Protein Overview: tos-PA

General Information:
Name(s) found:	tos-PA / FBpp0080675 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|74873405\|sp\|Q24558.1\|EXO1_DROME RecName: Full=Exonuclease 1; AltName: Full=Exonuclease I; AltName: Full=Protein tosca [NCBI NR] gi\|7298467\|gb\|AAF53687.1\| tosca [Drosophila melanogaster] [NCBI NR] gi\|223029525\|gb\|ACM78484.1\| FI07641p [Drosophila melanogaster] [NCBI NR] gi\|17137168\|ref\|NP_477145.1\| tosca [Drosophila melanogaster] [NCBI NR] gi\|1419491\|emb\|CAA61431.1\| Tosca [Drosophila melanogaster] [NCBI NR] Exonuclease 1 OS=Drosophila melanogaster GN=tos PE=1 SV=1 [Swiss-Prot] The gene tosca is referred to in FlyBase by the symbol Dmel\tos (CG10387, FBgn0015553). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:18679630..18682155. It has the cytological map location 36F11. Based on sequence similarity, it is predicted to have molecular function</span>: exodeoxyribonuclease I activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: DNA repair. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG10387-PA translation from_gene[CG10387 tos FBgn0015553] seq_release:3 mol_weight=83182 cds_boundaries:(2L:18,657,791..18,660,041[-]) aa_length:732 transcript_info:[CG10387-RA seq_release:3] gene_info:[gene symbol:tos FBgn0015553 gene_boundaries:(2L: [hmr_yeast5_DM3-1_pombe.fasta] (Q24558) TOS protein [DrosMelano7227.FASTAC.txt] (AE003660) tos gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG10387-PA [Drosophila melanogaster]gi\|17137168\|ref\|NP_477145.1\| CG10387-PA [Drosophila melanogaster]gi\|1419491\|emb\|CAA61431.1\| Tosca [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=2L:complement(18679705..18681099,18681155..18681958); ID=FBpp0080675; name=tos-PA; parent=FBgn0015553,FBtr0081131; dbxref=GB_protein:AAF53687.1,FlyBase:FBpp0080675,FlyBase_Annotation_IDs:CG10387-PA,REFSEQ:NP_477145,GB_protein:AAF53687; M [fly-100309-contam.fasta] Exonuclease 1 (Exonuclease I) (Protein tosca) [nr-271106-contam.fasta] Tosca [Drosophila melanogaster] [nr-271106-contam.fasta] CG10387-PA [Drosophila melanogaster] [nr-271106-contam.fasta] tosca CG10387-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2L:complement(18679705..18681099,18681155..18681958); ID=FBpp0080675; name=tos-PA; parent=FBgn0015553,FBtr0081131; dbxref=GB_protein:AAF53687.1,FlyBase:FBpp0080675,FlyBase_Annotation_IDs:CG10387-PA,REFSEQ:NP_477145,GB_protein:AAF53687; MD5=396bf5591fcce1421600c6fce9a351bc; length=732; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:complement(18679705..18681099,18681155..18681958); ID=FBpp0080675; name=tos-PA; parent=FBgn0015553,FBtr0081131; dbxref=GB_protein:AAF53687.1,FlyBase:FBpp0080675,FlyBase_Annotation_IDs:CG10387-PA,REFSEQ:NP_477145,GB_protein:AAF53687; MD5=396bf5591fcce1421600c6fce9a351bc; length=732; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2L:complement(18679705..18681099,18681155..18681958); ID=FBpp0080675; name=tos-PA; parent=FBgn0015553,FBtr0081131; dbxref=GB_protein:AAF53687.1,FlyBase:FBpp0080675,FlyBase_Annotation_IDs:CG10387-PA,REFSEQ:NP_477145,GB_protein:AAF53687,FlyMine:FBpp0080675,modMine:FBpp0080675; MD5=396bf5591fcce1421600c6fce9a351bc; length=732; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2L:complement(join(18681155..18681958,18679705..18681099)); ID=FBpp0080675; name=tos-PA; parent=FBgn0015553,FBtr0081131; dbxref=GB_protein:AAF53687.1,FlyBase:FBpp0080675,FlyBase_Annotation_IDs:CG10387-PA,REFSEQ:NP_477145,GB_protein:AAF53687,FlyMine:FBpp0080675,modMine:FBpp0080675; MD5=396bf5591fcce1421600c6fce9a351bc; length=732; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:complement(join(18681155..18681958,18679705..18681099)); ID=FBpp0080675; name=tos-PA; parent=FBgn0015553,FBtr0081131; dbxref=GB_protein:AAF53687.1,FlyBase:FBpp0080675,FlyBase_Annotation_IDs:CG10387-PA,REFSEQ:NP_477145,GB_protein:AAF53687,FlyMine:FBpp0080675,modMine:FBpp0080675; MD5=396bf5591fcce1421600c6fce9a351bc; length=732; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0080675 type=protein; loc=2L:complement(join(18681155..18681958,18679705..18681099)); ID=FBpp0080675; name=tos-PA; parent=FBgn0015553,FBtr0081131; dbxref=GB_protein:AAF53687.1,FlyBase:FBpp0080675,FlyBase_Annotation_IDs:CG10387-PA,REFSEQ:NP_477145,GB_protein:AAF53687,FlyMine:FBpp0080675,modMine:FBpp0080675; MD5=396bf5591fcce1421600c6fce9a351bc; length=732; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2L:complement(join(18681155..18681958,18679705..18681099)); ID=FBpp0080675; name=tos-PA; parent=FBgn0015553,FBtr0081131; dbxref=GB_protein:AAF53687.1,FlyBase:FBpp0080675,FlyBase_Annotation_IDs:CG10387-PA,REFSEQ:NP_477145,GB_protein:AAF53687,UniProt/Swiss-Prot:Q24558,FlyMine:FBpp0080675,modMine:FBpp0080675; MD5=396bf5591fcce1421600c6fce9a351bc; length=732; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	732 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	DNA repair [IEA]
Molecular Function:	DNA binding [IEA] nuclease activity [NAS] exodeoxyribonuclease I activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGITGLIPFV GKASSQLHLK DIRGSTVAVD TYCWLHKGVF GCAEKLARGE DTDVYIQYCL  60
   61 KYVNMLLSYD IKPILVFDGQ HLPAKALTEK RRRDSRKQSK ERAAELLRLG RIEEARSHMR 120
  121 RCVDVTHDMA LRLIRECRSR NVDCIVAPYE ADAQMAWLNR ADVAQYIITE DSDLTLFGAK 180
  181 NIIFKLDLNG SGLLVEAEKL HLAMGCTEEK YHFDKFRRMC ILSGCDYLDS LPGIGLAKAC 240
  241 KFILKTEQED MRIALKKIPS YLNMRNLEVD DDYIENFMKA EATFRHMFIY NPLERRMQRL 300
  301 CALEDYETDE RYCSNAGTLL EDSEQALHLA LGNLNPFSMK RLDSWTPEKA WPTPKNVKRS 360
  361 KHKSIWQTNF QSENTHTPKK ENPCALFFKK VDFVGKTLNE EIEANQRLEQ AKQTEAELFN 420
  421 MYSFKAKRRR SPSREDSVDQ ERTPPPSPVH KSRHNPFAKE RTGEEANQRS PVVCENASLL 480
  481 RLLSPKKASP LDGEAGVKKV DSLKRSIFAK EQVQIRSRFF ATQDEQTRLQ REHLRDTEND 540
  541 DMDEQKLSSH SGHKKLRLVC KDIPGKNPIR QRCSSQISDG ETDTDTTASS LLESQDKGVP 600
  601 SPLESQEDLN NSQPQIPTEG NTNSTTIRIK SLDLLLENSP EPTQESDRNN NDAIILLSDD 660
  661 SCSSDQRASS TSSSSQQRQN FLPTSKRRVG LSKPSTAKKG TPKSRTNGKL GAVSQNQTKL 720
  721 SMFGFQTKPV LK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.93

Protein Overview: tos-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: