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Protein Overview: Incenp-PA, FBpp0...

General Information:
Name(s) found: FBpp0307848 [FlyBase]
Incenp-PA / FBpp0088035 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • type=protein; loc=2R:join(3166234..3166302,3166366..3166546,3166612..3167671,3167735..3167831,3167976..3168642,3168799..3168992); ID=FBpp0307848; name=Incenp-PB; parent=FBgn0260991,FBtr0336908; dbxref=REFSEQ:NP_001260762,GB_protein:AGB93295,FlyBase:FBpp0307848,FlyBase_Annotation_IDs:CG12165-PB; MD5=6bf88463d368cdbb0a2252fe24b1e05c; length=755; release=r5.56; species=Dmel; [FlyBase]
  • The gene Inner centromere protein is referred to in FlyBase by the symbol Dmel\Incenp (CG12165, FBgn0260991). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:3165972..3169066. It has the cytological map location 43A2-43A3. There is experimental evidence that it has the molecular function</span>: protein binding; microtubule binding. There is experimental evidence that it is involved in the biological process</span>: protein localization; metaphase plate congression; male meiosis sister chromatid cohesion; meiotic chromosome condensation; spindle midzone assembly involved in meiosis; mitotic spindle organization; histone phosphorylation; spindle assembly involved in female meiosis. 8 alleles are reported. The phenotypes of these alleles are annotated with: eye; mitotic cell cycle; spindle; stage 5 embryo. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 755 amino acids

    Gene Ontology:
    Cellular Component: condensed chromosome [IDA]
    spindle midzone [IDA]
    midbody [IDA]
    chromosome [IDA]
    chromosome, centromeric region [IDA]
    Biological Process: spindle midzone assembly involved in meiosis [IMP]
    metaphase plate congression [IMP]
    meiotic chromosome condensation [IMP]
    male meiosis sister chromatid cohesion [IMP]
    mitotic spindle organization [IMP]
    protein localization [IMP]
    histone phosphorylation [IMP]
    cytokinesis [IMP]
    asymmetric cell division [IMP]
    spindle assembly involved in female meiosis [IMP]
    Molecular Function: protein binding [IPI]
    microtubule binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDILGVLGS LSDLRRELEV LRKAHFEELD HLFYGTGQPE AEAKPRDSAP AAKSQENSSV  60
   61 TPQQTKKRPK RLTSLAEDQN EPEAPDATAN NTSARQSTRV SNSQLLAIAE DEHNSTASLM 120
  121 PPPPVPVSAD TTLGSGRPQR AAKLKTEKLL KEPSLNRKMR RPSSEELVKV KVESEQRVSQ 180
  181 FNSFTSAQAL EENKLAEPEL EEPAAETAEQ QKPPEEASVT EDVNTTKTLR VKVKREKLST 240
  241 EAVPPLTNAV STANVTTVSS VTTEAARPDD TVASNTTTST EVSKKVRKKK KDVESHRPIK 300
  301 VERFSDLDKS SPVSSRTRKC SSDSRTVQER SIYKDALEDP PVAEQSVAAV APAAVNETVA 360
  361 ISNATLVLGP APTSDSPIGP AGDATFEVHS NDKKQPLSKQ DSLLTEDESV EEKLPTTKLL 420
  421 SSIKAIKLPT RTHELFNPLL QSPVKMRVEA FENAANAQNS MRPKRGKDLQ GTPGSNNTPK 480
  481 IGKLPAPTVG RFFTPTQTTS TLPLSSAQPK KGPASASKAT SLLKTATGTN LRSVNSTSTK 540
  541 TLSRENSGDD FRKGLHNLAE ERKKLREQKH QQAAQQREAK ERERAERMAK LAAERAKKQE 600
  601 ERKRIEERKR QELEELQRKM RQQEEAEALK KAKFKELEQQ KLQQLTGAKP KKMLPPPPKT 660
  661 KYTWEMLHED DSTDDEGKVT HKRPPAPTWS RSHVRGEAIA MQSHCPTDII DSFFSVAPTT 720
  721 PDLKQIFPNI DPSQLKRNSS VLWSTPPRYS ELPKY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..348] FFAS03 3.07 THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
    2 View Details [349..538] deduced N/A No confident structure predictions are available.
    3 View Details [539..755] MSA 2.297995 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle