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Protein Overview: Su(var)2-HP2-PA

General Information:
Name(s) found: Su(var)2-HP2-PA / FBpp0086630 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Su(var)2-HP2 is referred to in FlyBase by the symbol Dmel\Su(var)2-HP2 (CG12864, FBgn0026427). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:10494659..10505550. It has the cytological map location 51B6. It is reported to have molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: mitotic chromosome condensation; gene silencing; heterochromatin formation; chromosome organization. 21 alleles are reported. The phenotypes of these alleles are annotated with: polytene chromosome; condensed chromosome. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 3257 amino acids

    Gene Ontology:
    Cellular Component: condensed chromosome [IDA]
    polytene chromosome [TAS]
    heterochromatin [TAS]
    chromosome, centromeric region [TAS]
    nuclear heterochromatin [IDA]
    Biological Process: gene silencing [IMP]
    mitotic chromosome condensation [IMP]
    chromosome organization [IMP]
    heterochromatin formation [IMP]
    Molecular Function: DNA binding [IEA][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDIEYLDEY KDLVLPGIKS SAPTASSAGV PRQRRISSDS SNSSSIDADI FQKLFHGKYL  60
   61 DDELLKEGSG SKSQDRRRRP PSPSSSDESN DALEALFCGK SSQSKLSKRR ERYESFDSVD 120
  121 DLGEALMRPS HRLTVPKPST SQAGSKKSQD AAPHRSISNS SSSNIAMSSG QTYACPKNKK 180
  181 TNSVANKTAV SANGDKWASG KNKTVTIVKP QKTDLRPSRL EPKTDPLNLG DLYGDSDSDS 240
  241 SYEYESDFYG DQDSDEEDEP VIDISTDTSR TTSVADTVTP VVSDDEGQEP QSELNQRHAN 300
  301 DQESFLSSTY ERLQSYLSNL SSAEPPPIYK KQNSARKSRS NEKKPSSSQQ VKHANEQSAA 360
  361 SDKEANKKER DLEPPEASSS AKSSASKASG SRKLYDVANN ATLEAVERMS LDLAEQIMEI 420
  421 DVERSYEFEK RSASKSRSLS RSKIPADSST SQLGHVRKLT YSSERLDQPE PLGTQLRRSK 480
  481 SESLPKRGRP RGQKQRKNRG ATMEEKSANC RDGEGEPVKR KRGRPRKIIP KEEAKTAETE 540
  541 NTIESLNTNV PLSIDTSKEN PETETVNLEV PIKQDELVSD LDNAKELTGS TNLPQDDIEM 600
  601 ASNHQETDLK CAPDRVALDK SESTPKVEEE QLCKVDTPSD TALDESKVSE SAKNHIELED 660
  661 KDKDKEETQK ESPNGNSKET NENSVIVTNE VELPAKKAEA KAEAGNIVEE SDSQLAEDFK 720
  721 LAEEILAAEV GKGVEANEVS VTSVQGEQNP VIEIVKELEQ ETISEVVPAQ NDQSSVEDQT 780
  781 LADKENPVEK PSPVKAPSSS KDEPPAEENL PAPDQDPIEQ QKTPVAKNQQ HDKEHNEAPK 840
  841 AESLSVSDIP SSSVTPSKKR NHSSPANTPK KSKEIEALQS SVPRRALRSD KATPQNLRES 900
  901 RSKRTLKTEL TLLMDDTMRR SSPRLGRSPA ESHSSHERSP MEKKVTVSKL AKDLITIDKE 960
  961 KEIELKSLPD ASETKDVKIT KTTTASDTSI LTDENPSSSK TEMKKLKGKP LKAKKMSRTS1020
 1021 ETEVKKAIAD SNEDIPSIFS IKCVEEHLTS SESEQKDEKE ELLCPKPQID CTNTDLEQST1080
 1081 AIETDTEQVE EKRSNRRKSR RIRNEKFKTE TDTLSDHLDA KKAENASLEI SMRPKCTLET1140
 1141 QQSDPVTAKN KRNSGRLSRK EKSVINAAKS EKDKSPSAIS QSTERKQLLN ENPSKKDKKT1200
 1201 EQSGNKKEAV VGPLDKTETS SSTNIIDKKS NESFDSAMQP SDRLNQKESA FTKLSSISSP1260
 1261 KKIMKDQDKD LDALSKGGDS NPTIRDTGED SRQTDKKHQE NDTKHEEEDS SKLKANIDET1320
 1321 KSSSEKDAEP ISKDSSQDSA KPRLSKPKSR NKRKKNEKKP NDSIAESDIE GGFQVNTETV1380
 1381 QATCSTPSES NKKDMVKSDE TNEEPNLSET EIGRIRKRGQ AFHIENPKDD LHITPQNENQ1440
 1441 SIAGVNFEKQ VPLPESVESD TPIMKIPTKT YLMCTKNKTS LLSASEDPDI VLEPQKLITT1500
 1501 SKGDSNPDLD NANNLETSST QDPKEHEFSD QTFTDNSDII PSCTKKSQIV FPTTPTKSSD1560
 1561 QTKNSFITPN RSPKSKRNVS KEAKRLDNSF EESQNAASES SASKVQKELR TPTASCRKLR1620
 1621 VLIKRTPTSS LPTNSRKSIF KKTPAKSKRL TKILESMEKT PSREPSVSLG EVNPDSDPVA1680
 1681 AESVAVLHES DRDLESNEIP NEEVFEDTEE ASAEDTDNKL KKKEDDHELE VNDICAASKN1740
 1741 PITDDSTKDA SSNKSTDSDV LQETKDELSN SLINATQGED TPIKELTEEE VPNNKTVEDE1800
 1801 SKKQEILKDL EPDNAALEED TASTAKAAEE MDLYIKEKSN VKSVLAEPET DVTDDEELAQ1860
 1861 SPIPNSSETT SVTDDPEPST SSVVKRSLRK READSSQPDE AAKRKQRQDV EKSLTGKKEQ1920
 1921 VKPARRRQLA EVEERPSLKR SKTESEAKST VQGKYISIIG NETIMSSTTA PIRETNREAA1980
 1981 STSPSARKSA VQEAKHVETT KHIILGPPGK KLLHSDSPAA EVKKPMVQTL LSSTLSLQKP2040
 2041 STLDDGSPLK IRKSLKKSIA DENIDGDQSI FSSSSVLNKN TSVVAPRKVN ISVSLLQSKD2100
 2101 TQVETAASSS ETPILTKKEK LKTQKSTKKP EGNKKTESKK KSLVQGPQMK TQKSEEAVSG2160
 2161 PKILNKYLKS ETESSRKTVS TVTGRKQIGQ LEVLKKPESR KSEESLVEAI SRKKQSQVQR2220
 2221 LSKIDGRKSE GTSLPQPDVS KSETALKAAL PKETEFPVQD AEIEKMSKGR GHQNAVKNTK2280
 2281 TEQPKSKPKT EVRSLQAEAA TELMDSMDSQ SDVSDIRATF PESQGIFNVP GHMTRAISSN2340
 2341 RSLAPTPTPM SDSQRNASKE RFTPVSDQKK PIRESQTLSK RRARGGRNQP LVSKRKAGEA2400
 2401 EDGTAVINPK RPREMDEEDH PQQNDHVQES AFAAFPVKIT AASSVIPQVV RSTGNTVPQN2460
 2461 ISPRKLCVKI NRRPYNKWLR STQERNEEQE GSRNVTSLPL LGETSETDSA AESMSESILQ2520
 2521 SQVQSEPAIQ PLPASQPDSC TLQASDLRIR ESSAQLAPIA AYDSPAANDS STSPALDIAP2580
 2581 ESAQTAKATL NTALCPSTEK HLPDEPTLLE SSKKVAEPQK LQTFQAKCLP VPIPEVKSEP2640
 2641 EDIMDEHSPN EPMPMVAAAP ATPQPHAITE DAGPDTIQVN TLGVSTSSRP LELHSIPSAS2700
 2701 DPDGNPNAIG QTKMYSFLYP KRYKQSYDDV GLDFCCPNLD GPMRAIDFTR LHSKAEVPVL2760
 2761 EIPQFLVITT KFISKADKNM PSKVRAKLEL LDKSKERDSS KLTPTATTPT ADPTGPSSFS2820
 2821 PAPASVGPAT QPFPSIIQNL LSAPLPDPGL FNHPTTVDPS TSTPVVSGSS SSTTISADLD2880
 2881 SLSKQLPRGT KLIKKSVQQV ATNPSLAGTS MVINASPSFI QLPPICPNDK QRVELQARVQ2940
 2941 MFDLVLQTLS RRAANLSVAE RQRTIEEIVR TSSLMAIDVD VGTKLLENYV HYLNKATSTM3000
 3001 TPLTPAQINS SLGASTSSTL SKSIATSDIP QQGKKISADH AQQRSSLPAT IPLYDGGRNT3060
 3061 LGFPYSCSKS TAGRKSSYVA TSTPVKASTS QAAAAAALGN AQPRSTLGIP KSVREDASQF3120
 3121 VNLNTTVCMP APRTNAKKKP GTSGPLKSMN SSPAVQKPAL CKQQTAPART LSKSTVSSVA3180
 3181 RAKSTGSLSA VLGETPADEF VSPAGMSLST TGNPNVFIIN HAVQSEESIL PDSNSSVGHM3240
 3241 ETTVIKGELD DSAEIII

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

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