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Protein Overview: Spt5-PA

General Information:
Name(s) found: Spt5-PA / FBpp0085716 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene Spt5 is referred to in FlyBase by the symbol Dmel\Spt5 (CG7626, FBgn0040273). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:15324991..15329403. It has the cytological map location 56D5-56D7. It is reported to have molecular function</span>: transcription elongation regulator activity. There is experimental evidence that it is involved in the biological process</span>: mitotic spindle organization. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1078 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    nuclear exosome (RNase complex) [IPI]
    polytene chromosome puff [IDA]
    polytene chromosome interband [IDA]
    Biological Process: positive regulation of RNA elongation from RNA polymerase II promoter [IEA]
    transcription [NAS]
    mitotic spindle organization [IMP]
    Molecular Function: transcription elongation regulator activity [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDSEVSNMS DSGSEDGSIS NKSQRSARSK SRSRSRSGSR GSRSVSRSRS RSQSGHSRSG  60
   61 SESPQRRDNR GKSDESGEEE EEPPGEDIDS EEYDEEENDD HPRKKKKKER FGGFIIDEAE 120
  121 VDDEVDEDDE WEEGANEIGI VGNEIDELGP TARDIEIRRR GTNLWDTQKE DEIEEYLRKK 180
  181 YADESIAKRH FGDGGEEMSD EITQQTLLPG IKDPNLWMVK CRIGEEKATA LLLMRKYLTY 240
  241 LNTDDPLQIK SIIAPEGVKG YIYLEAYKQT HVKTCIDNVG NLRMGKWKQE MVPIKEMTDV 300
  301 LKVVKEQVGL KVKQWVRLKR GLYKDDIAQV DYVDLAQNQV HLKLLPRIDY TRMRGALRTT 360
  361 ATESDDSKRK KKRRPAAKPF DPEAVRAIGG EVHSDGDFLL FEGNRYSRKG FLYKNFTMSA 420
  421 ILSDGVKPTL AELERFEESP EEVNLEIMGT VKDDPTMAHS FSMGDNVEVC VGDLENLQAK 480
  481 IVAIDGTMIT VMPKHQDLKD PLIFKASELR KYFKTGDHAR VLAGRYEGET GLIIRVEPTR 540
  541 VVLVSDLTNH ELEVLPRDLQ LCSDVATGVD CLGQFQWGDM VQLDSQNVGV IVRLERENFH 600
  601 VLGMNGKCIE CKPTALHKRK ENRHTVALDA DQNQIRRRDV VKVMEGPHAG RSGEIKHLYR 660
  661 SLAFLHCRMY TENGGIFVCK TRHLQLAGGS KTTVSNAGIV GGLGFMSPRI QSPMHPSGGR 720
  721 GARGGARGGR GGFRVTRDRE ILGKTIKISG GPYKGAVGIV KDATESTARV ELHTSCQTIS 780
  781 VDRNHIAIVG VTGKEGSVST YGRTPARTPG YGAQTPSYTA AGSKTPLVGS QTPNWDTDTR 840
  841 TPYGTMTPSH DGSMTPRHGA WDPTANTTPA RNNDFDYSLE EPSPSPGYNP STPGYQMTSQ 900
  901 FAPQTPGTLY GSDRSYSPFN PSPSPAPSPY PVGYMNTPSP STYSPNTPGG IPQSPYNPQT 960
  961 PGASLDSSMG DWCTTDIEVR IHTHDDTDLV GQTGIIRTVS NGVCSVFLRQ EDRSVSIVSE1020
 1021 HLAPVLPCNG DEFKIIYGDD RESVGRVLSK DGDVFVCRIN EEIKLLPINF LCKMKSID

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..167] MSA 2.050978 View MSA. No confident structure predictions are available.
    2 View Details [168..346] PSI-BLAST 26.045757 No description for 2exuA was found.
    3 View Details [347..425] deduced N/A No confident structure predictions are available.
    4 View Details [426..526] FFAS03 2.92 No description for 2e6zA was found.
    5 View Details [527..553] PSI-BLAST 24.09691 No description for 2do3A was found.
    6 View Details [554..688] deduced N/A No confident structure predictions are available.
    7 View Details [689..1078] PSI-BLAST 12.39794 No description for 1y0fA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle