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Protein Overview: kkv-PA, kkv-PC

General Information:
Name(s) found: kkv-PC / FBpp0089164 [FlyBase]
kkv-PA / FBpp0078442 [FlyBase]
Description(s) found:
Found 31 descriptions.
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  • The gene krotzkopf verkehrt is referred to in FlyBase by the symbol Dmel\kkv (CG2666, FBgn0001311). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1203815..1218587. It has the cytological map location 83A1. Based on sequence similarity, it is predicted to have molecular function</span>: chitin synthase activity. There is experimental evidence that it is involved in the biological process</span>: Malpighian tubule morphogenesis; regulation of tube diameter, open tracheal system; embryonic epithelial tube formation; open tracheal system development; regulation of tube length, open tracheal system; chitin-based embryonic cuticle biosynthetic process; cuticle chitin biosynthetic process. 31 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system; cuticle; cephalopharyngeal skeleton; integumentary system; embryonic/larval tracheal system; portion of tissue; pharyngeal sclerite; Malpighian tubule; tracheal system; cuticular specialization. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene krotzkopf verkehrt is referred to in FlyBase by the symbol Dmel\kkv (CG2666, FBgn0001311). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1203815..1218587. It has the cytological map location 83A1. Based on sequence similarity, it is predicted to have molecular function</span>: chitin synthase activity. There is experimental evidence that it is involved in the biological process</span>: Malpighian tubule morphogenesis; regulation of tube diameter, open tracheal system; embryonic epithelial tube formation; open tracheal system development; regulation of tube length, open tracheal system; chitin-based embryonic cuticle biosynthetic process; cuticle chitin biosynthetic process. 31 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system; cuticle; cephalopharyngeal skeleton; integumentary system; embryonic/larval tracheal system; portion of tissue; pharyngeal sclerite; Malpighian tubule; tracheal system; cuticular specialization. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1615 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [ISS]
    Biological Process: chitin-based embryonic cuticle biosynthetic process [IMP]
    Malpighian tubule morphogenesis [IMP]
    cuticle chitin biosynthetic process [IMP]
    embryonic epithelial tube formation [IMP]
    regulation of tube diameter, open tracheal system [IMP]
    regulation of tube length, open tracheal system [IMP]
    open tracheal system development [IMP]
    Molecular Function: chitin synthase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAMRHRPMA PPGQGPGAGT AGEHVDSDDN NFTDDESSPL THDIYGGSQR TIQETKGWDV  60
   61 FRDPPIKIET GSTANQECLE LTVKILKIFA YVITFIIVLT GGVIAKGTML FMTSQVRKDK 120
  121 KMEYCNKDLG RDKSFVVRLP EEERVAWIWA LLIAYALPEI GALIRSARIC FFKTFKVPKT 180
  181 GHFLFVWLME SLSAVGMALL MFVVLPQIDA IQGAMLTNCL CVVPGIFGLL SRTSKEGKRF 240
  241 VKVIIDLAAV AAQVTGLVIW PLLENRRELW VIPVACVMIS CGWWENYVSP QSPLGLVRAL 300
  301 GRIKEEMKYT RYFCHIFLSI WKILLFFTVT LLIYWAQGEE PGNLFAMYGD AFGPHKIIVY 360
  361 ELPAGLGGVL PDTLESANID TVDVDAAYNT VVYVLLLQIF GAYLCYIFGK FACKILIQGF 420
  421 SYAFPVSLTV PLSVTFLIAA CGIRIDDPCF FHDTIPDYLF FTSPSNFRFN NFVTEQMAWA 480
  481 WILWLLSQTW IALHIWTPKC ERLATTEKLF VQPMYSSLLI DQSMALNRRR DDQADVKTED 540
  541 LSEIEKEKGD EYYETISVHT DRSSAPNKPS IKSSDNITRI YSCATMWHET KDEMIEFLKS 600
  601 IMRMDEDQCA RRVAQKYLRV LDPDYYEFET HIFFDDAFEI SDHSDDDIQC NRFVKLLIAT 660
  661 MDEAASEIHQ TTIRLRPPKK YPTPYGGRLV WTLPGKTKFI THLKDKDRIR HRKRWSQVMY 720
  721 MYYLLGHRLM ELPISVDRKD AIAENTYLLT LDGDIDFKPN AVTLLVDLMK KNKNLGAACG 780
  781 RIHPVGSGPM VWYQLFEYAI GHWLQKATEH MIGCVLCSPG CFSLFRGKAL MDDNVMKKYT 840
  841 TRSDEARHYV QYDQGEDRWL CTLLLQRGYR VEYSAASDAY THCPEGFNEF YNQRRRWVPS 900
  901 TIANIMDLLA DAKRTIKIND NISLLYIFYQ MMLMGGTILG PGTIFLMLVG AFVAAFRIDN 960
  961 WTSFHYNIVP ILAFMFICFT CKSNIQLFVA QVLSTAYALI MMAVIVGTAL QLGEDGIGSP1020
 1021 SAIFLISMVG SFFIAACLHP QEFWCITCGL IYLLSIPSMY LLLILYSIIN LNVVSWGTRE1080
 1081 VVAKKTKKEL EAEKKAAEEA KKRVKQKSML SFLQSGIGDN GDEEGSVEFS LAGLFRCIFC1140
 1141 THGKTSDEKQ QLTSIAESLD TIKHRMDTIE SAVDPHGHHA SRHGRRRTTS SGSKDHHLLT1200
 1201 SVAEKSGDES DESDSDTSAE PKQERDFLTN PYWIEDPDVR KGEVDFLSST EIQFWKDLID1260
 1261 QYLYPIDNDP VEQARIAKDL KELRDSSVFA FFMINALFVL IVFLLQLNKD NIHVKWPFGV1320
 1321 RTNITYDEST QEVHISKEYL QLEPIGLVFV FFFALILIIQ FTAMLFHRFG TISHILASTE1380
 1381 LNFCKKKSED LTQDQLIDKH AVEIVKNLQR LQGIDGDYDN DSGSGPDRIA RRKTIQNLEK1440
 1441 ARQPRRQIGT LDVAFKKRFL KLTADAENNP ATPILTRRLT MRAETIRALE VRKNSVMAER1500
 1501 RKSAMQTLGA KNEYGITTGA PINNNGALPN QRSGRVSNAG ISIKDVFNVN GGGAEQIYGS1560
 1561 NGGGTINQGY EHVIDEDGDG NSLRLTTRNP HPHPHHQVSW GQNTNGGGGN GTGRL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..175] deduced N/A No confident structure predictions are available.
    2 View Details [176..365] MSA 1.024953 View MSA. No confident structure predictions are available.
    3 View Details [366..629] deduced N/A No confident structure predictions are available.
    4 View Details [630..897] PSI-BLAST 9.221849 Crystal Structure of Human ppGalNAcT-2 complexed with UDP and EA2
    5 View Details [898..1015] MSA 2.372996 View MSA. No confident structure predictions are available.
    6 View Details [1016..1234] deduced N/A No confident structure predictions are available.
    7 View Details [1235..1385] MSA 1.026951 View MSA. No confident structure predictions are available.
    8 View Details [1386..1615] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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