Protein Overview: Syx6-PE

General Information:
Name(s) found:	Syx6-PE / FBpp0087203 [FlyBase]
Description(s) found: Found 22 descriptions. SHOW ALL	The gene Syntaxin 6 is referred to in FlyBase by the symbol Dmel\Syx6 (CG7736, FBgn0037084). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:7107046..7109987. It has the cytological map location 47D7-47E1. Based on sequence similarity, it is predicted to have molecular function</span>: SNAP receptor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: synaptic vesicle docking during exocytosis. 4 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	339 amino acids
Gene Ontology:
Cellular Component:	membrane [IEA] plasma membrane [ISS][NAS]
Biological Process:	synaptic vesicle docking during exocytosis [ISS] vesicle-mediated transport [NAS] neurotransmitter secretion [NAS] Golgi vesicle transport [IEA]
Molecular Function:	protein binding [IEA] SNAP receptor activity [ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATCTAGGKC YLTYISVFSF ISLPFPNSEV FKALNKTRGL YLRWRELGEN GGTEAEWTTT  60
   61 ELRNSLRSIE WDLEDLEDTI SIVEKNPSKF RIDNRELSSR RHFIDNTRDE VKQMKDKMSL 120
  121 NRSRDRDITA HQPLLDNDRH SPNHNHSIAI PNSNSNSNEY HQHPHNDRTY LVECPNGNSL 180
  181 INSGSQVANT IAGTMSAAAA AASRHSGTKY SKLENALDSP SHYGQTHHGG MDSPSHRYVG 240
  241 ETVSIQQRMI QGQDEQLDMI SDSIGTLKTV SRQIGVELDE QAVMLDDFGN EFDTTESKLD 300
  301 TTMKKVAKVL HMNNDKRQWA AILILSGLLL FVIILFIIL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..123]	PSI-BLAST	7.30103	Syntaxin 6, SNAP-25 homolog
2	View Details	[124..339]	FFAS03	2.51	Syntaxin 1A N-terminal domain

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
SNAP receptor activity	3.50393203740159	bayes_pls_golite062009
phosphatidic acid binding	2.19104724611902	bayes_pls_golite062009
binding	2.13344290488739	bayes_pls_golite062009
SNARE binding	1.85060343142976	bayes_pls_golite062009
transporter activity	1.74189664015129	bayes_pls_golite062009
protein binding	1.51700626946713	bayes_pls_golite062009
substrate-specific transporter activity	1.2360389745429	bayes_pls_golite062009
transmembrane transporter activity	1.13101548288086	bayes_pls_golite062009
protein transporter activity	0.81087535212264	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.398018181744571	bayes_pls_golite062009
extracellular ligand-gated ion channel activity	0.27873535382283	bayes_pls_golite062009
excitatory extracellular ligand-gated ion channel activity	0.27873535382283	bayes_pls_golite062009
ion transmembrane transporter activity	0.0981818568206971	bayes_pls_golite062009
phospholipid binding	0.0172309833091902	bayes_pls_golite062009

2

Term	Confidence	Notes
SNAP receptor activity	2.87584659156593	bayes_pls_golite062009
binding	2.05804828912104	bayes_pls_golite062009
transporter activity	1.70608335538771	bayes_pls_golite062009
phosphatidic acid binding	1.63603523283739	bayes_pls_golite062009
SNARE binding	1.52310428500298	bayes_pls_golite062009
protein binding	1.40343943424791	bayes_pls_golite062009
substrate-specific transporter activity	1.17569067269837	bayes_pls_golite062009
transmembrane transporter activity	1.13402377922348	bayes_pls_golite062009
protein transporter activity	0.593122950767464	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.396657939634767	bayes_pls_golite062009
extracellular ligand-gated ion channel activity	0.151199426202699	bayes_pls_golite062009
excitatory extracellular ligand-gated ion channel activity	0.151199426202699	bayes_pls_golite062009
ion transmembrane transporter activity	0.0934422877951697	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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