPTAAAT SEHMDTTPPR DQVDLLETSR ANASADAMSD1200
 1201 DEANVIDEHE WSGRNFLPES NNDSQSELSS SDESDTESDS EMFEEADDSP FGAQTLQLAS1260
 1261 DWIGKQYCED SDDSDDFYDS SEGIADDGKD DTEGEEFKKA RELRRQEVRL QPLPANLPTD1320
 1321 TETEKLKLNV DNKENMADRS SLKSGNSFES ARSQPSTPLS TPTRVEMEQL ERNAPRKFSS1380
 1381 EIEAISEKLY HMNNMVKMNK DLEVLAKENL VKSDILRKLT LKEKWLAENA AIAAGQKVTP1440
 1441 TPSATAPGLQ PKSKFDEKFE KVVSPPQPVV EPKPKPVIDF NLDELKPRKP NFEERPKEQL1500
 1501 PRPESLKKPP QQKPKGSSTN VSRSNSLKSN ASNGSPKVKK APISNNSKMQ IEGILGTLRK1560
 1561 IQSQNSSDQD EDMDVDEDVE RKPNKELNSK LKEIQASSFA GTMDHIKSQL TMPTVSAQAP1620
 1621 PSMDLSKYFP NQKQEKSSTS STNKNQVTLK DVNLAKYFPS SPAPQRRTVE TVADRLKKSQ1680
 1681 TEAALAKTKL LEDQANNQAE KTKKEVEKEG ESKKITKKVA DSKAVPPKRQ ASLDTFSLRE1740
 1741 HQMDGALDLT KKKGPTKASA GVKKPAKSGS TTSVTKATAT SKGKTIKIVK KIVPKGTKAK1800
 1801 KAAEAAQESA VVEAPPEKKP PKDEAERILD EILGDGEYRS PSSEYQRLFQ DEKSPSDLSD1860
 1861 NIDRILEESG LDVELGLPKR SSKKLVKTKS LGEGDFDMKP SKERLTGVQN ILKRFESMSS1920
 1921 VTSQNSDEQA AFKLRRMEST TSNLSSLTRS RESLVSVSDS MSDLEKTMDY LRNEWRNEAT1980
 1981 NFLQKKRDKF YAKKEEQEKE SKILAKPDPL DNLPVQYRDS KLAKFFGLAA SKSPENRKSP2040
 2041 IKKKKSPSKT PKVTKANNSL EELAKISNVR QTKKAQPKTL KPVEVKPLKP ASPVPDDFEI2100
 2101 LDLLEKATEA KELERSKTKS PAVESISQTP KEAIVEISLP VEDIKNLPKT GCDKSSNSSR2160
 2161 RGSQSSLIMS RRHSEISLNE KLNQDALAAL NQIEKEREAE QVDELFQSMV EEMEQEPQPT2220
 2221 AIVEPPEEDI DADSLCTTIS KSPSAQPVTV VKRGSSEDQS IEKLFSHFSD EMLVNVEFDS2280
 2281 NDELVGITPR ATLVSRNTED RDYLDKLESL ERDEETFQPV VGEKFIQENV QDEVDGLHFP2340
 2341 SRPQRRPKSS SSSSEPSLPV APQRLKKKLS KLDPEDMPPS VQDLLQQVYQ KNIQPELVEV2400
 2401 IPVEGKQTLR FPSMLAEEDV DEVDHSKEGI KKIETAPEEV RKVTEPEDVA RVIPSPIKPS2460
 2461 ISQSNSLKSE NSSGSSLVEI PKIITPPKSS SKENSSDWDM EKLPASPMPR RRLLPNQTPY2520
 2521 KAPSVASKES SLEWDMEKLP NSPMLPRRNK MRAISPSTNP VQLLNNLPSD VDDEAAQRRL2580
 2581 IEDFEQERRQ ALIKRDENFE AIAAEQRRRD SLQSSSNSSS KRSLPPPTPP MMASRRGTTQ2640
 2641 DTNRTQDTAS RHEGTPPMFK KLDVDGSGTS MDSTSCSTRR SSFAFIELQD NKPVIVPMPK2700
 2701 KLKLPKPEPP RFVPEPVATD EPVPEVFQGR AWPKTQLEGE VDLGDSDNED ETEKLKKQLP2760
 2761 EYARSDSPPS AAFKNRKWPD GKTVFDKRAE SLEEEDIFEG LLSPRKRGSQ RFMDKPRSQS2820
 2821 PQPFKPLANS SRKSSKSFSD LKKGPSLQSL SAQSSQDTDT LSTTTTVATA RPASYANYED2880
 2881 PMDASTQALL DRSKRLHNRK RDFVNERVVE RNPYMRDVLR STDRRDYDDV DEDLTSYRPR2940
 2941 HYASSTLNRF PNTTIRKSNN YDYLSPSSDY LSRRSYIPSA SATSSYYPST TRSSHLSDLF3000
 3001 RRRSPASGTV SALSGYGNKE SCIGLALDRV GHLIESKCTW VRSTKVQTES ESTSPDEVEL3060
 3061 NSATEISTDS EFDNDEIIRQ APKIFIDDTH LRKPTKVQIK STMIGPNAAS AGLHQKQLAA3120
 3121 REKGGSYLQK YQPQPPLPQF KPLVQVDPTL LIGSQRAPLQ NPRPGDYLLN KTASTEGIAS3180
 3181 KKSLELKKRY LLGEPANGNK IQKSGSTSVL DSRIRSFQSN ISECQKLLNP SSDISAGMRT3240
 3241 FLDRTKLGEG SQTTPGQTNE LIRSATSNVI NDLRVELRIQ KTGSSHSTDN EKENVFVNCK3300
 3301 NELNKGMEYT DAVNATLLDQ LARKSSPTTP TNKTVVEVID LVTPEKPIDI IDLTALETPK3360
 3361 KQLVDGSAMD VDERLTPDSN KISELQQEVK EEPKPDVSRD VKECIPDILG HIKEGTGSKE3420
 3421 PGGEDQQSLL EQSDEEKRDS PEKDVAEHEL YEPDSVQIQV PNIPWEKSKP EVMSTTGSSG3480
 3481 SICSSSDSSS IEDIQHYILE STTSPDTQTV GGKHNVPRLE VHDTSGALMQ VDSLMIVNGK3540
 3541 YIGDPEDVKF LDMPANVIVP PAPALKTNEL DMEDDQEAEA EPVTATPEPV ECTVIEAERR3600
 3601 VTAPPPLPEM GPPKLKFDSK NENKIESLKN LPLIVESNVE HSQAVKPITL NLSNLARTPD3660
 3661 TPTTPTAHDS DKTPTGEILS RGSDSETEHT GTGQVLTETE LSDWTADDCI SENFVDLEFA3720
 3721 LNSNKGTIKR RKDRRRSGAS KLPSGNEVIH ELARQAPVVQ MDGILSAIDI DDIEFMDTGS3780
 3781 EGSCAEAYSA TNTALIQNRG YMEYIEAEPK KTTRKAAPPS SYPGNLPPLM TKRDEKLGVD3840
 3841 YIEQGAYIMH DDAKTPVNEV APAMTQSLTD SITLNELDDD SMIISQTQPT TTEESEALTV3900
 3901 VTSPLDTSSP RVLDQFASML AAGKGDSTPS SSEQQPKTST VTSSSTGPNS STTGNVSKEP3960
 3961 QEEDLQIQFE YVRALQQRIS QISTQRRKSS KGEAPNLQLN SSAPVIESAE DPAKPAEEPL4020
 4021 VSMRPRTTSI SGKVPEIPTL SSKLEEITKE RTKQKDLIHD LVMDKLQSKK QLNAEKRLHR4080
 4081 SRQRSLLTSG YASGSSLSPT PKLAAACSPQ DSNCSSQAHY HASTAEEAPK PPAERPLQKS4140
 4141 ATSTYVSPYR TVQAPTRSAD LYKPRPFSEH IDSNALAGYK LGKTASFNGG KLGDFAKPIA4200
 4201 PARVNRGGGV ATADIANISA STENLRSEAR ARARLKSNTE LGLSPEEKMQ LIRSRLHYDQ4260
 4261 NRSLKPKQLE EMPSGDLAAR ARKMSASKSV NDLAYMVGQQ QQQQVEKDAV LQAKAADFTS4320
 4321 DPNLASGGQE KAGKTKSGRR PKDPERRKSL IQSLSSFFQK GSGSAASSSK EQGGAVAAVH4380
 4381 SEQSERPGTS SSGTPTISDA AGGGGGGGGV FSRFRISPKS KEKSKSCFDL RNFGFGDKDM4440
 4441 LVCNAASPAG ATSASQKNHS QEYLNTTNNS RYRKQTNTAK PKPESFSSSS PQLYIHKPHH4500
 4501 LAAAHPSALD DQTPPPIPPL PLNYQRSDDE SYANETREHK KQRAISKASR QAELKRLRIA4560
 4561 QEIQREQEEI EVQLKDLEAR GVLIEKALRG EAQNIENLDA TKDNDEKLLK ELLEIWRNIT4620
 4621 ALKKRDEELT IRQQELQLEY RHAQLKEELN LRLSCNKLDK SSADVAAEGA ILNEMLEIVA4680
 4681 KRAALRPTAS QLDLTAAGSA STSAEATGIK LTGQPHDHEE SII

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.91

Protein Overview: Mical-PG, Mical-...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: