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Protein Overview: Syx6-PE

General Information:
Name(s) found: Syx6-PE / FBpp0087203 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Syntaxin 6 is referred to in FlyBase by the symbol Dmel\Syx6 (CG7736, FBgn0037084). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:7107046..7109987. It has the cytological map location 47D7-47E1. Based on sequence similarity, it is predicted to have molecular function</span>: SNAP receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: synaptic vesicle docking during exocytosis. 4 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 339 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    plasma membrane [ISS][NAS]
    Biological Process: synaptic vesicle docking during exocytosis [ISS]
    vesicle-mediated transport [NAS]
    neurotransmitter secretion [NAS]
    Golgi vesicle transport [IEA]
    Molecular Function: protein binding [IEA]
    SNAP receptor activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATCTAGGKC YLTYISVFSF ISLPFPNSEV FKALNKTRGL YLRWRELGEN GGTEAEWTTT  60
   61 ELRNSLRSIE WDLEDLEDTI SIVEKNPSKF RIDNRELSSR RHFIDNTRDE VKQMKDKMSL 120
  121 NRSRDRDITA HQPLLDNDRH SPNHNHSIAI PNSNSNSNEY HQHPHNDRTY LVECPNGNSL 180
  181 INSGSQVANT IAGTMSAAAA AASRHSGTKY SKLENALDSP SHYGQTHHGG MDSPSHRYVG 240
  241 ETVSIQQRMI QGQDEQLDMI SDSIGTLKTV SRQIGVELDE QAVMLDDFGN EFDTTESKLD 300
  301 TTMKKVAKVL HMNNDKRQWA AILILSGLLL FVIILFIIL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..123] PSI-BLAST 7.30103 Syntaxin 6, SNAP-25 homolog
    2 View Details [124..339] FFAS03 2.51 Syntaxin 1A N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • SNAP receptor activity
    		•  3.50393203740159 bayes_pls_golite062009
  • phosphatidic acid binding
    		•  2.19104724611902 bayes_pls_golite062009
  • binding
    		•  2.13344290488739 bayes_pls_golite062009
  • SNARE binding
    		•  1.85060343142976 bayes_pls_golite062009
  • transporter activity
    		•  1.74189664015129 bayes_pls_golite062009
  • protein binding
    		•  1.51700626946713 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.2360389745429 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.13101548288086 bayes_pls_golite062009
  • protein transporter activity
    		•  0.81087535212264 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.398018181744571 bayes_pls_golite062009
  • extracellular ligand-gated ion channel activity
    		•  0.27873535382283 bayes_pls_golite062009
  • excitatory extracellular ligand-gated ion channel activity
    		•  0.27873535382283 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.0981818568206971 bayes_pls_golite062009
  • phospholipid binding
    		•  0.0172309833091902 bayes_pls_golite062009
    2
    Term Confidence Notes
  • SNAP receptor activity
    		•  2.87584659156593 bayes_pls_golite062009
  • binding
    		•  2.05804828912104 bayes_pls_golite062009
  • transporter activity
    		•  1.70608335538771 bayes_pls_golite062009
  • phosphatidic acid binding
    		•  1.63603523283739 bayes_pls_golite062009
  • SNARE binding
    		•  1.52310428500298 bayes_pls_golite062009
  • protein binding
    		•  1.40343943424791 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.17569067269837 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.13402377922348 bayes_pls_golite062009
  • protein transporter activity
    		•  0.593122950767464 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.396657939634767 bayes_pls_golite062009
  • extracellular ligand-gated ion channel activity
    		•  0.151199426202699 bayes_pls_golite062009
  • excitatory extracellular ligand-gated ion channel activity
    		•  0.151199426202699 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.0934422877951697 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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