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Protein Overview: l(2)01289-PA

General Information:
Name(s) found: l(2)01289-PA / FBpp0085469 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene lethal (2) 01289 is referred to in FlyBase by the symbol Dmel\l(2)01289 (CG9432, FBgn0010482). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:2608606..2628149. It has the cytological map location 42C6-42C7. Based on sequence similarity, it is predicted to have molecular function</span>: protein disulfide isomerase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: cell redox homeostasis. 22 alleles are reported. No phenotypic data is available. It has 7 annotated transcripts and 7 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 857 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [ISS]
    Biological Process: cell redox homeostasis [IEA]
    Molecular Function: protein disulfide isomerase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTFTRLKTLS LLVCALLALS FPGHVSGAGN NNNKKGSQPV APPEPEAVIE EVNAKQLEKL  60
   61 LADKDYVAVF WYARSCVTCD KVLAELEKID DDTDSFGVDF VKINDKRLAK QYGIKNFPAL 120
  121 TYFREKEPII YDGDLMDEEG VLDFLTSLEA MDLPDRIEEV NAKILQKIIE DTDFVAVLFY 180
  181 DKDQKKSQKI LAELENIDDE CDQNDIAFVK IDDDKEAKEW GIDEIPSIVL FERGIPHIYE 240
  241 GDLMKEDELL GWLVHQKRYS EIPEVTDEMK DKLVENTEHL AVIFYDKDDK QDMRILNELE 300
  301 NIDDELEKEG IVIVRIDNAA EAKEYGLDHL PALIYFENKI PALYEGDLMN EDEVLEWLLV 360
  361 QKKTATIEEV TDEILVTLIN EHEYVVVFFT GPCEPGETCE HTLNALESID DELDEAGIIF 420
  421 VTTEDTGIAK KYNVKTYPRL VFFRNRDPLH FTGDLDDEDE VLAWITDDET LEIPGKIEEV 480
  481 NVKMLDKILA ENDHVVVFFY AEGDKKAQKI LNELENIDDE CEEKDIDFVK TSDDDIDKEY 540
  541 DLPGLPALAF YRHKFRTIYT GDLMKEEEIL EWVIDLHEST ADVIESVDRK TLQVLINDVE 600
  601 HLAVFFYDDE CESCSDILEE LENIDDDTDK HGIQFVKSND VKLAHEIGIF AFPALVYYET 660
  661 GVPIMYDGNL KNENRVLQWL VNQKNDECFY VGLGHDGHSA KRGNNFVPND YKPFQCCPTK 720
  721 LEKSTKVPKM TAQRIGHSEG DQGKRPSGGN FQFANQASSK SSTKPAAIKK QAKPSKDTDD 780
  781 DDEDDEDKPL VKVSYANKRS GGSNKPQAGK KPVGKGQDND DQSQEVEKVS KQKSAKKSGK 840
  841 LNVKSGYLSV GVRQQFN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..468] PSI-BLAST 49.0 Crystal Structure of Yeast Protein Disulfide Isomerase
    2 View Details [469..686] PSI-BLAST 19.39794 CRYSTAL STRUCTURE OF CALSEQUESTRIN FROM RABBIT SKELETAL MUSCLE SARCOPLASMIC RETICULUM AT 2.4 A RESOLUTION
    3 View Details [687..857] PSI-BLAST 23.30103 No description for 2h8lA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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