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Protein Overview: CG14650-PA

General Information:
Name(s) found: CG14650-PA / FBpp0078566 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG14650 (CG14650, FBgn0037252). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:263102..267050. It has the cytological map location 82B1. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: heat shock protein binding; unfolded protein binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: response to heat. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 970 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: response to heat [ISS]
    protein folding [IEA]
    Molecular Function: heat shock protein binding [IEA]
    unfolded protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATRQDDEIG GGSTESAPFR VLPHTDEVGN YLAHQQQQQQ QQQHQHQTQN YLIHQQQHGQ  60
   61 APVPLMWPPP PPHLAGPPFA PHLQQQQPHM YNEYLFNLSY SGQPGQPETY SVLPVGPGNF 120
  121 LKVYHCPDNQ VSEAGTPLFT HINMASINHH QLQHQHQAAP PTPSQPTPLY ELFATNPLTL 180
  181 PHAQQQDAQH RQPQQTQTQA PTVSQVNHSS SSANLLINNL VNNWSPNLTG GSYIQFDGEA 240
  241 NEMDVVLETS IAQQPQVPNQ NLQQPEPLSQ SVNTLPAASK PAKSLKMPLA TATVSPTAIN 300
  301 KSSVAVPGQP EGKKRIVAEV KPMPMSYSDV LSKGTKPSAA GRDMRADNGG DYSVQSQRRP 360
  361 EKEDAYGNRE MRTSKRSPLH DAKETGSFVP GVGHAHASRG KKRSKVSQTA PLKVQQSQSL 420
  421 AQPNLQPQIK SNKLNNPEKK RPLQPKNVNS NAPKFSEHKT TPVSANSSLQ NHSNVLNFTP 480
  481 ATNSSTSSRK SGSNKINSNA SHSNHTGANT HAGSSSSSSS VNYSSNNNVS SSSAKRYSSS 540
  541 NLNPNNSSGY SYSSKRNRSN AYSSTNSPTH ANSFSSNRNY ELAKRIIHTW WIYTLKLLTW 600
  601 LFYLVYDIVV LGFSMGYERI TLAYVAALAY ARQLQKELKQ NSGKPSIWWR SYWRRFDARF 660
  661 AKNSRLAVWR LFYKRKPPET TSEQFKTGRL PQTGEEAMYS LLNCKGKDAY SILGVPPDSS 720
  721 QEQIRKHYKK IAVLVHPDKN KQAGAEEAFK VLQRAFELIG EPENRLIYDQ SIAETLHTEK 780
  781 AWTELHDLLS QLQTKMAEAA NTIRCSTCAQ RHPRKLTERP HYAARECASC KIRHSAKDGD 840
  841 IWAETSMMGL RWKYLALMDG KVYDITEWAN CQKGALSHLE PNSHMVQYRI VRGAQQQQQQ 900
  901 QQQQQQQQQQ QHHQHPQQPH HDRGVHHPGG GVSGVSEATL HEFLDNLYSG QHPGAHNAFA 960
  961 GNARRRTRRN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..243] MSA 3.244994 View MSA. No confident structure predictions are available.
    2 View Details [244..453] MSA 1.242984 View MSA. No confident structure predictions are available.
    3 View Details [454..547] MSA 3.190986 View MSA. No confident structure predictions are available.
    4 View Details [548..609] deduced N/A No confident structure predictions are available.
    5 View Details [610..704] PSI-BLAST 5.0 Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90
    6 View Details [705..781] PSI-BLAST 41.69897 NMR STRUCTURE OF THE J-DOMAIN (RESIDUES 2-76) IN THE ESCHERICHIA COLI N-TERMINAL FRAGMENT (RESIDUES 2-108) OF THE MOLECULAR CHAPERONE DNAJ, 20 STRUCTURES
    7 View Details [782..970] PSI-BLAST 40.154902 The crystal structure of Hsp40 Ydj1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • catalytic activity
    		•  0.489294356963286 bayes_pls_golite062009
    6
    Term Confidence Notes
  • binding
    		•  0.737868215447232 bayes_pls_golite062009
  • protein binding
    		•  0.638532996829248 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.54782901815678 bayes_pls_golite062009
    7
    Term Confidence Notes
  • binding
    		•  0.836371661677598 bayes_pls_golite062009
  • protein binding
    		•  0.608423478560768 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle