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Protein Overview: Su(var)3-3-PB, S...

General Information:
Name(s) found: Su(var)3-3-PB / FBpp0074595 [FlyBase]
Su(var)3-3-PA / FBpp0074594 [FlyBase]
Description(s) found:
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  • gi|75027620|sp|Q9VW97.1|LSDA_DROME RecName: Full=Possible lysine-specific histone demethylase 1 [NCBI NR]
  • gi|7293682|gb|AAF49052.1| histone demethylase, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|7293681|gb|AAF49051.1| histone demethylase, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|24667273|ref|NP_730497.1| histone demethylase, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|21356479|ref|NP_649194.1| histone demethylase, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|20151661|gb|AAM11190.1| LD45081p [Drosophila melanogaster] [NCBI NR]
  • Possible lysine-specific histone demethylase 1 OS=Drosophila melanogaster GN=Su(var)3-3 PE=1 SV=1 [Swiss-Prot]
  • The gene Suppressor of variegation 3-3 is referred to in FlyBase by the symbol Dmel\Su(var)3-3 (CG17149, FBgn0260397). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:20219517..20223351. It has the cytological map location 77A3. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: oxidoreductase activity; FAD binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: oxidation reduction; histone demethylation; regulation of transcription. 33 alleles are reported. The phenotype of these alleles is annotated with: wing. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG17149-PA translation from_gene[CG17149 CG17149 FBgn0036955] seq_release:3 mol_weight=98390 cds_boundaries:(3L:20,145,354..20,148,212[+]) aa_length:890 transcript_info:[CG17149-RA seq_release:3] gene_info:[gene symbol:CG17149 FBgn0036955 gene_boundar [hmr_yeast5_DM3-1_pombe.fasta]
  • >CG17149-PB translation from_gene[CG17149 CG17149 FBgn0036955] seq_release:3 mol_weight=98390 cds_boundaries:(3L:20,145,354..20,148,212[+]) aa_length:890 transcript_info:[CG17149-RB seq_release:3] gene_info:[gene symbol:CG17149 FBgn0036955 gene_boundar [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VW97) CG17149 protein (LD45081p) [DrosMelano7227.FASTAC.txt]
  • (AE003514) CG17149 gene product [alt 2] [Drosophila melanogaster] [yeastflysequest.fasta]
  • (AE003514) CG17149 gene product [alt 1] [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG17149-PB, isoform B [Drosophila melanogaster]gi|7293682|gb|AAF49052.1| CG17149-PA, isoform A [Drosophila melanogaster]gi|20151661|gb|AAM11190.1| LD45081p [Drosophila melanogaster]gi|24667273|ref|NP_730497.1| CG17149-PB [Drosophila melanogaster]gi|21 [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3L:join(20219916..20221444,20221517..20222055,20222173..20222777); ID=FBpp0074594; name=Su(var)3-3-PA; parent=FBgn0260397,FBtr0074825; dbxref=FlyBase:FBpp0074594,FlyBase_Annotation_IDs:CG17149-PA,GB_protein:AAF49052.1,REFSEQ:NP_649194,GB [fly-100309-contam.fasta]
  • type=protein; loc=3L:join(20219916..20221444,20221517..20222055,20222173..20222777); ID=FBpp0074595; name=Su(var)3-3-PB; parent=FBgn0260397,FBtr0074826; dbxref=FlyBase:FBpp0074595,FlyBase_Annotation_IDs:CG17149-PB,GB_protein:AAF49051.1,REFSEQ:NP_730497,GB [fly-100309-contam.fasta]
  • Possible lysine-specific histone demethylase 1 [nr-271106-contam.fasta]
  • CG17149-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • LD45081p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG17149-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3L:join(20219916..20221444,20221517..20222055,20222173..20222777); ID=FBpp0074594; name=Su(var)3-3-PA; parent=FBgn0260397,FBtr0074825; dbxref=FlyBase:FBpp0074594,FlyBase_Annotation_IDs:CG17149-PA,GB_protein:AAF49052.1,REFSEQ:NP_649194,GB_protein:AAF49052; MD5=686a1c795db13cf5cfe479a448ba2ece; length=890; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3L:join(20219916..20221444,20221517..20222055,20222173..20222777); ID=FBpp0074595; name=Su(var)3-3-PB; parent=FBgn0260397,FBtr0074826; dbxref=FlyBase:FBpp0074595,FlyBase_Annotation_IDs:CG17149-PB,GB_protein:AAF49051.1,REFSEQ:NP_730497,GB_protein:AAF49051; MD5=686a1c795db13cf5cfe479a448ba2ece; length=890; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3L:join(20219916..20221444,20221517..20222055,20222173..20222777); ID=FBpp0074594; name=Su(var)3-3-PA; parent=FBgn0260397,FBtr0074825; dbxref=FlyBase:FBpp0074594,FlyBase_Annotation_IDs:CG17149-PA,GB_protein:AAF49052.1,REFSEQ:NP_649194,GB_protein:AAF49052; MD5=686a1c795db13cf5cfe479a448ba2ece; length=890; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3L:join(20219916..20221444,20221517..20222055,20222173..20222777); ID=FBpp0074595; name=Su(var)3-3-PB; parent=FBgn0260397,FBtr0074826; dbxref=FlyBase:FBpp0074595,FlyBase_Annotation_IDs:CG17149-PB,GB_protein:AAF49051.1,REFSEQ:NP_730497,GB_protein:AAF49051; MD5=686a1c795db13cf5cfe479a448ba2ece; length=890; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Suppressor of variegation 3-3, isoform B OS=Drosophila melanogaster GN=Su(var)3-3 PE=4 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3L:join(20219916..20221444,20221517..20222055,20222173..20222777); ID=FBpp0074594; name=Su(var)3-3-PA; parent=FBgn0260397,FBtr0074825; dbxref=FlyBase:FBpp0074594,FlyBase_Annotation_IDs:CG17149-PA,GB_protein:AAF49052.1,REFSEQ:NP_649194,GB_protein:AAF49052,FlyMine:FBpp0074594,modMine:FBpp0074594; MD5=686a1c795db13cf5cfe479a448ba2ece; length=890; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3L:join(20219916..20221444,20221517..20222055,20222173..20222777); ID=FBpp0074595; name=Su(var)3-3-PB; parent=FBgn0260397,FBtr0074826; dbxref=FlyBase:FBpp0074595,FlyBase_Annotation_IDs:CG17149-PB,GB_protein:AAF49051.1,REFSEQ:NP_730497,GB_protein:AAF49051; MD5=686a1c795db13cf5cfe479a448ba2ece; length=890; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3L:join(20226816..20228344,20228417..20228955,20229073..20229677); ID=FBpp0074594; name=Su(var)3-3-PA; parent=FBgn0260397,FBtr0074825; dbxref=FlyBase:FBpp0074594,FlyBase_Annotation_IDs:CG17149-PA,GB_protein:AAF49052.1,REFSEQ:NP_649194,GB_protein:AAF49052,FlyMine:FBpp0074594,modMine:FBpp0074594; MD5=686a1c795db13cf5cfe479a448ba2ece; length=890; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3L:join(20226816..20228344,20228417..20228955,20229073..20229677); ID=FBpp0074595; name=Su(var)3-3-PB; parent=FBgn0260397,FBtr0074826; dbxref=FlyBase:FBpp0074595,FlyBase_Annotation_IDs:CG17149-PB,GB_protein:AAF49051.1,REFSEQ:NP_730497,GB_protein:AAF49051; MD5=686a1c795db13cf5cfe479a448ba2ece; length=890; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3L:join(20226816..20228344,20228417..20228955,20229073..20229677); ID=FBpp0074594; name=Su(var)3-3-PA; parent=FBgn0260397,FBtr0074825; dbxref=FlyBase:FBpp0074594,FlyBase_Annotation_IDs:CG17149-PA,GB_protein:AAF49052.1,REFSEQ:NP_649194,GB_protein:AAF49052,FlyMine:FBpp0074594,modMine:FBpp0074594; MD5=686a1c795db13cf5cfe479a448ba2ece; length=890; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=3L:join(20226816..20228344,20228417..20228955,20229073..20229677); ID=FBpp0074595; name=Su(var)3-3-PB; parent=FBgn0260397,FBtr0074826; dbxref=FlyBase:FBpp0074595,FlyBase_Annotation_IDs:CG17149-PB,GB_protein:AAF49051.1,REFSEQ:NP_730497,GB_protein:AAF49051; MD5=686a1c795db13cf5cfe479a448ba2ece; length=890; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q9VW97, Suppressor of variegation 3-3, isoform B OS=Drosophila melanogaster GN=Su(var)3-3 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0074594 type=protein; loc=3L:join(20226816..20228344,20228417..20228955,20229073..20229677); ID=FBpp0074594; name=Su(var)3-3-PA; parent=FBgn0260397,FBtr0074825; dbxref=FlyBase:FBpp0074594,FlyBase_Annotation_IDs:CG17149-PA,GB_protein:AAF49052.1,REFSEQ:NP_649194,GB_protein:AAF49052,FlyMine:FBpp0074594,modMine:FBpp0074594; MD5=686a1c795db13cf5cfe479a448ba2ece; length=890; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0074595 type=protein; loc=3L:join(20226816..20228344,20228417..20228955,20229073..20229677); ID=FBpp0074595; name=Su(var)3-3-PB; parent=FBgn0260397,FBtr0074826; dbxref=FlyBase:FBpp0074595,FlyBase_Annotation_IDs:CG17149-PB,GB_protein:AAF49051.1,REFSEQ:NP_730497,GB_protein:AAF49051; MD5=686a1c795db13cf5cfe479a448ba2ece; length=890; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3L:join(20226816..20228344,20228417..20228955,20229073..20229677); ID=FBpp0074594; name=Su(var)3-3-PA; parent=FBgn0260397,FBtr0074825; dbxref=FlyBase:FBpp0074594,FlyBase_Annotation_IDs:CG17149-PA,GB_protein:AAF49052.1,REFSEQ:NP_649194,GB_protein:AAF49052,UniProt/Swiss-Prot:Q9VW97,FlyMine:FBpp0074594,modMine:FBpp0074594; MD5=686a1c795db13cf5cfe479a448ba2ece; length=890; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=3L:join(20226816..20228344,20228417..20228955,20229073..20229677); ID=FBpp0074595; name=Su(var)3-3-PB; parent=FBgn0260397,FBtr0074826; dbxref=FlyBase:FBpp0074595,FlyBase_Annotation_IDs:CG17149-PB,GB_protein:AAF49051.1,REFSEQ:NP_730497,GB_protein:AAF49051,UniProt/Swiss-Prot:Q9VW97; MD5=686a1c795db13cf5cfe479a448ba2ece; length=890; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 890 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    Biological Process: oxidation reduction [IEA]
    regulation of transcription [IEA]
    histone demethylation [IEA]
    Molecular Function: FAD binding [IEA]
    oxidoreductase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPTQFGGSS SKMTEPIEYV TLISDDSDGE PTPKRNVNHP PSALSAPNPG QKQKHPDEDS  60
   61 NDAPATSDER RTSRRNRPKV DYSNRPSGSG DTASNDKSGS ASMGPNNQQA ERRSQSQTRK 120
  121 SEANATSSSV SGPSAGNSRP SQNGDSKDRD AGTPTVLSGQ EGAVFQSRLP FNKMTPNEEA 180
  181 CFPDISRSGI LGHRVFLNIR NSLLHMWVDN PKIQLSFEIA LKNLPPPFDS EPSLVRRVHS 240
  241 FLERHGFINF GIFKRLKPIP AKKLGKVIVI GAGISGLAVA HQLQQFGMDV IVLEARDRVG 300
  301 GRISTFRKNS YIADVGAMVV TGVYGNPMTI LSKQIGMDLV PIQQTCPLYG PDGKPVPKEK 360
  361 DDVIEREFNR LLESASYLSH RLDFNYAGDC PVSLGDALEW IISMQEMQVM HKRGQHMQEI 420
  421 IATQTKIIEQ RRRLKTLRDT IGKLKNEHLA MINQRKPKGT DGDLKYCYQE FNIRNTQIKM 480
  481 EETISTFHDL HAEEKQMLAK LHELEQNRPS DVYLSSRDRL ILDWHFANLE FANATRLNNL 540
  541 SLKHWDQDDD FEFIGHHTTV RNGYSCVPVA LTENLDIRVN SAVKEIKYGT KGVEVVAENL 600
  601 KTSNSQMTYK ADLVVCTLTL GVLKVAVAHK ESQQSNTVKF DPPLPDWKQQ AIKRLGFGNL 660
  661 NKVVLCFDRI FWDPNANLFG HVGSTTASRG EMFLFWSISS SPVLLALVAG MAANLVESVT 720
  721 DDIIIGRCMS VLKNIFGNTS VPQPKETVVT RWRSDPWARG SYSYVSVGSS GSDYDLLAAP 780
  781 VIPPSSKDAE GLPRLFFAGE HTIRNYPATV HGAYLSGLRE AGRIADYYLG YPEGTPPDIG 840
  841 YSVAEAANLV SVGNVVKLRD LSPNLSDSSP SSKKSEENSN SNTADSTELQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.48

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle