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Protein Overview: DAT-PA

General Information:
Name(s) found: DAT-PA / FBpp0086271 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Dopamine transporter is referred to in FlyBase by the symbol Dmel\DAT (CG8380, FBgn0034136). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:12446062..12452763. It has the cytological map location 53C7-53C8. There is experimental evidence that it has the molecular function</span>: dopamine transmembrane transporter activity; cocaine binding. There is experimental evidence that it is involved in the biological process</span>: dopamine transport; circadian sleep/wake cycle. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 631 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [UNKNOWN][IEA]
    Biological Process: circadian sleep/wake cycle [IDA]
    neurotransmitter transport [IEA]
    dopamine transport [IDA]
    Molecular Function: dopamine transmembrane transporter activity [IDA][NAS]
    dopamine:sodium symporter activity [ISS]
    cocaine binding [IDA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPTGHISKS KTPTPHDNDN NSISDERETW SGKVDFLLSV IGFAVDLANV WRFPYLCYKN  60
   61 GGGAFLVPYG IMLVVGGIPL FYMELALGQH NRKGAITCWG RLVPLFKGIG YAVVLIAFYV 120
  121 DFYYNVIIAW SLRFFFASFT NSLPWTSCNN IWNTPNCRPF ESQNASRVPV IGNYSDLYAM 180
  181 GNQSLLYNET YMNGSSLDTS AVGHVEGFQS AASEYFNRYI LELNRSEGIH DLGAIKWDMA 240
  241 LCLLIVYLIC YFSLWKGIST SGKVVWFTAL FPYAVLLILL IRGLTLPGSF LGIQYYLTPN 300
  301 FSAIYKAEVW VDAATQVFFS LGPGFGVLLA YASYNKYHNN VYKDALLTSF INSATSFIAG 360
  361 FVIFSVLGYM AHTLGVRIED VATEGPGLVF VVYPAAIATM PASTFWALIF FMMLLTLGLD 420
  421 SSFGGSEAII TALSDEFPKI KRNRELFVAG LFSLYFVVGL ASCTQGGFYF FHLLDRYAAG 480
  481 YSILVAVFFE AIAVSWIYGT NRFSEDIRDM IGFPPGRYWQ VCWRFVAPIF LLFITVYGLI 540
  541 GYEPLTYADY VYPSWANALG WCIAGSSVVM IPAVAIFKLL STPGSLRQRF TILTTPWRDQ 600
  601 QSMAMVLNGV TTEVTVVRLT DTETAKEPVD V

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..631] PSI-BLAST 60.154902 Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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