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Protein Overview: CG8102-PA

General Information:
Name(s) found: CG8102-PA / FBpp0086526 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG8102 (CG8102, FBgn0034007). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:11184269..11185834. It has the cytological map location 51F3-51F4. Based on sequence similarity, it is predicted to have molecular function</span>: NADH dehydrogenase activity; NADH dehydrogenase (ubiquinone) activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: mitochondrial electron transport, NADH to ubiquinone. One allele is reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 481 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial respiratory chain complex I [ISS]
    Biological Process: mitochondrial electron transport, NADH to ubiquinone [ISS]
    Molecular Function: NADH dehydrogenase activity [ISS]
    FMN binding [IEA]
    NAD or NADH binding [IEA]
    NADH dehydrogenase (ubiquinone) activity [ISS]
    4 iron, 4 sulfur cluster binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRQKLKNYL PSVWEQQLRL VQTAKKAGGS KKLGPDRPPI IDPPKGYEPN CKTKFGPLDD  60
   61 CDRVFQNLYG RHDWRLHGAC QRGDWHRTAE LLEQGPEWIM KQVSKSGLRG RGGAGFYAGL 120
  121 KWEFLRQTKS EKVPKMVIVN CAEGEPGTCK DRDILRHEPH KLIEGILLVG VAMGCGRAIV 180
  181 YIRNRFYNEA CNLHFALAEA YHHGLLGNSV CGTGIKFDVM VQRGDRYLCG EETAMINCLM 240
  241 GKLGRPRRRP PFLTEKGYFE HPCLVINAES IAVVPTILRR GSQWWAGLGR SYNTGTKLYC 300
  301 LSGQVNNPCT VEEEMSIPLK DLIERHAGGV KGGWDNLAAV FPGGLSTPLL DPSTAGKVLM 360
  361 DFDSLTDAGS GFGCGAVIVM TKDCDPLAIM LRSIQFFEKH TCKQCSYCRD GAIWLPEIFA 420
  421 RFVKGQTHPH EIDWTLVIAD KMRNSKPICA LAYSQVSVAE SLVRMFSRKI EERLLKYAKG 480
  481 S

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..57] MSA 1.121996 View MSA. No confident structure predictions are available.
    2 View Details [58..481] PSI-BLAST 149.0 Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • NADH dehydrogenase activity
    		•  13.4136491947011 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  12.443012098477 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  12.1743193111446 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  11.5132141901667 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  10.8948060301507 bayes_pls_golite062009
  • oxidoreductase activity
    		•  6.75377893144873 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  3.21486196088149 bayes_pls_golite062009
  • 4 iron, 4 sulfur cluster binding
    		•  2.15499718507114 bayes_pls_golite062009
  • electron carrier activity
    		•  1.50427278540084 bayes_pls_golite062009
  • catalytic activity
    		•  1.46362311772849 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  1.25645944988955 bayes_pls_golite062009
  • metal cluster binding
    		•  1.25645944988955 bayes_pls_golite062009
  • binding
    		•  1.25265721111105 bayes_pls_golite062009
  • oxidoreductase activity, acting on hydrogen as donor
    		•  0.530794334701446 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  0.471058486160512 bayes_pls_golite062009
  • ferredoxin hydrogenase activity
    		•  0.281674499766589 bayes_pls_golite062009
  • oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
    		•  0.281674499766589 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle