Protein Overview: Nedd4-PK

General Information:
Name(s) found:	Nedd4-PK / FBpp0289747 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|24665984\|ref\|NP_730282.1\| Nedd4, isoform K [Drosophila melanogaster] [NCBI NR] gi\|23093227\|gb\|AAN11694.1\| Nedd4, isoform K [Drosophila melanogaster] [NCBI NR] gi\|16769848\|gb\|AAL29143.1\| SD04682p [Drosophila melanogaster] [NCBI NR] The gene Nedd4 is referred to in FlyBase by the symbol Dmel\Nedd4 (CG42279, FBgn0259174). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:17523183..17539760. It has the cytological map location 74D3. There is experimental evidence that it has the molecular function</span>: Notch binding; protein binding; protein domain specific binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of Notch signaling pathway; receptor internalization; positive regulation of receptor internalization; axon guidance; positive regulation of synaptogenesis; positive regulation of endocytosis; axon midline choice point recognition; protein ubiquitination. 43 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; wing vein L3; posterior commissure; anterior crossvein; longitudinal connective; embryonic central nervous system; wing; wing vein; anterior commissure. It has 7 annotated transcripts and 7 annotated polypeptides. [FlyBase] >CG7555-PC translation from_gene[CG7555 Nedd4 FBgn0036736] seq_release:3 mol_weight=95304 cds_boundaries:(3L:17,479,726..17,494,486[+]) aa_length:834 transcript_info:[CG7555-RC seq_release:3] gene_info:[gene symbol:Nedd4 FBgn0036736 gene_boundaries:(3L [hmr_yeast5_DM3-1_pombe.fasta] (Q95R64) SD04682p (CG7555-PC) [DrosMelano7227.FASTAC.txt] CG7555-PC, isoform C [Drosophila melanogaster]gi\|16769848\|gb\|AAL29143.1\| SD04682p [Drosophila melanogaster]gi\|24665984\|ref\|NP_730282.1\| CG7555-PC [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=3L:join(17523947..17524135,17531762..17531844,17531914..17531995,17532556..17532594,17532667..17532836,17533791..17533938,17534002..17534126,17534401..17534503,17536605..17536712,17536864..17537101,17537160..17537284,17537356..17537497,1 [fly-100309-contam.fasta] Nedd4 CG7555-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] CG7555-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] SD04682p [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3L:join(17523947..17524135,17531762..17531844,17531914..17531995,17532556..17532594,17532667..17532836,17533791..17533938,17534002..17534126,17534401..17534503,17536605..17536712,17536864..17537101,17537160..17537284,17537356..17537497,17537561..17537717,17537777..17538070,17538135..17538533,17538608..17538710); ID=FBpp0289747; name=Nedd4-PK; parent=FBgn0259174,FBtr0300520; dbxref=FlyBase:FBpp0289747,FlyBase_Annotation_IDs:CG42279-PK,REFSEQ:NP_730282,GB_protein:AAN11694; MD5=da3c808d34b340bf12fe16462433be24; length=834; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3L:join(17523947..17524135,17531762..17531844,17531914..17531995,17532556..17532594,17532667..17532836,17533791..17533938,17534002..17534126,17534401..17534503,17536605..17536712,17536864..17537101,17537160..17537284,17537356..17537497,17537561..17537717,17537777..17538070,17538135..17538533,17538608..17538710); ID=FBpp0289747; name=Nedd4-PK; parent=FBgn0259174,FBtr0300520; dbxref=FlyBase:FBpp0289747,FlyBase_Annotation_IDs:CG42279-PK,REFSEQ:NP_730282,GB_protein:AAN11694; MD5=da3c808d34b340bf12fe16462433be24; length=834; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Isoform 3 of E3 ubiquitin-protein ligase Nedd-4 OS=Drosophila melanogaster GN=Nedd4 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=3L:join(17523947..17524135,17531762..17531844,17531914..17531995,17532556..17532594,17532667..17532836,17533791..17533938,17534002..17534126,17534401..17534503,17536605..17536712,17536864..17537101,17537160..17537284,17537356..17537497,17537561..17537717,17537777..17538070,17538135..17538533,17538608..17538710); ID=FBpp0289747; name=Nedd4-PK; parent=FBgn0259174,FBtr0300520; dbxref=FlyBase:FBpp0289747,FlyBase_Annotation_IDs:CG42279-PK,REFSEQ:NP_730282,GB_protein:AAN11694,FlyMine:FBpp0289747,modMine:FBpp0289747; MD5=da3c808d34b340bf12fe16462433be24; length=834; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3L:join(17530847..17531035,17538662..17538744,17538814..17538895,17539456..17539494,17539567..17539736,17540691..17540838,17540902..17541026,17541301..17541403,17543505..17543612,17543764..17544001,17544060..17544184,17544256..17544397,17544461..17544617,17544677..17544970,17545035..17545433,17545508..17545610); ID=FBpp0289747; name=Nedd4-PK; parent=FBgn0259174,FBtr0300520; dbxref=FlyBase:FBpp0289747,FlyBase_Annotation_IDs:CG42279-PK,REFSEQ:NP_730282,GB_protein:AAN11694,FlyMine:FBpp0289747,modMine:FBpp0289747; MD5=da3c808d34b340bf12fe16462433be24; length=834; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3L:join(17530847..17531035,17538662..17538744,17538814..17538895,17539456..17539494,17539567..17539736,17540691..17540838,17540902..17541026,17541301..17541403,17543505..17543612,17543764..17544001,17544060..17544184,17544256..17544397,17544461..17544617,17544677..17544970,17545035..17545433,17545508..17545610); ID=FBpp0289747; name=Nedd4-PK; parent=FBgn0259174,FBtr0300520; dbxref=FlyBase:FBpp0289747,FlyBase_Annotation_IDs:CG42279-PK,REFSEQ:NP_730282,GB_protein:AAN11694,FlyMine:FBpp0289747,modMine:FBpp0289747; MD5=da3c808d34b340bf12fe16462433be24; length=834; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Isoform of Q9VVI3, Isoform 3 of E3 ubiquitin-protein ligase Nedd-4 OS=Drosophila melanogaster GN=Nedd4 [DROME.fasta.20160308] FBpp0289747 type=protein; loc=3L:join(17530847..17531035,17538662..17538744,17538814..17538895,17539456..17539494,17539567..17539736,17540691..17540838,17540902..17541026,17541301..17541403,17543505..17543612,17543764..17544001,17544060..17544184,17544256..17544397,17544461..17544617,17544677..17544970,17545035..17545433,17545508..17545610); ID=FBpp0289747; name=Nedd4-PK; parent=FBgn0259174,FBtr0300520; dbxref=FlyBase:FBpp0289747,FlyBase_Annotation_IDs:CG42279-PK,REFSEQ:NP_730282,GB_protein:AAN11694,FlyMine:FBpp0289747,modMine:FBpp0289747; MD5=da3c808d34b340bf12fe16462433be24; length=834; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3L:join(17530847..17531035,17538662..17538744,17538814..17538895,17539456..17539494,17539567..17539736,17540691..17540838,17540902..17541026,17541301..17541403,17543505..17543612,17543764..17544001,17544060..17544184,17544256..17544397,17544461..17544617,17544677..17544970,17545035..17545433,17545508..17545610); ID=FBpp0289747; name=Nedd4-PK; parent=FBgn0259174,FBtr0300520; dbxref=FlyBase:FBpp0289747,FlyBase_Annotation_IDs:CG42279-PK,REFSEQ:NP_730282,GB_protein:AAN11694,FlyMine:FBpp0289747,modMine:FBpp0289747; MD5=da3c808d34b340bf12fe16462433be24; length=834; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	834 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSARSSGLVA AAALPVPSSS SSVAGGDVPR PPPRRRAASV AGQQQTRQEF GNGYTPRRSL  60
   61 AAVNDSGDSC HLRIVVLTGQ SLAKKDIFGA SDPYVRIDLN TINGDINIDS VLTKTKKKTL 120
  121 NPTWNEEFIF RVKPSEHKLV FQVFDENRLT RDDFLGMVEL TLVNLPTEQE GRTIGEQSYT 180
  181 LRPRRSVGAK SRIKGTLRIY HAFIRETREQ SEPSSGNSDG EWEHVEATNA GETSAQPHPF 240
  241 PTGGHDALPA GWEERQDANG RTYYVNHTAR TTQWDRPTVL NSHSSQSTDD QLASDFQRRF 300
  301 HISVDDTESG RSANEDTDHT DSHNPSDISA PSTRRNSEED NAAVPPMEQN TGGEEEPLPP 360
  361 RWSMQVAPNG RTFFIDHASR RTTWIDPRNG RASPMPNQTR RVEDDLGPLP EGWEERVHTD 420
  421 GRVFYIDHNT RTTQWEDPRL SNPNIAGQAV PYSRDYKQKY EYFKSHIRKP TNVPNKFEIR 480
  481 IRRTSILEDS YRIISSVTKT DLLKTKLWVE FEGETGLDYG GLAREWFYLL SKEMFNPYYG 540
  541 LFEYSAMDNY TLQINNGSGL CNEEHLSYFK FIGRIAGMAV YHGKLLDAFF IRPFYKMMLQ 600
  601 KPIDLKDMES VDTEYYNSLM WIKENDPRIL ELTFCLDEDV FGQKSQHELK PGGANIDVTN 660
  661 ENKDEYIKLV IEWRFVARVK EQMSSFLDGF GSIIPLNLIK IFDEHELELL MCGIQNIDVK 720
  721 DWRENTLYKG DYHMNHIIIQ WFWRAVLSFS NEMRSRLLQF VTGTSRVPMN GFKELYGSNG 780
  781 PQMFTIEKWG TPNNFPRAHT CFNRLDLPPY EGYLQLKDKL IKAIEGSQGF AGVD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: Nedd4-PK

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: