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Protein Overview: Epac-PD, FBpp0302891

General Information:
Name(s) found: FBpp0302891 [FlyBase]
Epac-PD / FBpp0111548 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • type=protein; loc=2R:complement(2650152..2650279,2650339..2650688,2650972..2651105,2651326..2651496,2651556..2651809,2651880..2652241,2653041..2653202,2653440..2653616,2654556..2654700,2654920..2655065,2655627..2655819,2655874..2656015,2656084..2656170,2656431..2656528,2656813..2656849); ID=FBpp0302891; name=Epac-PG; parent=FBgn0085421,FBtr0329851; dbxref=FlyBase:FBpp0302891,FlyBase_Annotation_IDs:CG34392-PG,REFSEQ:NP_001260737,GB_protein:AGB93270; MD5=3dca9d40e39508fc007f77bef158ec98; length=861; release=r5.56; species=Dmel; [FlyBase]
  • The gene Epac is referred to in FlyBase by the symbol Dmel\Epac (CG34392, FBgn0085421). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2649417..2684421. It has the cytological map location 42D1. Based on sequence similarity, it is predicted to have molecular function</span>: cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity; Rap guanyl-nucleotide exchange factor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: regulation of protein amino acid phosphorylation; regulation of small GTPase mediated signal transduction. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 861 amino acids

    Gene Ontology:
    Cellular Component: cAMP-dependent protein kinase complex [IEA]
    Biological Process: regulation of small GTPase mediated signal transduction [IEA]
    regulation of protein amino acid phosphorylation [IEA]
    Molecular Function: cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity [ISS]
    Rap guanyl-nucleotide exchange factor activity [ISS]
    cAMP-dependent protein kinase regulator activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNDIFTNCKL KNGFGPSVQA TAAATSPTKR PLSPDHPNPA LPITETPSPA MNRMGWALRT  60
   61 LLVADNSSCL KDRKVSGKLI RKCAPGTELV DWLVNLSPIV HTRAQAAGMW QALLEEGVLA 120
  121 HVNKEQPFKD KCFLYRFRID EEGGTAAAGV PQAEDLGAAN EHIREALSAL FQRGPDATLR 180
  181 MILRKPSHER TSEELELVFE ELVHIAALSH LSTSIKRELS SIFVFEAHAQ AGTILFNQGD 240
  241 EGRSWYILLK GSVDVVIHGK GTVATLKTGD DFGKLALIND APRAATIVLK ENNCHLLRVD 300
  301 KEHFNRILRD VEANTLRLQE HGKDVLVLER VAKQRGQHSA FKYTVMSGTP AKMLEHLLET 360
  361 RLGQSVGGMD PFLDDFLLTH IVFMPVVQLV DELANYFHCD AHEDAQTPED REYIINFKKR 420
  421 VIQFMQKWVM AVRHAAFEEP SVCDFIEDLA AEVEADPDLN EETSIVHNVL TQMARYQEDR 480
  481 NQNAGQKWKL PPNGQPICLF SGNATPSKTV IRPDDDIIFR VYCADHTYCT LRFPMHTTAE 540
  541 LIKACAADKL QLNRGPEDLV LVEVKSNGER SVFKDNDVSI PTGLSLNGRL FVSVKDHLDA 600
  601 LTQLQEQECP TEGVDIDLEI LSTKELAYHI TLFEWDLFWA VHEYELLYHT FGRHHFGKIT 660
  661 ANLDVFLRRF NEVQYWIVTE LVSTPSLSKR VGLVRKFIKL AAYCKEYQNL NAFFAVVMGL 720
  721 SNMAVSRLQQ TWEKIPSKFR KIFQEFEALI DPSRNHRAYR VFVGKLQPPL IPFMPLLLKD 780
  781 MTFAHEGNKT SLDGLVNFEK MHMMAQTMRT IRFCRSRSLG LEPPSPKSEG EVRSYISSFR 840
  841 VIDNQRVLTA MSQKVEPTRK L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..861] PSI-BLAST 136.0 Structure of the cAMP responsive exchange factor Epac2 in its auto- inhibited state


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle