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Protein Overview: Su(var)2-HP2-PB

General Information:
Name(s) found: Su(var)2-HP2-PB / FBpp0086631 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Su(var)2-HP2 is referred to in FlyBase by the symbol Dmel\Su(var)2-HP2 (CG12864, FBgn0026427). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10494659..10505550. It has the cytological map location 51B6. It is reported to have molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: mitotic chromosome condensation; gene silencing; heterochromatin formation; chromosome organization. 21 alleles are reported. The phenotypes of these alleles are annotated with: polytene chromosome; condensed chromosome. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1633 amino acids

    Gene Ontology:
    Cellular Component: condensed chromosome [IDA]
    polytene chromosome [TAS]
    heterochromatin [TAS]
    chromosome, centromeric region [TAS]
    nuclear heterochromatin [IDA]
    Biological Process: gene silencing [IMP]
    mitotic chromosome condensation [IMP]
    chromosome organization [IMP]
    heterochromatin formation [IMP]
    Molecular Function: DNA binding [IEA][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDIEYLDEY KDLVLPGIKS SAPTASSAGV PRQRRISSDS SNSSSIDADI FQKLFHGKYL  60
   61 DDELLKEGSG SKSQDRRRRP PSPSSSDESN DALEALFCGK SSQSKLSKRR ERYESFDSVD 120
  121 DLGEALMRPS HRLTVPKPST SQAGSKKSQD AAPHRSISNS SSSNIAMSSG QTYACPKNKK 180
  181 TNSVANKTAV SANGDKWASG KNKTVTIVKP QKTDLRPSRL EPKTDPLNLG DLYGDSDSDS 240
  241 SYEYESDFYG DQDSDEEDEP VIDISTDTSR TTSVAEAAKR KQRQDVEKSL TGKKEQVKPA 300
  301 RRRQLAEVEE RPSLKRSKTE SEAKSTVQGK YISIIGNETI MSSTTAPIRE TNREAASTSP 360
  361 SARKSAVQEA KHVETTKHII LGPPGKKLLH SDSPAAEVKK PMVQTLLSST LSLQKPSTLD 420
  421 DGSPLKIRKS LKKSIADENI DGDQSIFSSS SVLNKNTSVV APRKVNISVS LLQSKDTQVE 480
  481 TAASSSETPI LTKKEKLKTQ KSTKKPEGNK KTESKKKSLV QGPQMKTQKS EEAVSGPKIL 540
  541 NKYLKSETES SRKTVSTVTG RKQIGQLEVL KKPESRKSEE SLVEAISRKK QSQVQRLSKI 600
  601 DGRKSEGTSL PQPDVSKSET ALKAALPKET EFPVQDAEIE KMSKGRGHQN AVKNTKTEQP 660
  661 KSKPKTEVRS LQAEAATELM DSMDSQSDVS DIRATFPESQ GIFNVPGHMT RAISSNRSLA 720
  721 PTPTPMSDSQ RNASKERFTP VSDQKKPIRE SQTLSKRRAR GGRNQPLVSK RKAGEAEDGT 780
  781 AVINPKRPRE MDEEDHPQQN DHVQESAFAA FPVKITAASS VIPQVVRSTG NTVPQNISPR 840
  841 KLCVKINRRP YNKWLRSTQE RNEEQEGSRN VTSLPLLGET SETDSAAESM SESILQSQVQ 900
  901 SEPAIQPLPA SQPDSCTLQA SDLRIRESSA QLAPIAAYDS PAANDSSTSP ALDIAPESAQ 960
  961 TAKATLNTAL CPSTEKHLPD EPTLLESSKK VAEPQKLQTF QAKCLPVPIP EVKSEPEDIM1020
 1021 DEHSPNEPMP MVAAAPATPQ PHAITEDAGP DTIQVNTLGV STSSRPLELH SIPSASDPDG1080
 1081 NPNAIGQTKM YSFLYPKRYK QSYDDVGLDF CCPNLDGPMR AIDFTRLHSK AEVPVLEIPQ1140
 1141 FLVITTKFIS KADKNMPSKV RAKLELLDKS KERDSSKLTP TATTPTADPT GPSSFSPAPA1200
 1201 SVGPATQPFP SIIQNLLSAP LPDPGLFNHP TTVDPSTSTP VVSGSSSSTT ISADLDSLSK1260
 1261 QLPRGTKLIK KSVQQVATNP SLAGTSMVIN ASPSFIQLPP ICPNDKQRVE LQARVQMFDL1320
 1321 VLQTLSRRAA NLSVAERQRT IEEIVRTSSL MAIDVDVGTK LLENYVHYLN KATSTMTPLT1380
 1381 PAQINSSLGA STSSTLSKSI ATSDIPQQGK KISADHAQQR SSLPATIPLY DGGRNTLGFP1440
 1441 YSCSKSTAGR KSSYVATSTP VKASTSQAAA AAALGNAQPR STLGIPKSVR EDASQFVNLN1500
 1501 TTVCMPAPRT NAKKKPGTSG PLKSMNSSPA VQKPALCKQQ TAPARTLSKS TVSSVARAKS1560
 1561 TGSLSAVLGE TPADEFVSPA GMSLSTTGNP NVFIINHAVQ SEESILPDSN SSVGHMETTV1620
 1621 IKGELDDSAE III

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..233] deduced N/A No confident structure predictions are available.
    2 View Details [234..340] deduced N/A No confident structure predictions are available.
    3 View Details [341..574] deduced N/A No confident structure predictions are available.
    4 View Details [575..691] deduced N/A No confident structure predictions are available.
    5 View Details [692..873] deduced N/A No confident structure predictions are available.
    6 View Details [874..1085] MSA 2.198995 View MSA. No confident structure predictions are available.
    7 View Details [1086..1286] deduced N/A No confident structure predictions are available.
    8 View Details [1287..1526] deduced N/A No confident structure predictions are available.
    9 View Details [1527..1633] MSA 2.164987 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle