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Protein Overview: CG4853-PB, CG4853-PA

General Information:
Name(s) found: CG4853-PB / FBpp0086095 [FlyBase]
CG4853-PA / FBpp0086094 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG4853 (CG4853, FBgn0034230). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13401710..13404950. It has the cytological map location 54C1. Based on sequence similarity, it is predicted to have molecular function</span>: deoxyribonuclease activity; Ras guanyl-nucleotide exchange factor activity. There is experimental evidence that it is involved in the biological process</span>: mushroom body development. 3 alleles are reported. The phenotypes of these alleles are annotated with: mushroom body; antennal lobe. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • This gene is referred to in FlyBase by the symbol Dmel\CG4853 (CG4853, FBgn0034230). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:13401710..13404950. It has the cytological map location 54C1. Based on sequence similarity, it is predicted to have molecular function</span>: deoxyribonuclease activity; Ras guanyl-nucleotide exchange factor activity. There is experimental evidence that it is involved in the biological process</span>: mushroom body development. 3 alleles are reported. The phenotypes of these alleles are annotated with: mushroom body; antennal lobe. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 709 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: DNA repair [ISS]
    mushroom body development [IMP]
    regulation of small GTPase mediated signal transduction [IEA]
    DNA recombination [ISS]
    Molecular Function: deoxyribonuclease activity [ISS]
    Ras guanyl-nucleotide exchange factor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDEDILNAVE SLFGKDVKIV DCETSSSLQQ EEVLLVNGVP VKLDGLPADD ASAIKAALLE  60
   61 GQMPSVEHLN QLLFRAGLAQ QPIEVETSLT VKSSLTTTEE VLVSRNGQIL DERTVETKEN 120
  121 FNHQSHQKEI WHPVKQQSAL ARATPENALK YRTTSNSTFA SQATDSDERP VDPLGRQLNQ 180
  181 TFSNASLMSS SSAITGSDQV IGSVSSTTIG DKSSNISSCD SGHDGLFHSV SMSAPWSHPR 240
  241 DTLTDSLYCD IPSSADESDA VSILNTHLKI TEPFDCQTAP VYAKDIPKKG NLDSVVNLLI 300
  301 NNNTKDLRFA FLTTSRLFSP PHQLLSKIIA KIDNEEENVL RLLNEWLDTC PGDFSHELLL 360
  361 QELENKRNVK GLAAFLDGIP QALAQKDENG RSQLNNLLTK QSSASSLGRQ SSIKSLKRFA 420
  421 ANVYKTDNVL NNCSSAFELA HQLYAIEYAY LSQIRLEEFV EILEKDELKT CISQTKAGTL 480
  481 GSNCISQVTI DSYVQWFNQL SYLTATEILK LGKKSQRAQM IDFWVETALE CFNTGNFNSL 540
  541 MAILTALNLT AIARLKKTWA KVQTTKFEGL EHQMDPSSNF LNYRSTMKAA VWRSEREMAN 600
  601 EIERAIIPFF SLFLKDLHAI NESHETKLAN GYINFEKCLH LGTQLRNFGK WQRLDCPYEQ 660
  661 LPSVVSYLLK AEVLSEDLLM KASYESEPPE TGEEKDHYKT LKAARKSNT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..85] deduced N/A No confident structure predictions are available.
    2 View Details [86..247] MSA 7.185996 View MSA. No confident structure predictions are available.
    3 View Details [248..709] PSI-BLAST 84.39794 Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • enzyme regulator activity
    		•  1.5659750622955 bayes_pls_golite062009
  • binding
    		•  0.314382910346442 bayes_pls_golite062009
  • protein binding
    		•  0.167385485519274 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.0309302643519621 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle