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Protein Overview: mei-W68-PA

General Information:
Name(s) found: mei-W68-PA / FBpp0085657 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene meiotic W68 is referred to in FlyBase by the symbol Dmel\mei-W68 (CG7753, FBgn0002716). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15343700..15347029. It has the cytological map location 56D9. Based on sequence similarity, it is predicted to have molecular function</span>: DNA topoisomerase (ATP-hydrolyzing) activity. There is experimental evidence that it is involved in the biological process</span>: reciprocal meiotic recombination; early meiotic recombination nodule assembly; late meiotic recombination nodule assembly. 13 alleles are reported. The phenotypes of these alleles are annotated with: early recombination nodule; late recombination nodule. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 331 amino acids

    Gene Ontology:
    Cellular Component: chromosome [IEA]
    Biological Process: reciprocal meiotic recombination [IMP][TAS]
    late meiotic recombination nodule assembly [IMP]
    DNA topological change [IEA]
    DNA metabolic process [IEA]
    meiotic DNA double-strand break formation [NAS]
    early meiotic recombination nodule assembly [IMP]
    Molecular Function: ATP binding [IEA]
    DNA topoisomerase (ATP-hydrolyzing) activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEFSENIER IALELLSNLV HGNATLSVPR NSSGNVISEY RRVSYNNRGS RHSFCVLIYM  60
   61 LSRVHRLQVR GGSFTVRGLY YDNPLLVRSQ SRIAEARLDV CRMLRTSPLS LGILAASKGL 120
  121 VAGDLRLLMT NGDVLDSSLY GGPLTLPTDP EKIDRIETLA EFVLIVEKES VFESLLSRNV 180
  181 FGTFERRFIL ITGKGYPDCC TRRIVHRLTE ENQLAAYILV DADPFGVEIM LVYRHGSKSM 240
  241 SFSSQGLTTP ALRWIGLHPS EIPALGTGAV ALVAGDNKKI NDLLARHDLE PGVRQELRML 300
  301 QDVQLKAEIE SVIDFLTDDY IPNKINRNLF L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..331] PSI-BLAST 83.522879 No description for 2q2eA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle