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Protein Overview: Kdm4A-PA

General Information:
Name(s) found: Kdm4A-PA / FBpp0087961 [FlyBase]
Description(s) found:
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  • gi|74867006|sp|Q9V333.1|KDM4A_DROME RecName: Full=Probable lysine-specific demethylase 4A; AltName: Full=Probable JmjC domain-containing histone demethylation protein 3A [NCBI NR]
  • gi|7304135|gb|AAF59172.1| CG15835 [Drosophila melanogaster] [NCBI NR]
  • gi|19921768|ref|NP_610331.1| CG15835 [Drosophila melanogaster] [NCBI NR]
  • gi|16198125|gb|AAL13865.1| LD33386p [Drosophila melanogaster] [NCBI NR]
  • Probable lysine-specific demethylase 4A OS=Drosophila melanogaster GN=Kdm4A PE=1 SV=1 [Swiss-Prot]
  • Probable JmjC domain-containing histone demethylation protein 3A OS=Drosophila melanogaster GN=CG15835 PE=1 SV=1 [Swiss-Prot]
  • The gene Histone demethylase 4A is referred to in FlyBase by the symbol Dmel\Kdm4A (CG15835, FBgn0033233). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3810274..3812488. It has the cytological map location 43F2. There is experimental evidence that it has the molecular function</span>: histone demethylase activity (H3-K36 specific); histone demethylase activity (H3-K9 specific). There is experimental evidence that it is involved in the biological process</span>: histone H3-K36 demethylation; histone H3-K9 demethylation. 8 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG15835-PA translation from_gene[CG15835 CG15835 FBgn0033233] seq_release:3 mol_weight=56991 cds_boundaries:(2R:2,984,141..2,985,817[-]) aa_length:495 transcript_info:[CG15835-RA seq_release:3] gene_info:[gene symbol:CG15835 FBgn0033233 gene_boundarie [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9V333) CG15835 protein (LD33386P) [DrosMelano7227.FASTAC.txt]
  • (AE003839) CG15835 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG15835-PA [Drosophila melanogaster]gi|16198125|gb|AAL13865.1| LD33386p [Drosophila melanogaster]gi|19921768|ref|NP_610331.1| CG15835-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(3810742..3811117,3811174..3812037,3812103..3812194,3812266..3812421); ID=FBpp0087961; name=CG15835-PA; parent=FBgn0033233,FBtr0088886; dbxref=FlyBase:FBpp0087961,FlyBase_Annotation_IDs:CG15835-PA,GB_protein:AAF59172.1,REFSE [fly-100309-contam.fasta]
  • Probable JmjC domain-containing histone demethylation protein 3A [nr-271106-contam.fasta]
  • LD33386p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG15835-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(3810742..3811117,3811174..3812037,3812103..3812194,3812266..3812421); ID=FBpp0087961; name=CG15835-PA; parent=FBgn0033233,FBtr0088886; dbxref=FlyBase:FBpp0087961,FlyBase_Annotation_IDs:CG15835-PA,GB_protein:AAF59172.1,REFSEQ:NP_610331,GB_protein:AAF59172; MD5=877a0f4dda4811961ee8d77cc0fa600a; length=495; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(3810742..3811117,3811174..3812037,3812103..3812194,3812266..3812421); ID=FBpp0087961; name=Kdm4A-PA; parent=FBgn0033233,FBtr0088886; dbxref=FlyBase:FBpp0087961,FlyBase_Annotation_IDs:CG15835-PA,GB_protein:AAF59172.1,REFSEQ:NP_610331,GB_protein:AAF59172; MD5=877a0f4dda4811961ee8d77cc0fa600a; length=495; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=2R:complement(3810742..3811117,3811174..3812037,3812103..3812194,3812266..3812421); ID=FBpp0087961; name=Kdm4A-PA; parent=FBgn0033233,FBtr0088886; dbxref=FlyBase:FBpp0087961,FlyBase_Annotation_IDs:CG15835-PA,GB_protein:AAF59172.1,REFSEQ:NP_610331,GB_protein:AAF59172,FlyMine:FBpp0087961,modMine:FBpp0087961; MD5=877a0f4dda4811961ee8d77cc0fa600a; length=495; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:complement(join(7924761..7924916,7924598..7924689,7923669..7924532,7923237..7923612)); ID=FBpp0087961; name=Kdm4A-PA; parent=FBgn0033233,FBtr0088886; dbxref=FlyBase:FBpp0087961,FlyBase_Annotation_IDs:CG15835-PA,GB_protein:AAF59172.1,REFSEQ:NP_610331,GB_protein:AAF59172,FlyMine:FBpp0087961,modMine:FBpp0087961; MD5=877a0f4dda4811961ee8d77cc0fa600a; length=495; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(7924761..7924916,7924598..7924689,7923669..7924532,7923237..7923612)); ID=FBpp0087961; name=Kdm4A-PA; parent=FBgn0033233,FBtr0088886; dbxref=FlyBase:FBpp0087961,FlyBase_Annotation_IDs:CG15835-PA,GB_protein:AAF59172.1,REFSEQ:NP_610331,GB_protein:AAF59172,FlyMine:FBpp0087961,modMine:FBpp0087961; MD5=877a0f4dda4811961ee8d77cc0fa600a; length=495; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0087961 type=protein; loc=2R:complement(join(7924761..7924916,7924598..7924689,7923669..7924532,7923237..7923612)); ID=FBpp0087961; name=Kdm4A-PA; parent=FBgn0033233,FBtr0088886; dbxref=FlyBase:FBpp0087961,FlyBase_Annotation_IDs:CG15835-PA,GB_protein:AAF59172.1,REFSEQ:NP_610331,GB_protein:AAF59172,FlyMine:FBpp0087961,modMine:FBpp0087961; MD5=877a0f4dda4811961ee8d77cc0fa600a; length=495; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(7924761..7924916,7924598..7924689,7923669..7924532,7923237..7923612)); ID=FBpp0087961; name=Kdm4A-PA; parent=FBgn0033233,FBtr0088886; dbxref=FlyBase:FBpp0087961,FlyBase_Annotation_IDs:CG15835-PA,GB_protein:AAF59172.1,REFSEQ:NP_610331,GB_protein:AAF59172,UniProt/Swiss-Prot:Q9V333,FlyMine:FBpp0087961,modMine:FBpp0087961; MD5=877a0f4dda4811961ee8d77cc0fa600a; length=495; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 495 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    Biological Process: histone H3-K36 demethylation [IMP]
    histone H3-K9 demethylation [IMP]
    histone demethylation [ISS]
    Molecular Function: histone demethylase activity (H3-K9 specific) [IMP]
    transcription repressor activity [ISS]
    histone demethylase activity (H3-K36 specific) [IDA][IMP][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTRSSFADE EQNKVPRIMT FRPSYEEFQN FSAYIEYIES RGAHLAGLAK IQPPAEWVPR  60
   61 KSGYDIDNIN MTIPAPICQV VTGAHGVYQQ INIQQRRQMT LRQFMEKANS ELHQTPRHFD 120
  121 YDDLERKYWK NITYISPLYA ADVKGSLSDE DLDVWNIGRL DTILNLVNTD YNIIIDGVNT 180
  181 AYLYFGMWKS SFAWHTEDMD LYSINYLHFG APKTWYAIPP AYGRRLEKLA NETFSENYQE 240
  241 CNAYLRHKMT MISPKVLRQH NIPYNKITQE AGEIMITFPF GYHAGFNHGF NGAESTNFAS 300
  301 KRWIEYGKRA SICRCRSDMV KISMETFVRR FQPERYDNWL KGQDMGCHPE EPGKICAAAP 360
  361 PTLNEYEKQE NLRAAKSEEE SPQKRGCSLA GNGCERNAES AEDVDDKASV SSYSSCRQLQ 420
  421 PVVKLRKLPT IASVPEPSSA PKRYDFNTEA VVRVKRLWNE LPCPDRGANL LTNGVVKNTK 480
  481 RMRFQTKVLT LDDED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..397] PSI-BLAST 102.0 No description for 2oq6A was found.
    2 View Details [398..495] MSA 2.170995 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle