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Protein Overview: Mical-PA

General Information:
Name(s) found: Mical-PA / FBpp0081684 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Molecule interacting with CasL is referred to in FlyBase by the symbol Dmel\Mical (CG33208, FBgn0053208). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:5828033..5868543. It has the cytological map location 85F5-85F7. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; sarcomere organization. 24 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; nervous system; multi-cell-component structure; anatomical structure; peripheral nervous system; embryonic nervous system; cytoplasmic part; contractile fiber; cell component; abdominal segmental nerve; protein complex; adult segment. It has 9 annotated transcripts and 9 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 810 amino acids

    Gene Ontology:
    Cellular Component: terminal button [IDA]
    cytosol [NAS]
    plasma membrane [IDA]
    Biological Process: sarcomere organization [IMP]
    axon guidance [IMP][TAS]
    neuron remodeling [IGI][IMP]
    dendrite morphogenesis [IGI][IMP]
    Molecular Function: zinc ion binding [IEA]
    actin binding [ISS]
    oxidoreductase activity [IEA]
    electron carrier activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRQHQRHHQ QHHHLPPHQQ PQQQMPQQQQ QLTAQQQQQQ QLLMAEHAAA AEAAELFDLL  60
   61 CVATTMRQIL ALHRAMCEAV GLRPSPLNDF YPRLKAKVRS WKAQALWKKF DARAAHRVYG 120
  121 KGAACTGTRV LVIGAGPCGL RTAIEAQLLG AKVVVLEKRD RITRNNVLHL WPFVITDLRN 180
  181 LGAKKFYGKF CAGSIDHISI RQLQCMLLKV ALLLGVEIHE GVSFDHAVEP SGDGGGWRAA 240
  241 VTPADHPVSH YEFDVLIGAD GKRNMLDFRR KEFRGKLAIA ITANFINKKT EAEAKVEEIS 300
  301 GVAFIFNQAF FKELYGKTGI DLENIVYYKD ETHYFVMTAK KHSLIDKGVI IEDMADPGEL 360
  361 LAPANVDTQK LHDYAREAAE FSTQYQMPNL EFAVNHYGKP DVAMFDFTSM FAAEMSCRVI 420
  421 VRKGARLMQC LVGDSLLEPF WPTGSGCARG FLSSMDAAYA IKLWSNPQNS TLGVLAQRES 480
  481 IYRLLNQTTP DTLQRDISAY TVDPATRYPN LNRESVNSWQ VKHLVDTDDP SILEQTFMDT 540
  541 HALQTPHLDT PGRRKRRSGD LLPQGATLLR WISAQLHSYQ FIPELKEASD VFRNGRVLCA 600
  601 LINRYRPDLI DYAATKDMSP VECNELSFAV LERELHIDRV MSAKQSLDLT ELESRIWLNY 660
  661 LDQICDLFRG EIPHIKHPKM DFSDLRQKYR INHTHAQPDF SKLLATKPKA KSPMQDAVDI 720
  721 PTTVQRRSVL EEERAKRQRR HEQLLNIGGG AAGAAAGVAG SGTGTTTQGQ NDTPRRSKKR 780
  781 RQVDKTANIV SKCWHYFISW IGSYANVQKV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..526] PSI-BLAST 151.0 Crystal structure of the native monooxygenase domain of MICAL at 1.45 A resolution
    2 View Details [527..810] PSI-BLAST 101.0 Cryo-EM Structure of Chicken Gizzard Smooth Muscle alpha-Actinin


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.63

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle