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Protein Overview: ASPP-PB

General Information:
Name(s) found: ASPP-PB / FBpp0071549 [FlyBase]
Description(s) found:
Found 18 descriptions.
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  • The gene Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein is referred to in FlyBase by the symbol Dmel\ASPP (CG18375, FBgn0034606). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:17105361..17138458. It has the cytological map location 57D2-57D4. There is experimental evidence that it has the molecular function</span>: protein tyrosine kinase activator activity. The biological processes in which it is involved are not known. 14 alleles are reported. The phenotypes of these alleles are annotated with: eye; interommatidial bristle; wing; ommatidium. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1069 amino acids

    Gene Ontology:
    Cellular Component: adherens junction [IDA]
    Biological Process: NONE FOUND
    Molecular Function: protein tyrosine kinase activator activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLTCVCRPVS GNLPKMPPAS LMPAHRASAS SASSSTSSTA SLAFVSPTRG VVVTSEPKLN  60
   61 VPSRLTSAEL RAMALRQQQQ IDSQHQLLAT KEQRLRFLKS QEVRSAVASA EGERLRRLRE 120
  121 RVEAQESKLR RLRALRGQVD LQKTYNVTLS NDLDSIRALF SEKEKELSLA VAKVEALTRQ 180
  181 LEELRRDRRC PVNILTAAGN GVGGQSLPPQ ASRELEKLRR ELMYRNQLSL QQDARLHMQR 240
  241 EALQQRQAEL RSTDQRIYEL QTRLQRKKQA NTHHQQQQQQ QQQHQQQQHQ QQHQQTTVQQ 300
  301 QQQQQQQLHV QSAQLLAAAA AATAQQQQQH QQHQQQQQQQ QQQSASNLGK HGGVAALKQQ 360
  361 LLQKQVNQLA AAAAAAAAGR ARGNVAAVEP FIHTPQKSTI TSTASYLSGG MKHAAATANT 420
  421 NQQNQLIQDL THVKLGQNSG FFAGSVPVPV ASSSCESDES KLAKKLLAAP AKTEAELRKQ 480
  481 AQTEAMDSTT HIYAEVGPKK RDREAAAAAA AAAAAAAAAA QAAAEAANQA ATAAAASAIS 540
  541 PPATANASKI PKSTTSSSSS ASALISKLNQ QATAKESQDQ QQSQAKKNEI SVTSETLSER 600
  601 NTQQQLTVHS MPLGAISKSV ALAVSNASKP LQVQVSNVAV PPRKPISSVA PNSVSSGSSI 660
  661 PKMITYSPKV NRVAPNVVMT DPRPALPPKP SKMSPTEQPS PVEANTSGSA GGAGSGAASA 720
  721 STANKTQTAT FGLQSLNIND NLPIKAKPLT IRKQPLFEQP RLKSSQSSSN GQQKPPLLQL 780
  781 QNQRKSEPSA RQPTENLPDT SPQHSPSSES SADETDRMVA PSITTSQQET STSATSTTTT 840
  841 VTTSNIKERT GNGKPKLGRR VSFDPLALLL DASLEGELEL VKKTAMQVAN PSAANDEGIT 900
  901 ALHNAICAGH IDIVKFLVEF GCDVNAQDSD GWTPLHCAAS CNNLSMVKFL VESGACLFAS 960
  961 TLSDHETPAE KCEEDEEGFD GCSEYLYSIQ EKLGILHNGD VYAVFSYEAQ NGDELSFHVN1020
 1021 EPLIVLRKGD DAENEWWWAR NAAGEEGYVP RNLLGLYPRV PPHSPHFSD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..458] PSI-BLAST 22.045757 Heavy meromyosin subfragment
    2 View Details [459..656] deduced N/A No confident structure predictions are available.
    3 View Details [657..726] deduced N/A No confident structure predictions are available.
    4 View Details [727..999] PSI-BLAST 33.30103 Crystal Structure Analysis of homolog of oncoprotein gankyrin, an interactor of Rb and CDK4/6
    5 View Details [1000..1069] PSI-BLAST 40.09691 53BP2


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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