Protein Overview: Tig-PA, FBpp0309850

General Information:
Name(s) found:	FBpp0309850 [FlyBase] Tig-PA / FBpp0078905 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|17136984\|ref\|NP_477033.1\| tiggrin [Drosophila melanogaster] [NCBI NR] gi\|10728607\|gb\|AAF52380.2\| tiggrin [Drosophila melanogaster] [NCBI NR] Tiggrin OS=Drosophila melanogaster GN=Tig PE=1 SV=2 [Swiss-Prot] type=protein; loc=2L:complement(6415436..6415498,6415557..6417584,6417658..6418617,6418686..6421951,6422260..6422509); ID=FBpp0309850; name=Tig-PB; parent=FBgn0011722,FBtr0343152; dbxref=FlyBase:FBpp0309850,FlyBase_Annotation_IDs:CG11527-PB; MD5=ab6a0cfd5093c99baba245ee82b05c82; length=2188; release=r5.56; species=Dmel; [FlyBase] The gene Tiggrin is referred to in FlyBase by the symbol Dmel\Tig (CG11527, FBgn0011722). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:6415257..6423308. It has the cytological map location 26D1. It is reported to have molecular function</span>: binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; regulation of cell adhesion mediated by integrin; phagocytosis, engulfment. 8 alleles are reported. The phenotypes of these alleles are annotated with 30 unique terms, many of which group under: hypodermal muscle of larval abdomen; organ system; larval abdominal segment 5; abdominal oblique muscle; hypodermal muscle of larval abdominal 2; abdominal ventral longitudinal muscle 3; abdominal 7 longitudinal muscle; abdominal segment 7; abdominal 6 longitudinal muscle; multi-cell-component structure; abdominal 3 ventral longitudinal muscle 4; adult segment. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG11527-PA translation from_gene[CG11527 Tig FBgn0011722] seq_release:3 mol_weight=257449 cds_boundaries:(2L:6,407,654..6,414,724[-]) aa_length:2188 transcript_info:[CG11527-RA seq_release:3] gene_info:[gene symbol:Tig FBgn0011722 gene_boundaries:(2L: [hmr_yeast5_DM3-1_pombe.fasta] (Q9VMD9) Tig protein [DrosMelano7227.FASTAC.txt] (AE003613) Tig gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG11527-PA [Drosophila melanogaster]gi\|17136984\|ref\|NP_477033.1\| CG11527-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=2L:complement(6415436..6415498,6415557..6417584,6417658..6418617,6418686..6421951,6422260..6422509); ID=FBpp0078905; name=Tig-PA; parent=FBgn0011722,FBtr0079275; dbxref=FlyBase:FBpp0078905,FlyBase_Annotation_IDs:CG11527-PA,GB_protein:AAF [fly-100309-contam.fasta] Tiggrin CG11527-PA [Drosophila melanogaster] [nr-271106-contam.fasta] CG11527-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2L:complement(6415436..6415498,6415557..6417584,6417658..6418617,6418686..6421951,6422260..6422509); ID=FBpp0078905; name=Tig-PA; parent=FBgn0011722,FBtr0079275; dbxref=FlyBase:FBpp0078905,FlyBase_Annotation_IDs:CG11527-PA,GB_protein:AAF52380.2,REFSEQ:NP_477033,GB_protein:AAF52380; MD5=ab6a0cfd5093c99baba245ee82b05c82; length=2188; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:complement(6415436..6415498,6415557..6417584,6417658..6418617,6418686..6421951,6422260..6422509); ID=FBpp0078905; name=Tig-PA; parent=FBgn0011722,FBtr0079275; dbxref=FlyBase:FBpp0078905,FlyBase_Annotation_IDs:CG11527-PA,GB_protein:AAF52380.2,REFSEQ:NP_477033,GB_protein:AAF52380; MD5=ab6a0cfd5093c99baba245ee82b05c82; length=2188; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2L:complement(6415436..6415498,6415557..6417584,6417658..6418617,6418686..6421951,6422260..6422509); ID=FBpp0078905; name=Tig-PA; parent=FBgn0011722,FBtr0079275; dbxref=FlyBase:FBpp0078905,FlyBase_Annotation_IDs:CG11527-PA,GB_protein:AAF52380.2,REFSEQ:NP_477033,GB_protein:AAF52380,FlyMine:FBpp0078905,modMine:FBpp0078905; MD5=ab6a0cfd5093c99baba245ee82b05c82; length=2188; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] Tiggrin OS=Drosophila melanogaster GN=Tig PE=2 SV=2 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta] tiggrin [Drosophila melanogaster] [RJAZ10-comet.fasta] type=protein; loc=2L:complement(join(6422260..6422509,6418686..6421951,6417658..6418617,6415557..6417584,6415436..6415498)); ID=FBpp0078905; name=Tig-PA; parent=FBgn0011722,FBtr0079275; dbxref=FlyBase:FBpp0078905,FlyBase_Annotation_IDs:CG11527-PA,GB_protein:AAF52380.2,REFSEQ:NP_477033,GB_protein:AAF52380,FlyMine:FBpp0078905,modMine:FBpp0078905; MD5=ab6a0cfd5093c99baba245ee82b05c82; length=2188; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:complement(join(6422260..6422509,6418686..6421951,6417658..6418617,6415557..6417584,6415436..6415498)); ID=FBpp0309850; name=Tig-PB; parent=FBgn0011722,FBtr0343152; dbxref=GB_protein:AHN54185,REFSEQ:NP_001285670,FlyBase:FBpp0309850,FlyBase_Annotation_IDs:CG11527-PB; MD5=ab6a0cfd5093c99baba245ee82b05c82; length=2188; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:complement(join(6422260..6422509,6418686..6421951,6417658..6418617,6415557..6417584,6415436..6415498)); ID=FBpp0078905; name=Tig-PA; parent=FBgn0011722,FBtr0079275; dbxref=FlyBase:FBpp0078905,FlyBase_Annotation_IDs:CG11527-PA,GB_protein:AAF52380.2,REFSEQ:NP_477033,GB_protein:AAF52380,FlyMine:FBpp0078905,modMine:FBpp0078905; MD5=ab6a0cfd5093c99baba245ee82b05c82; length=2188; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=2L:complement(join(6422260..6422509,6418686..6421951,6417658..6418617,6415557..6417584,6415436..6415498)); ID=FBpp0309850; name=Tig-PB; parent=FBgn0011722,FBtr0343152; dbxref=GB_protein:AHN54185,REFSEQ:NP_001285670,FlyBase:FBpp0309850,FlyBase_Annotation_IDs:CG11527-PB; MD5=ab6a0cfd5093c99baba245ee82b05c82; length=2188; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] Isoform of Q9VMD9, Tiggrin, isoform B OS=Drosophila melanogaster GN=Tig PE=1 SV=1 [DROME.fasta.20160308] FBpp0078905 type=protein; loc=2L:complement(join(6422260..6422509,6418686..6421951,6417658..6418617,6415557..6417584,6415436..6415498)); ID=FBpp0078905; name=Tig-PA; parent=FBgn0011722,FBtr0079275; dbxref=FlyBase:FBpp0078905,FlyBase_Annotation_IDs:CG11527-PA,GB_protein:AAF52380.2,REFSEQ:NP_477033,GB_protein:AAF52380,FlyMine:FBpp0078905,modMine:FBpp0078905; MD5=ab6a0cfd5093c99baba245ee82b05c82; length=2188; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0309850 type=protein; loc=2L:complement(join(6422260..6422509,6418686..6421951,6417658..6418617,6415557..6417584,6415436..6415498)); ID=FBpp0309850; name=Tig-PB; parent=FBgn0011722,FBtr0343152; dbxref=GB_protein:AHN54185,REFSEQ:NP_001285670,FlyBase:FBpp0309850,FlyBase_Annotation_IDs:CG11527-PB; MD5=ab6a0cfd5093c99baba245ee82b05c82; length=2188; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2L:complement(join(6422260..6422509,6418686..6421951,6417658..6418617,6415557..6417584,6415436..6415498)); ID=FBpp0078905; name=Tig-PA; parent=FBgn0011722,FBtr0079275; dbxref=FlyBase:FBpp0078905,FlyBase_Annotation_IDs:CG11527-PA,GB_protein:AAF52380.2,REFSEQ:NP_477033,GB_protein:AAF52380,UniProt/Swiss-Prot:Q9VMD9,FlyMine:FBpp0078905,modMine:FBpp0078905; MD5=ab6a0cfd5093c99baba245ee82b05c82; length=2188; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=2L:complement(join(6422260..6422509,6418686..6421951,6417658..6418617,6415557..6417584,6415436..6415498)); ID=FBpp0309850; name=Tig-PB; parent=FBgn0011722,FBtr0343152; dbxref=GB_protein:AHN54185,REFSEQ:NP_001285670,FlyBase:FBpp0309850,FlyBase_Annotation_IDs:CG11527-PB,UniProt/Swiss-Prot:Q9VMD9; MD5=ab6a0cfd5093c99baba245ee82b05c82; length=2188; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	2188 amino acids
Gene Ontology:
Cellular Component:	proteinaceous extracellular matrix [IDA][ISS][NAS]
Biological Process:	regulation of cell adhesion mediated by integrin [IGI] phagocytosis, engulfment [IMP] axon guidance [IMP]
Molecular Function:	binding [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRALGGITLL LAVAICQGYE TYQRSSFRSS SSSSYGGGQT VPQLNSFASA HFNEVRELAN  60
   61 QLKQKFNVLS QGSTNFAYTS PWSASILDLS GKSTLQLDQL SSEISRQLVQ DMREGITNYH 120
  121 TIAQPNFFEA KAAELLERYS GAESASLQQT VGLGPYQPVD LSGFDEVKNY AYPAEVKVID 180
  181 GKTYVVHRNC TEATKLSDYG SSGQLNSGFL GHQQTSLPLS STTTTITRKK TIHDWVRENM 240
  241 EPSVVGYNSV VKLDGQLRNS ALNQMVPLSP GSNVVIHRFN KTITTNPDGT SSVGGSEWQQ 300
  301 RWQDGKLVYD HQQPFGQSTI PRDEQWKREE RERLFWYLTT PQRLDDWQQQ QEERLLGVVQ 360
  361 RYQVSLPVLK EFHRRELARY EALLGQYQSR VQDTSSWQRQ ERGRLDWLIH QNGFTVQDIE 420
  421 RWQNENARKL AEAARQHGIS QNQLQQFQRE ELQRLYVHFN QVNESLAPQV PSVPQTTYNY 480
  481 QSSSSLTEDN TKEQQRLEEL IRQHNATIAA LQNSIKTDQQ RLKNLSIKYQ GDMQSQTQWL 540
  541 RGEVARIGDL IKEQNEQVSK ITAWQSSERS RLENILLQHR GSVEEVQQRI NMDRNYLQNL 600
  601 ATKYQVSVEE LEKWQKEELE RLQVRGQQQL EEHIKDWQIS VSSNLRDIAT QNKLTIDEFQ 660
  661 NYIINDRSHL EEMARLYKVK VEEIEQWIKS ELKKFQSEGL LKGVEQELIQ WQQKERERLQ 720
  721 AIVQQNSLTV EQLEVRIKND QDHFFKLADK YKINVEDIQD WLKKELLRLQ SEGLVKAETL 780
  781 KEWQQQERAQ ISLLVQQNKY SLDEFERKML ADRARLQELS NTYNVKVSEI EQWIKSEGDR 840
  841 LQHEGQLRME SQLNNWQKIE RQRLLDLINK NNLSIEEIES KISKDQTHLY SLAQQHQVRV 900
  901 EEIEQWIRQQ IQKLQDQGLI EMQKLKNWQL EWRGNLTNMV QDRDFTVEEF HKWLLKDREQ 960
  961 LQSLAMQHNV QIEEIEQFVK KEEQRFIGMG LLKPSEKLTN WQEVERLHLK NLAQQQYKST1020
 1021 EQLEARLRQD RELLERLARQ YSVQVEEIES WMKQELARMR DEGQLQIDNL TSWQLAERER1080
 1081 LEALIKQNKQ WSAEELRAEL EKDREHMQTM AFQYHTSVEE IEKWLQSEIE RLKQQGKLNI1140
 1141 EQLTAWQRTE QQRILSLLQQ HSNITLEQFQ AKVHNDRRFL MNLAEQHHVH IEEVDNYVKQ1200
 1201 VIEDLRKNGQ FEIEQLQTWQ RVERDYIKSL ISEYKNSLST AEYEEKLLAD RAHLKHLADQ1260
 1261 YRINVEQIEE WMIAELKRLR GSTEETLKSL SAWQVSELER LQNLVKQQNH LTFVEFEMEL1320
 1321 NQERDRLQKL ANQYSVNVVE IEEWLRQQLI NLRTTGQAKV ENLSKWQVEE QQRLIEMLLK1380
 1381 KQQEMPYEQV ERELTQDHAR LQSLSQTHHV DIDHVDHWLR EELRRLQSSG LVQIEQQTQW1440
 1441 QQKISNGFNN WLEQQRNGAS YQDFVDFLKR DKQRMDGIAT DYHVTVEQVE KWVQKEAARL1500
 1501 SLIGVIERPE NNLKYEDISN IWVGDQTDSW KNELVTRLRS VTRQRPFTRQ EFESYLIRNK1560
 1561 PIFEQIARQY HVTIEDIHLW LDQSAKNEGL VTTEWQAKER LHIDNLINQQ LRKQQRWTIE1620
 1621 ELELRLNNDQ KHLQDAVAQY HVTVEELKVW YKDELNRLLE QRRIDRGSGI SWQNIESQRI1680
 1681 YLAIVNNPGI SRQALENRLF RDVHVRASQY QITVEELRQF ILSQLRRFSD MGLIVDNGRQ1740
 1741 ANNWHDQERK RLREVVKGVV ITEQELLDFI SQDTSFQTQL AQSYQVGLEQ LAPVQRIFIG1800
 1801 NLAREQLLEQ RRLNHLTTWQ QRERDRLYEF IGNQNMTQTE LKTWQIQDSK LLAEFAKRYE1860
 1861 ISVQQLSDWQ KKELARINQL ARYYGMSQSD LQQFREGELR QLAYINHRQL LSAAEAQKWE1920
 1921 KRHQWTLSRL QSRYGKFGQE LVAWRRTLYL LSQGLIDLPA DSGSNGGYVV DAGSTNATAV1980
 1981 YKPIFSKDRG DQPPHTYDES FVEGDEPGLE GETARPRPPN PAPIVSTPKP PLPYSRGGPS2040
 2041 GGFEYRRQDY TFNVPVGSAS ASASGGPTGS SASASASLGK WNRASGDEPL QQEVDLGQQQ2100
 2101 QIEELGWNEK LEDLGQQTQV EDTDWNQQAE DLGQQQQVQV EDDLHFDQTQ GHSSSSNSRS2160
 2161 QPLQQATKVE VEATSEPSFW EKLKEKLG

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: Tig-PA, FBpp0309850

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: