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Protein Overview: Pimet-PA

General Information:
Name(s) found: Pimet-PA / FBpp0087092 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene piRNA methyltransferase is referred to in FlyBase by the symbol Dmel\Pimet (CG12367, FBgn0033686). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8033231..8040259. It has the cytological map location 48E2-48E3. There is experimental evidence that it has the molecular function</span>: O-methyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: posttranscriptional gene silencing by RNA; RNA methylation. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 391 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: RNA methylation [IDA][IMP]
    posttranscriptional gene silencing by RNA [IMP]
    Molecular Function: O-methyltransferase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFSHKFICGS LTKMTETGIT FDPPVYEQRY CATIQILEDA RWKDQIKKVV EFGCAEMRFF  60
   61 QLMRRIETIE HIGLVDIDKS LLMRNLTSVN PLVSDYIRSR ASPLKVQILQ GNVADSSEEL 120
  121 RDTDAVIAIE LIEHVYDDVL AKIPVNIFGF MQPKLVVFST PNSDFNVIFT RFNPLLPNGF 180
  181 RHEDHKFEWS RDEFKNWCLG IVEKYPNYMF SLTGVGNPPK EYESVGPVSQ IAIFVRKDML 240
  241 EMQLVNPLVS KPNIDKESIP YKLIHTVEYP FYVDTRTEKE KLWTEVQIEL QRFKRQFESS 300
  301 EIEEGTYQDT CNMPIAFLLD RLEHVGATKE RIEELLLENN LTVENECVLI VSSDQESEWS 360
  361 DPYKFSDRSS QDDALVDQEQ EEERWDQGPE S

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..275] PSI-BLAST 25.69897 Crystal structure of hypothetical protein (BH2331) from Bacillus halodurans at 1.95 A resolution
    2 View Details [276..391] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • methyltransferase activity
    		•  4.64500705012502 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.57389022626587 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.74830027382001 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.6174490060285 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  3.00112136063228 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  2.80578045927127 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  2.74535979387581 bayes_pls_golite062009
  • transferase activity
    		•  2.42370637689376 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  1.8182614465692 bayes_pls_golite062009
  • catalytic activity
    		•  1.62377578202456 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.42140847541194 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  1.40233857644962 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  1.40233857644962 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  1.32437128142157 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.88654745691593 bayes_pls_golite062009
  • rRNA (uridine) methyltransferase activity
    		•  0.75904932606473 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  0.72946673557525 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  0.67380437956274 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  0.62885479399246 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  0.355464145533041 bayes_pls_golite062009
  • rRNA (cytosine) methyltransferase activity
    		•  0.346042596102079 bayes_pls_golite062009
  • O-methyltransferase activity
    		•  0.32686871890222 bayes_pls_golite062009
  • binding
    		•  0.207713650201315 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle