Protein Overview: Top3alpha-PA

General Information:
Name(s) found:	Top3alpha-PA / FBpp0080787 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|51092196\|gb\|AAT94511.1\| LD04601p [Drosophila melanogaster] [NCBI NR] gi\|33860232\|sp\|Q9NG98.2\|TOP3A_DROME RecName: Full=DNA topoisomerase 3-alpha; AltName: Full=DNA topoisomerase III alpha [NCBI NR] gi\|24585251\|ref\|NP_523602.2\| topoisomerase 3alpha [Drosophila melanogaster] [NCBI NR] gi\|22946848\|gb\|AAF53813.2\| topoisomerase 3alpha [Drosophila melanogaster] [NCBI NR] (Q9NG98) DNA topoisomerase III alpha (EC 5.99.1.2) [Swiss-Prot] DNA topoisomerase 3-alpha OS=Drosophila melanogaster GN=Top3alpha PE=2 SV=2 [Swiss-Prot] The gene Topoisomerase 3Ă?Ă?Âą is referred to in FlyBase by the symbol Dmel\Top3Ă?Ă?Âą (CG10123, FBgn0040268). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:19498179..19502268. It has the cytological map location 37E4. There is experimental evidence that it has the molecular function</span>: DNA topoisomerase activity. There is experimental evidence that it is involved in the biological process</span>: double-strand break repair via homologous recombination. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG10123-PA translation from_gene[CG10123 Top3alpha FBgn0040268] seq_release:3 mol_weight=136138 cds_boundaries:(2L:19,476,321..19,480,246[+]) aa_length:1250 transcript_info:[CG10123-RA seq_release:3] gene_info:[gene symbol:Top3alpha FBgn0040268 gene_b [hmr_yeast5_DM3-1_pombe.fasta] CG10123-PA [Drosophila melanogaster]gi\|51092196\|gb\|AAT94511.1\| LD04601p [Drosophila melanogaster]gi\|24585251\|ref\|NP_523602.2\| CG10123-PA [Drosophila melanogaster]gi\|33860232\|sp\|Q9NG98\|TP3A_DROME DNA topoisomerase III alpha [nrdb_11152004_Chlamydomonas] type=protein; loc=2L:join(19498238..19498393,19498460..19499093,19499146..19499607,19499666..19502166); ID=FBpp0080787; name=Top3alpha-PA; parent=FBgn0040268,FBtr0081246; dbxref=FlyBase:FBpp0080787,FlyBase_Annotation_IDs:CG10123-PA,GB_protein:AAF53813.2,R [fly-100309-contam.fasta] LD04601p [Drosophila melanogaster] [nr-271106-contam.fasta] CG10123-PA [Drosophila melanogaster] [nr-271106-contam.fasta] DNA topoisomerase 3-alpha (DNA topoisomerase III alpha) [nr-271106-contam.fasta] Topoisomerase 3alpha CG10123-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2L:join(19498238..19498393,19498460..19499093,19499146..19499607,19499666..19502166); ID=FBpp0080787; name=Top3alpha-PA; parent=FBgn0040268,FBtr0081246; dbxref=FlyBase:FBpp0080787,FlyBase_Annotation_IDs:CG10123-PA,GB_protein:AAF53813.2,REFSEQ:NP_523602,GB_protein:AAF53813; MD5=ccfb468a2c4ff003d0609c0457401236; length=1250; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:join(19498238..19498393,19498460..19499093,19499146..19499607,19499666..19502166); ID=FBpp0080787; name=Top3alpha-PA; parent=FBgn0040268,FBtr0081246; dbxref=FlyBase:FBpp0080787,FlyBase_Annotation_IDs:CG10123-PA,GB_protein:AAF53813.2,REFSEQ:NP_523602,GB_protein:AAF53813; MD5=ccfb468a2c4ff003d0609c0457401236; length=1250; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2L:join(19498238..19498393,19498460..19499093,19499146..19499607,19499666..19502166); ID=FBpp0080787; name=Top3alpha-PA; parent=FBgn0040268,FBtr0081246; dbxref=FlyBase:FBpp0080787,FlyBase_Annotation_IDs:CG10123-PA,GB_protein:AAF53813.2,REFSEQ:NP_523602,GB_protein:AAF53813,FlyMine:FBpp0080787,modMine:FBpp0080787; MD5=ccfb468a2c4ff003d0609c0457401236; length=1250; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2L:join(19498238..19498393,19498460..19499093,19499146..19499607,19499666..19502166); ID=FBpp0080787; name=Top3alpha-PA; parent=FBgn0040268,FBtr0081246; dbxref=FlyBase:FBpp0080787,FlyBase_Annotation_IDs:CG10123-PA,GB_protein:AAF53813.2,REFSEQ:NP_523602,GB_protein:AAF53813,FlyMine:FBpp0080787,modMine:FBpp0080787; MD5=ccfb468a2c4ff003d0609c0457401236; length=1250; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:join(19498238..19498393,19498460..19499093,19499146..19499607,19499666..19502166); ID=FBpp0080787; name=Top3alpha-PA; parent=FBgn0040268,FBtr0081246; dbxref=FlyBase:FBpp0080787,FlyBase_Annotation_IDs:CG10123-PA,GB_protein:AAF53813.2,REFSEQ:NP_523602,GB_protein:AAF53813,FlyMine:FBpp0080787,modMine:FBpp0080787; MD5=ccfb468a2c4ff003d0609c0457401236; length=1250; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0080787 type=protein; loc=2L:join(19498238..19498393,19498460..19499093,19499146..19499607,19499666..19502166); ID=FBpp0080787; name=Top3alpha-PA; parent=FBgn0040268,FBtr0081246; dbxref=FlyBase:FBpp0080787,FlyBase_Annotation_IDs:CG10123-PA,GB_protein:AAF53813.2,REFSEQ:NP_523602,GB_protein:AAF53813,FlyMine:FBpp0080787,modMine:FBpp0080787; MD5=ccfb468a2c4ff003d0609c0457401236; length=1250; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2L:join(19498238..19498393,19498460..19499093,19499146..19499607,19499666..19502166); ID=FBpp0080787; name=Top3alpha-PA; parent=FBgn0040268,FBtr0081246; dbxref=FlyBase:FBpp0080787,FlyBase_Annotation_IDs:CG10123-PA,GB_protein:AAF53813.2,REFSEQ:NP_523602,GB_protein:AAF53813,UniProt/Swiss-Prot:Q9NG98,FlyMine:FBpp0080787,modMine:FBpp0080787; MD5=ccfb468a2c4ff003d0609c0457401236; length=1250; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1250 amino acids
Gene Ontology:
Cellular Component:	chromosome [IEA]
Biological Process:	double-strand break repair via homologous recombination [IMP] DNA topological change [IEA] DNA metabolic process [IEA] DNA unwinding involved in replication [IEA]
Molecular Function:	zinc ion binding [IEA] DNA topoisomerase activity [IDA] DNA topoisomerase type I activity [ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKAVLTCFRP VVASHRRYCA NPGQAMKYLN VAEKNDAAKT IAGLLSNGAA QRREGYSVYN  60
   61 KVFDFEAPVR GQNAKMVMTS VSGHMMQLAF QVSYKNWRTV DPRSLFDAPV KKGVGSDYEP 120
  121 IKRTLEREVR GCQGLIIWTD CDREGENIGY EIIDVCRAIK PNISVYRATF SEITTVAVRR 180
  181 ALQQLGQPDK RQSDAVDVRT ELDLRTGAAI TRFQTMRLQR LFPEKIADKL ISYGSCQIPT 240
  241 LGFVAERYKE IEAFVSEPFW KIKVLHTIDD LTVEFNWARN RLFDKEACEN YLLLCLAEPD 300
  301 PRALVESVTV KPKHKWRPTP LDTVEMEKLG SRKLKLSAKE TMTIAEKLYT KGFISYPRTE 360
  361 TNQFSKEFAL APLVEMQTGH RDWGAFAQRV IEWGPNPRNG NKSDQAHPPI HPTKLAENLQ 420
  421 GNEARVYELV VRHFLACVSK DAVGSETLVH IDIAGEKFTA NGLVIHERNY LDVYVYDKWS 480
  481 AKQIHHYENG QRFEPTEVSL HEGATTAPPL LTEADLIALM EKHGIGTDAT HAEHINTIKE 540
  541 RGYIGVLDKG FLVPGVIGMG LYEGYDAMEL ALAKPQLRAE FELDLKLICQ GQKDPKVVLT 600
  601 EQIAKYKQAY QQITDKITAM DAKISARINE TPAANSAVQE GADGSAPSHG IIQSIFQCPK 660
  661 CNEAPLALKP KKNQQGWYIG CNNFPDCKNA VWLPTECKDA SVLDECCPTC GDGYRMLKFR 720
  721 LSTPYYRGVF GTPSGWYKTC LPCDNLFRTT FNINLDSVKK VGGIVGEVRG GGGGPGPGPG 780
  781 GGGSGRGAGS GGWSSGPGGG GSGGGGGSGG WGSGTGGGGS GGWGSGTGGG GLGGGKGKKP 840
  841 GGESKKSATK KPPNEPKPKK TKEPKAAPNK KTSSKSSGSI RSFFTSAAPT NSASNGLDEF 900
  901 FDSNDGFEDA MLAAAESVES SSQPKTISMV PLDDDIAAAF AADDDAEFEA LVNGGTMPTE 960
  961 SNGDQQLDKS LSEWIKEQDK ADERPMLWGT RERASLGTAA PTPPPKPAAK RPRWDSVERD1020
 1021 STPPSSVPES ETVLCTGCQQ PARQNTVRKN GPNLGRLYYK CPKPDECNFF QWADEPPSSA1080
 1081 KSKNSTGSAP QSTTSWGSNR VVTLPSIQQS NSQRGQSSMR SNSSSTVTIT QTKTKQQERN1140
 1141 TATPGDGEEV MCNCGQLASQ LTVRKDGPNQ GRPFYACPTR EKSCGFFKWG DEDQNQGASS1200
 1201 TSWGSANRNP PGRSQPTAIT SDGPKTRRCG LCRKEGHTRN KCPRKDEFDM

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.93

Protein Overview: Top3alpha-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: