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Protein Overview: Ercc1-PA

General Information:
Name(s) found: Ercc1-PA / FBpp0086578 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Ercc1 is referred to in FlyBase by the symbol Dmel\Ercc1 (CG10215, FBgn0028434). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10740470..10741453. It has the cytological map location 51C5. There is experimental evidence that it has the molecular function</span>: protein binding; protein heterodimerization activity. There is experimental evidence that it is involved in the biological process</span>: reciprocal meiotic recombination; nucleotide-excision repair. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 259 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA]
    protein complex [IDA]
    Biological Process: reciprocal meiotic recombination [IMP]
    nucleotide-excision repair, DNA incision, 5'-to lesion [ISS]
    nucleotide-excision repair [IMP]
    Molecular Function: protein binding [IPI]
    protein heterodimerization activity [IPI]
    damaged DNA binding [IEA]
    single-stranded DNA specific endodeoxyribonuclease activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDFDDDSFN DVLGAMEMPT AAKQPKVDAP AATAVNPAPS NSTEPSGSGR PAPGKPASNP  60
   61 HCVLVHSKQR GNPILKSILN VPLEFRDDIV PDYVVGRTSC VLYLSLKYHN LNPDYICQRL 120
  121 KALGKMYELR VLLVQVDTPE PNNALKSLTR ISLLADLTMM LAWNAEEAGK IIETYKQFEK 180
  181 RPPDLIMERV ESNPHQKLLA ALTNIKPVNK TDAAALLHTF GNLGNIINAS EERLSQVMGL 240
  241 GPRKAKKLYK TLQEPFLSK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..186] PSI-BLAST 30.69897 Crystal Structure of the Central Domain of Human ERCC1
    2 View Details [187..259] PSI-BLAST 17.522879 Crystal Structure of the Complex between the C-Terminal Domains of Human XPF and ERCC1


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle