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Protein Overview: Mical-PE

General Information:
Name(s) found: Mical-PE / FBpp0081686 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Molecule interacting with CasL is referred to in FlyBase by the symbol Dmel\Mical (CG33208, FBgn0053208). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5828033..5868543. It has the cytological map location 85F5-85F7. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; sarcomere organization. 24 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; nervous system; multi-cell-component structure; anatomical structure; peripheral nervous system; embryonic nervous system; cytoplasmic part; contractile fiber; cell component; abdominal segmental nerve; protein complex; adult segment. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2734 amino acids

    Gene Ontology:
    Cellular Component: terminal button [IDA]
    cytosol [NAS]
    plasma membrane [IDA]
    Biological Process: sarcomere organization [IMP]
    axon guidance [IMP][TAS]
    neuron remodeling [IGI][IMP]
    dendrite morphogenesis [IGI][IMP]
    Molecular Function: zinc ion binding [IEA]
    actin binding [ISS]
    oxidoreductase activity [IEA]
    electron carrier activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRQHQRHHQ QHHHLPPHQQ PQQQMPQQQQ QLTAQQQQQQ QLLMAEHAAA AEAAELFDLL  60
   61 CVATTMRQIL ALHRAMCEAV GLRPSPLNDF YPRLKAKVRS WKAQALWKKF DARAAHRVYG 120
  121 KGAACTGTRV LVIGAGPCGL RTAIEAQLLG AKVVVLEKRD RITRNNVLHL WPFVITDLRN 180
  181 LGAKKFYGKF CAGSIDHISI RQLQCMLLKV ALLLGVEIHE GVSFDHAVEP SGDGGGWRAA 240
  241 VTPADHPVSH YEFDVLIGAD GKRNMLDFRR KEFRGKLAIA ITANFINKKT EAEAKVEEIS 300
  301 GVAFIFNQAF FKELYGKTGI DLENIVYYKD ETHYFVMTAK KHSLIDKGVI IEDMADPGEL 360
  361 LAPANVDTQK LHDYAREAAE FSTQYQMPNL EFAVNHYGKP DVAMFDFTSM FAAEMSCRVI 420
  421 VRKGARLMQC LVGDSLLEPF WPTGSGCARG FLSSMDAAYA IKLWSNPQNS TLGVLAQRES 480
  481 IYRLLNQTTP DTLQRDISAY TVDPATRYPN LNRESVNSWQ VKHLVDTDDP SILEQTFMDT 540
  541 HALQTPHLDT PGRRKRRSGD LLPQGATLLR WISAQLHSYQ FIPELKEASD VFRNGRVLCA 600
  601 LINRYRPDLI DYAATKDMSP VECNELSFAV LERELHIDRV MSAKQSLDLT ELESRIWLNY 660
  661 LDQICDLFRG EIPHIKHPKM DFSDLRQKYR INHTHAQPDF SKLLATKPKA KSPMQDAVDI 720
  721 PTTVQRRSVL EEERAKRQRR HEQLLNIGGG AAGAAAGVAG SGTGTTTQGQ NDTPRRSKKR 780
  781 RQVDKTANIS SKVALAFKKQ AASEKCRFCK QTVYLMEKTT VEGLVLHRNC LKCHHCHTNL 840
  841 RLGGYAFDRD DPQGRFYCTQ HFRLPPKPLP QRTNKARKSA AAQPASPAVP PTAGSVPTAA 900
  901 ATSEHMDTTP PRDQVDLLET SRANASADAM SDDEANVIDE HEWSGRNFLP ESNNDSQSEL 960
  961 SSSDESDTES DSEMFEEADD SPFGAQTLQL ASDWIGKQYC EDSDDSDDFY DSSEGIADDG1020
 1021 KDDTEGEEFK KARELRRQEV RLQPLPANLP TDTETEVQTE SESTSPDEVE LNSATEISTD1080
 1081 SEFDNDEIIR QAPKIFIDDT HLRKPTKVQI KSTMIGPNAA SAGLHQKQLA AREKGGSYLQ1140
 1141 KYQPQPPLPQ FKPLVQVDPT LLIGSQRAPL QNPRPGDYLL NKTASTEGIA SKKSLELKKR1200
 1201 YLLGEPANGN KIQKSGSTSV LDSRIRSFQS NISECQKLLN PSSDISAGMR TFLDRTKLGE1260
 1261 GSQTTPGQTN ELIRSATSNV INDLRVELRI QKTGSSHSTD NEKENVFVNC KNELNKGMEY1320
 1321 TDAVNATLLD QLARKSSPTT PTNKTVVEVI DLVTPEKPID IIDLTALETP KKQLVDGSAM1380
 1381 DVDERLTPDS NKISELQQEV KEEPKPDVSR DVKECIPDIL GHIKEGTGSK EPGGEDQQSL1440
 1441 LEQSDEEKRD SPEKDVAEHE LYEPDSVQIQ VPNIPWEKSK PEVMSTTGSS GSICSSSDSS1500
 1501 SIEDIQHYIL ESTTSPDTQT VGGKHNVPRL EVHDTSGALM QVDSLMIVNG KYIGDPEDVK1560
 1561 FLDMPANVIV PPAPALKTNE LDMEDDQEAE AEPVTATPEP VECTVIEAER RVTAPPPLPE1620
 1621 MGPPKLKFDS KNENKIESLK NLPLIVESNV EHSQAVKPIT LNLSNLARTP DTPTTPTAHD1680
 1681 SDKTPTGEIL SRGSDSETEH TGTGQVLTET ELSDWTADDC ISENFVDLEF ALNSNKGTIK1740
 1741 RRKDRRRSGA SKLPSGNEVI HELARQAPVV QMDGILSAID IDDIEFMDTG SEGSCAEAYS1800
 1801 ATNTALIQNR GYMEYIEAEP KKTTRKAAPP SSYPGNLPPL MTKRDEKLGV DYIEQGAYIM1860
 1861 HDDAKTPVNE VAPAMTQSLT DSITLNELDD DSMIISQTQP TTTEESEALT VVTSPLDTSS1920
 1921 PRVLDQFASM LAAGKGDSTP SSSEQQPKTS TVTSSSTGPN SSTTGNVSKE PQEEDLQIQF1980
 1981 EYVRALQQRI SQISTQRRKS SKGEAPNLQL NSSAPVIESA EDPAKPAEEP LVSMRPRTTS2040
 2041 ISGKVPEIPT LSSKLEEITK ERTKQKDLIH DLVMDKLQSK KQLNAEKRLH RSRQRSLLTS2100
 2101 GYASGSSLSP TPKLAAACSP QDSNCSSQAH YHASTAEEAP KPPAERPLQK SATSTYVSPY2160
 2161 RTVQAPTRSA DLYKPRPFSE HIDSNALAGY KLGKTASFNG GKLGDFAKPI APARVNRGGG2220
 2221 VATADIANIS ASTENLRSEA RARARLKSNT ELGLSPEEKM QLIRSRLHYD QNRSLKPKQL2280
 2281 EEMPSGDLAA RARKMSASKS VNDLAYMVGQ QQQQQVEKDA VLQAKAADFT SDPNLASGGQ2340
 2341 EKAGKTKSGR RPKDPERRKS LIQSLSSFFQ KGSGSAASSS KEQGGAVAAV HSEQSERPGT2400
 2401 SSSGTPTISD AAGGGGGGGG VFSRFRISPK SKEKSKSCFD LRNFGFGDKD MLVCNAASPA2460
 2461 GATSASQKNH SQEYLNTTNN SRYRKQTNTA KPKPESFSSS SPQLYIHKPH HLAAAHPSAL2520
 2521 DDQTPPPIPP LPLNYQRSDD ESYANETREH KKQRAISKAS RQAELKRLRI AQEIQREQEE2580
 2581 IEVQLKDLEA RGVLIEKALR GEAQNIENLD ATKDNDEKLL KELLEIWRNI TALKKRDEEL2640
 2641 TIRQQELQLE YRHAQLKEEL NLRLSCNKLD KSSADVAAEG AILNEMLEIV AKRAALRPTA2700
 2701 SQLDLTAAGS ASTSAEATGI KLTGQPHDHE ESII

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
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