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Protein Overview: lox2-PA

General Information:
Name(s) found: lox2-PA / FBpp0071659 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene lysyl oxidase-like 2 is referred to in FlyBase by the symbol Dmel\lox2 (CG4402, FBgn0034660). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:17677121..17679160. It has the cytological map location 58A1. Based on sequence similarity, it is predicted to have molecular function</span>: protein-lysine 6-oxidase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: cell adhesion; protein modification process. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 511 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    Biological Process: protein modification process [ISS]
    oxidation reduction [IEA]
    cell adhesion [ISS]
    Molecular Function: copper ion binding [IEA]
    scavenger receptor activity [IEA]
    protein-lysine 6-oxidase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCAIEDRKVL KMGLTLVCLT LLAIHMADAV VQHRSLEDAR QERQRLVHRY TKVLNKEEGA  60
   61 IRLVGGDNEY EGNIEVLHNG KWGAVCDDEW DSTEADIVCR QLGFPGMRRY TRSGFFGPAR 120
  121 RRFWMDNLFC EGHEQELVDC HFEGWGENDC EPGEAAGVVC YPPENALIPM ATPIIRDEDL 180
  181 PKYPIHSRSR LYVRLRGGRS RIEGRVEVSL DGGRWGSVCA DGWSLLEANV VCRQLGLGYA 240
  241 SEAFQTDFFG GFNVSRPVLS GSECYGNETE LADCLHHDAS QGIISCHGNR QHVAAVICDY 300
  301 IAPDLVVDYL EIEQTAHLED RPMLLMQCAM EENCVANEAY QIQRDDPHWR YRSRRLLKFT 360
  361 AAAINAGNAD FRPFKEKSQW EWHMCHMHFH SMEVFATFDI FNLRGIKVAQ GHKASFCLED 420
  421 SNCLPGVAKK YNCANYGDQG ISINCSDVYL YNLDCQWVDV TDLIPGTYVL KIAINPEFKV 480
  481 AEMNYDNNAA ICDLIYTANF ARVQNCQLGR P

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..172] PSI-BLAST 34.154902 STRUCTURE OF M2BP SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN
    2 View Details [173..286] FFAS03 5.17 STRUCTURE OF M2BP SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN
    3 View Details [287..372] PSI-BLAST 4.09691 No description for 2ja4A was found.
    4 View Details [373..511] MSA 1.216975 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  0.552410974340988 bayes_pls_golite062009
  • binding
    		•  0.536923542644072 bayes_pls_golite062009
  • catalytic activity
    		•  0.43947186099223 bayes_pls_golite062009
  • receptor activity
    		•  0.0495857193797902 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  0.490715949785074 bayes_pls_golite062009
  • catalytic activity
    		•  0.474271982951055 bayes_pls_golite062009
  • protein binding
    		•  0.471820641297956 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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