Protein Overview: Srp68-PA

General Information:
Name(s) found:	Srp68-PA / FBpp0076244 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7295013\|gb\|AAF50341.1\| Srp68 [Drosophila melanogaster] [NCBI NR] gi\|21355591\|ref\|NP_648273.1\| Srp68 [Drosophila melanogaster] [NCBI NR] gi\|16198221\|gb\|AAL13927.1\| LD41750p [Drosophila melanogaster] [NCBI NR] gi\|12230644\|sp\|Q9VSS2.1\|SRP68_DROME RecName: Full=Signal recognition particle 68 kDa protein; Short=SRP68 [NCBI NR] Signal recognition particle subunit SRP68 OS=Drosophila melanogaster GN=Srp68 PE=2 SV=1 [Swiss-Prot] (Q9VSS2) Probable signal recognition particle 68 kDa protein (SRP68) [Swiss-Prot] The gene Srp68 is referred to in FlyBase by the symbol Dmel\Srp68 (CG5064, FBgn0035947). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:8968148..8970510. It has the cytological map location 66E6. Based on sequence similarity, it is predicted to have molecular function</span>: 7S RNA binding; mRNA binding. There is experimental evidence that it is involved in the biological process</span>: lysosome organization; negative regulation of autophagy. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG5064-PA translation from_gene[CG5064 CG5064 FBgn0035947] seq_release:3 mol_weight=69010 cds_boundaries:(3L:8,933,834..8,935,869[+]) aa_length:604 transcript_info:[CG5064-RA seq_release:3] gene_info:[gene symbol:CG5064 FBgn0035947 gene_boundaries:(3L [hmr_yeast5_DM3-1_pombe.fasta] (AE003553) CG5064 gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG5064-PA [Drosophila melanogaster]gi\|16198221\|gb\|AAL13927.1\| LD41750p [Drosophila melanogaster]gi\|21355591\|ref\|NP_648273.1\| CG5064-PA [Drosophila melanogaster]gi\|12230644\|sp\|Q9VSS2\|SR68_DROME Probable signal recognition particle 68 kDa protein (SRP68) [nrdb_11152004_Chlamydomonas] type=protein; loc=3L:join(8968224..8968320,8968425..8968774,8968837..8969499,8969558..8970262); ID=FBpp0076244; name=Srp68-PA; parent=FBgn0035947,FBtr0076517; dbxref=FlyBase:FBpp0076244,FlyBase_Annotation_IDs:CG5064-PA,GB_protein:AAF50341.1,REFSEQ:NP_6482 [fly-100309-contam.fasta] Probable signal recognition particle 68 kDa protein (SRP68) [nr-271106-contam.fasta] LD41750p [Drosophila melanogaster] [nr-271106-contam.fasta] Srp68 CG5064-PA [Drosophila melanogaster] [nr-271106-contam.fasta] CG5064-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3L:join(8968224..8968320,8968425..8968774,8968837..8969499,8969558..8970262); ID=FBpp0076244; name=Srp68-PA; parent=FBgn0035947,FBtr0076517; dbxref=FlyBase:FBpp0076244,FlyBase_Annotation_IDs:CG5064-PA,GB_protein:AAF50341.1,REFSEQ:NP_648273,GB_protein:AAF50341; MD5=12e8592eab7f4ecbf4efb7728e6c8c6b; length=604; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3L:join(8968224..8968320,8968425..8968774,8968837..8969499,8969558..8970262); ID=FBpp0076244; name=Srp68-PA; parent=FBgn0035947,FBtr0076517; dbxref=FlyBase:FBpp0076244,FlyBase_Annotation_IDs:CG5064-PA,GB_protein:AAF50341.1,REFSEQ:NP_648273,GB_protein:AAF50341; MD5=12e8592eab7f4ecbf4efb7728e6c8c6b; length=604; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Signal recognition particle 68 kDa protein OS=Drosophila melanogaster GN=Srp68 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=3L:join(8968224..8968320,8968425..8968774,8968837..8969499,8969558..8970262); ID=FBpp0076244; name=Srp68-PA; parent=FBgn0035947,FBtr0076517; dbxref=FlyBase:FBpp0076244,FlyBase_Annotation_IDs:CG5064-PA,GB_protein:AAF50341.1,REFSEQ:NP_648273,GB_protein:AAF50341,FlyMine:FBpp0076244,modMine:FBpp0076244; MD5=12e8592eab7f4ecbf4efb7728e6c8c6b; length=604; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] Signal recognition particle 68 kDa protein OS=Drosophila melanogaster GN=Srp68 PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta] type=protein; loc=3L:join(8975124..8975220,8975325..8975674,8975737..8976399,8976458..8977162); ID=FBpp0076244; name=Srp68-PA; parent=FBgn0035947,FBtr0076517; dbxref=FlyBase:FBpp0076244,FlyBase_Annotation_IDs:CG5064-PA,GB_protein:AAF50341.1,REFSEQ:NP_648273,GB_protein:AAF50341,FlyMine:FBpp0076244,modMine:FBpp0076244; MD5=12e8592eab7f4ecbf4efb7728e6c8c6b; length=604; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3L:join(8975124..8975220,8975325..8975674,8975737..8976399,8976458..8977162); ID=FBpp0076244; name=Srp68-PA; parent=FBgn0035947,FBtr0076517; dbxref=FlyBase:FBpp0076244,FlyBase_Annotation_IDs:CG5064-PA,GB_protein:AAF50341.1,REFSEQ:NP_648273,GB_protein:AAF50341,FlyMine:FBpp0076244,modMine:FBpp0076244; MD5=12e8592eab7f4ecbf4efb7728e6c8c6b; length=604; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0076244 type=protein; loc=3L:join(8975124..8975220,8975325..8975674,8975737..8976399,8976458..8977162); ID=FBpp0076244; name=Srp68-PA; parent=FBgn0035947,FBtr0076517; dbxref=FlyBase:FBpp0076244,FlyBase_Annotation_IDs:CG5064-PA,GB_protein:AAF50341.1,REFSEQ:NP_648273,GB_protein:AAF50341,FlyMine:FBpp0076244,modMine:FBpp0076244; MD5=12e8592eab7f4ecbf4efb7728e6c8c6b; length=604; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3L:join(8975124..8975220,8975325..8975674,8975737..8976399,8976458..8977162); ID=FBpp0076244; name=Srp68-PA; parent=FBgn0035947,FBtr0076517; dbxref=FlyBase:FBpp0076244,FlyBase_Annotation_IDs:CG5064-PA,GB_protein:AAF50341.1,REFSEQ:NP_648273,GB_protein:AAF50341,UniProt/Swiss-Prot:Q9VSS2,FlyMine:FBpp0076244,modMine:FBpp0076244; MD5=12e8592eab7f4ecbf4efb7728e6c8c6b; length=604; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	604 amino acids
Gene Ontology:
Cellular Component:	signal recognition particle, endoplasmic reticulum targeting [ISS]
Biological Process:	lysosome organization [IMP] SRP-dependent cotranslational protein targeting to membrane [ISS] negative regulation of autophagy [IMP]
Molecular Function:	7S RNA binding [ISS] mRNA binding [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVQEDNPNT GDVQEKTETA PVAEPSKIFT VEILHMIKDA QQQHGLRHGD FQRYRGYCSR  60
   61 RIRRLRKALK YPQGDKRHFK RRDVTIGQLT GKKADERFIH IPLICAERAW AYAMQLKQES 120
  121 NTEPRKRFHL VNKLRRACFY ALQLQELCNT EAFDARTKLE CEAYVAWMHG TLHFELQLWK 180
  181 TAGEHLKRAQ VVYENLGKAL PEDEQELYRA KVNEFTPNLR YCAYNISGGA SGGKIDEILE 240
  241 LRAQGVLENL DVLVSQTKTE SSEGLQTIDW RGRKVTVRPE KVRLFLLSAQ ELDKSLAKTT 300
  301 KQDAKIELIE RILMDCKDAI QAVRDEIKQD PKLRSLTTGQ TVSGVQYLLA YLSYIRHSRT 360
  361 LQRNLCLVEQ AKLNFYDPNL QSQQNVGDGK RVRPQDLARL YEIILQNVTE MQQINGLEDD 420
  421 ATYQSEVENL AITFKAFRCY YIALTLIDIK KWKEAVALYE RASNYATEAL KGKSSPEFQL 480
  481 QEELKKVVSA IDGCKFSAHA YSVLEDDNSE ESGTTTKSQK TTKPLYERLS LYKEDQSLHT 540
  541 KAPNVFKLTP DMEPIPCKPI FFDLAMTYVE LPSLEGKLES PGKKGASITG FVKGFLGWGG 600
  601 GGNK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: Srp68-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: