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Protein Overview: FBpp0297719, Pdk-PA

General Information:
Name(s) found: FBpp0297719 [FlyBase]
Pdk-PA / FBpp0087592 [FlyBase]
Description(s) found:
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  • gi|73620982|sp|P91622.2|PDK_DROME RecName: Full=[Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial; Short=Pyruvate dehydrogenase kinase; Short=DmPDK; Flags: Precursor [NCBI NR]
  • gi|7303893|gb|AAF58938.1| pyruvate dehydrogenase kinase, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|18447293|gb|AAL68223.1| LD23669p [Drosophila melanogaster] [NCBI NR]
  • gi|17137298|ref|NP_477215.1| pyruvate dehydrogenase kinase, isoform A [Drosophila melanogaster] [NCBI NR]
  • [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial OS=Drosophila melanogaster GN=Pdk PE=2 SV=2 [Swiss-Prot]
  • type=protein; loc=2R:join(5314755..5314878,5319476..5319683,5319740..5319930,5319995..5320569,5320635..5320778); ID=FBpp0297719; name=Pdk-PC; parent=FBgn0017558,FBtr0306807; dbxref=REFSEQ:NP_001246224,GB_protein:AFH07979,FlyBase:FBpp0297719,FlyBase_Annotation_IDs:CG8808-PC; MD5=71f7b22de3e23bbf493fad219580f3f7; length=413; release=r5.56; species=Dmel; [FlyBase]
  • The gene Pyruvate dehydrogenase kinase is referred to in FlyBase by the symbol Dmel\Pdk (CG8808, FBgn0017558). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:5313947..5321930. It has the cytological map location 45D5-45D7. Based on sequence similarity, it is predicted to have molecular function</span>: pyruvate dehydrogenase (acetyl-transferring) kinase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: pyruvate metabolic process. 12 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG8808-PA translation from_gene[CG8808 Pdk FBgn0017558] seq_release:3 mol_weight=46627 cds_boundaries:(2R:4,487,882..4,493,902[+]) aa_length:413 transcript_info:[CG8808-RA seq_release:3] gene_info:[gene symbol:Pdk FBgn0017558 gene_boundaries:(2R:4,487 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9V580) PDK protein (LD23669p) [DrosMelano7227.FASTAC.txt]
  • (AE003833) Pdk gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG8808-PA [Drosophila melanogaster]gi|18447293|gb|AAL68223.1| LD23669p [Drosophila melanogaster]gi|17137298|ref|NP_477215.1| CG8808-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:join(5314755..5314878,5319476..5319683,5319740..5319930,5319995..5320569,5320635..5320778); ID=FBpp0087592; name=Pdk-PA; parent=FBgn0017558,FBtr0088508; dbxref=FlyBase:FBpp0087592,FlyBase_Annotation_IDs:CG8808-PA,GB_protein:AAF58938.1 [fly-100309-contam.fasta]
  • CG8808-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Pyruvate dehydrogenase kinase CG8808-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • [Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial precursor (Pyruvate dehydrogenase kinase) (DmPDK) [nr-271106-contam.fasta]
  • LD23669p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:join(5314755..5314878,5319476..5319683,5319740..5319930,5319995..5320569,5320635..5320778); ID=FBpp0087592; name=Pdk-PA; parent=FBgn0017558,FBtr0088508; dbxref=FlyBase:FBpp0087592,FlyBase_Annotation_IDs:CG8808-PA,GB_protein:AAF58938.1,REFSEQ:NP_477215,GB_protein:AAF58938; MD5=71f7b22de3e23bbf493fad219580f3f7; length=413; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:join(5314755..5314878,5319476..5319683,5319740..5319930,5319995..5320569,5320635..5320778); ID=FBpp0087592; name=Pdk-PA; parent=FBgn0017558,FBtr0088508; dbxref=FlyBase:FBpp0087592,FlyBase_Annotation_IDs:CG8808-PA,GB_protein:AAF58938.1,REFSEQ:NP_477215,GB_protein:AAF58938; MD5=71f7b22de3e23bbf493fad219580f3f7; length=413; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • [Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial OS=Drosophila melanogaster GN=Pdk PE=2 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:join(5314755..5314878,5319476..5319683,5319740..5319930,5319995..5320569,5320635..5320778); ID=FBpp0087592; name=Pdk-PA; parent=FBgn0017558,FBtr0088508; dbxref=FlyBase:FBpp0087592,FlyBase_Annotation_IDs:CG8808-PA,GB_protein:AAF58938.1,REFSEQ:NP_477215,GB_protein:AAF58938,FlyMine:FBpp0087592,modMine:FBpp0087592; MD5=71f7b22de3e23bbf493fad219580f3f7; length=413; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:join(5314755..5314878,5319476..5319683,5319740..5319930,5319995..5320569,5320635..5320778); ID=FBpp0297719; name=Pdk-PC; parent=FBgn0017558,FBtr0306807; dbxref=REFSEQ:NP_001246224,GB_protein:AFH07979,FlyBase:FBpp0297719,FlyBase_Annotation_IDs:CG8808-PC; MD5=71f7b22de3e23bbf493fad219580f3f7; length=413; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:join(9427250..9427373,9431971..9432178,9432235..9432425,9432490..9433064,9433130..9433273); ID=FBpp0087592; name=Pdk-PA; parent=FBgn0017558,FBtr0088508; dbxref=FlyBase:FBpp0087592,FlyBase_Annotation_IDs:CG8808-PA,GB_protein:AAF58938.1,REFSEQ:NP_477215,GB_protein:AAF58938,FlyMine:FBpp0087592,modMine:FBpp0087592; MD5=71f7b22de3e23bbf493fad219580f3f7; length=413; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(9427250..9427373,9431971..9432178,9432235..9432425,9432490..9433064,9433130..9433273); ID=FBpp0297719; name=Pdk-PC; parent=FBgn0017558,FBtr0306807; dbxref=REFSEQ:NP_001246224,GB_protein:AFH07979,FlyBase:FBpp0297719,FlyBase_Annotation_IDs:CG8808-PC; MD5=71f7b22de3e23bbf493fad219580f3f7; length=413; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:join(9427250..9427373,9431971..9432178,9432235..9432425,9432490..9433064,9433130..9433273); ID=FBpp0087592; name=Pdk-PA; parent=FBgn0017558,FBtr0088508; dbxref=FlyBase:FBpp0087592,FlyBase_Annotation_IDs:CG8808-PA,GB_protein:AAF58938.1,REFSEQ:NP_477215,GB_protein:AAF58938,FlyMine:FBpp0087592,modMine:FBpp0087592; MD5=71f7b22de3e23bbf493fad219580f3f7; length=413; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=2R:join(9427250..9427373,9431971..9432178,9432235..9432425,9432490..9433064,9433130..9433273); ID=FBpp0297719; name=Pdk-PC; parent=FBgn0017558,FBtr0306807; dbxref=REFSEQ:NP_001246224,GB_protein:AFH07979,FlyBase:FBpp0297719,FlyBase_Annotation_IDs:CG8808-PC; MD5=71f7b22de3e23bbf493fad219580f3f7; length=413; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of P91622, Pyruvate dehydrogenase kinase, isoform C OS=Drosophila melanogaster GN=Pdk PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0087592 type=protein; loc=2R:join(9427250..9427373,9431971..9432178,9432235..9432425,9432490..9433064,9433130..9433273); ID=FBpp0087592; name=Pdk-PA; parent=FBgn0017558,FBtr0088508; dbxref=FlyBase:FBpp0087592,FlyBase_Annotation_IDs:CG8808-PA,GB_protein:AAF58938.1,REFSEQ:NP_477215,GB_protein:AAF58938,FlyMine:FBpp0087592,modMine:FBpp0087592; MD5=71f7b22de3e23bbf493fad219580f3f7; length=413; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0297719 type=protein; loc=2R:join(9427250..9427373,9431971..9432178,9432235..9432425,9432490..9433064,9433130..9433273); ID=FBpp0297719; name=Pdk-PC; parent=FBgn0017558,FBtr0306807; dbxref=REFSEQ:NP_001246224,GB_protein:AFH07979,FlyBase:FBpp0297719,FlyBase_Annotation_IDs:CG8808-PC; MD5=71f7b22de3e23bbf493fad219580f3f7; length=413; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:join(9427250..9427373,9431971..9432178,9432235..9432425,9432490..9433064,9433130..9433273); ID=FBpp0087592; name=Pdk-PA; parent=FBgn0017558,FBtr0088508; dbxref=FlyBase:FBpp0087592,FlyBase_Annotation_IDs:CG8808-PA,GB_protein:AAF58938.1,REFSEQ:NP_477215,GB_protein:AAF58938,UniProt/Swiss-Prot:P91622,FlyMine:FBpp0087592,modMine:FBpp0087592; MD5=71f7b22de3e23bbf493fad219580f3f7; length=413; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=2R:join(9427250..9427373,9431971..9432178,9432235..9432425,9432490..9433064,9433130..9433273); ID=FBpp0297719; name=Pdk-PC; parent=FBgn0017558,FBtr0306807; dbxref=REFSEQ:NP_001246224,GB_protein:AFH07979,FlyBase:FBpp0297719,FlyBase_Annotation_IDs:CG8808-PC,UniProt/Swiss-Prot:P91622; MD5=71f7b22de3e23bbf493fad219580f3f7; length=413; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 413 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [ISS][NAS]
    Biological Process: signal transduction [IEA]
    pyruvate metabolic process [ISS]
    peptidyl-histidine phosphorylation [IEA]
    Molecular Function: two-component sensor activity [IEA]
    ATP binding [IEA]
    pyruvate dehydrogenase (acetyl-transferring) kinase activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLFPVRFSA ASSSMASLAK MLDFYSGFNP SPLSIKQFMD FGQNACEKKS YIFLRKELPV  60
   61 RLANIMKEIA LLPDNLLHTR SVSEVSSWYV KSFEDVLVYE KAEPTHDNLQ KFVADLDLIR 120
  121 NRHNDVVQTM AQGVIEMKEN EGGQVDAPTE SSIQYFLDRL YMSRISIRML INQHTLLFGG 180
  181 NPHAGGRHIG CLDPACDLSD VVRDAYENAR FLCDQYYLTS PALEIQQHSS EPGDNLPIRT 240
  241 VYVPSHLYYM LFELFKNSMR AVVEHHGHDN NDTLPPLKVA ICKGKEDICV KISDQGGGIP 300
  301 RSQTDQLFKY MYSTAPQPSK SDLHTVPLAG YGYGLPISRL YARYFHGDIV LLSCEGFGTD 360
  361 AIIYLKALSD EANELLPIFN KTSSKFYRAT VPTGDWSNQV KYAKKKKTSA VNQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..413] PSI-BLAST 53.69897 Pyruvate dehydrogenase kinase


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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