Protein Overview: ade2-PB, ade2-PA...

General Information:
Name(s) found:	ade2-PC / FBpp0078852 [FlyBase] ade2-PB / FBpp0078851 [FlyBase] ade2-PA / FBpp0078850 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7297060\|gb\|AAF52329.1\| adenosine 2, isoform A [Drosophila melanogaster] [NCBI NR] gi\|24582111\|ref\|NP_723147.1\| adenosine 2, isoform C [Drosophila melanogaster] [NCBI NR] gi\|24582109\|ref\|NP_723146.1\| adenosine 2, isoform B [Drosophila melanogaster] [NCBI NR] gi\|22945731\|gb\|AAN10574.1\| adenosine 2, isoform C [Drosophila melanogaster] [NCBI NR] gi\|22945730\|gb\|AAN10573.1\| adenosine 2, isoform B [Drosophila melanogaster] [NCBI NR] gi\|17137292\|ref\|NP_477212.1\| adenosine 2, isoform A [Drosophila melanogaster] [NCBI NR] gi\|12643275\|sp\|P35421.2\|PUR4_DROME RecName: Full=Phosphoribosylformylglycinamidine synthase; Short=FGAM synthase; Short=FGAMS; AltName: Full=Formylglycinamide ribotide amidotransferase; Short=FGARAT; AltName: Full=Formylglycinamide ribotide synthetase; Al [NCBI NR] Phosphoribosylformylglycinamidine synthase OS=Drosophila melanogaster GN=ade2 PE=1 SV=2 [Swiss-Prot] The gene adenosine 2 is referred to in FlyBase by the symbol Dmel\ade2 (CG9127, FBgn0000052). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:6041178..6045970. It has the cytological map location 26B3. Based on sequence similarity, it is predicted to have molecular function</span>: phosphoribosylformylglycinamidine synthase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: 'de novo' IMP biosynthetic process. 16 alleles are reported. The phenotypes of these alleles are annotated with: genitalia; ventral row; posterior crossvein; dorsal row; wing; ocellus pigment granule; wing vein; macrochaeta; pigment cell; trichome of the posterior wing margin. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase] >CG9127-PC translation from_gene[CG9127 ade2 FBgn0000052] seq_release:3 mol_weight=148087 cds_boundaries:(2L:6,033,532..6,037,732[-]) aa_length:1354 transcript_info:[CG9127-RC seq_release:3] gene_info:[gene symbol:ade2 FBgn0000052 gene_boundaries:(2L:6 [hmr_yeast5_DM3-1_pombe.fasta] >CG9127-PB translation from_gene[CG9127 ade2 FBgn0000052] seq_release:3 mol_weight=148087 cds_boundaries:(2L:6,033,532..6,037,732[-]) aa_length:1354 transcript_info:[CG9127-RB seq_release:3] gene_info:[gene symbol:ade2 FBgn0000052 gene_boundaries:(2L:6 [hmr_yeast5_DM3-1_pombe.fasta] >CG9127-PA translation from_gene[CG9127 ade2 FBgn0000052] seq_release:3 mol_weight=148087 cds_boundaries:(2L:6,033,532..6,037,732[-]) aa_length:1354 transcript_info:[CG9127-RA seq_release:3] gene_info:[gene symbol:ade2 FBgn0000052 gene_boundaries:(2L:6 [hmr_yeast5_DM3-1_pombe.fasta] (P35421) Phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) (FGAM synthase) (FGAMS) (Formylglycinamide ribotide amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase) (Adenosine-2) [DrosMelano7227.FASTAC.txt] (AE003612) ade2 gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG9127-PC, isoform C [Drosophila melanogaster]gi\|22945730\|gb\|AAN10573.1\| CG9127-PB, isoform B [Drosophila melanogaster]gi\|7297060\|gb\|AAF52329.1\| CG9127-PA, isoform A [Drosophila melanogaster]gi\|24582111\|ref\|NP_723147.1\| CG9127-PC [Drosophila melanogast [nrdb_11152004_Chlamydomonas] type=protein; loc=2L:complement(6041314..6042011,6042075..6044351,6044428..6045517); ID=FBpp0078850; name=ade2-PA; parent=FBgn0000052,FBtr0079219; dbxref=FlyBase:FBpp0078850,FlyBase_Annotation_IDs:CG9127-PA,GB_protein:AAF52329.1,REFSEQ:NP_477212,GB_protei [fly-100309-contam.fasta] type=protein; loc=2L:complement(6041314..6042011,6042075..6044351,6044428..6045517); ID=FBpp0078851; name=ade2-PB; parent=FBgn0000052,FBtr0079220; dbxref=FlyBase:FBpp0078851,FlyBase_Annotation_IDs:CG9127-PB,GB_protein:AAN10573.1,REFSEQ:NP_723146,GB_protei [fly-100309-contam.fasta] type=protein; loc=2L:complement(6041314..6042011,6042075..6044351,6044428..6045517); ID=FBpp0078852; name=ade2-PC; parent=FBgn0000052,FBtr0079221; dbxref=FlyBase:FBpp0078852,FlyBase_Annotation_IDs:CG9127-PC,GB_protein:AAN10574.1,REFSEQ:NP_723147,GB_protei [fly-100309-contam.fasta] CG9127-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (Formylglycinamide ribotide amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase) (Adenosine-2) [nr-271106-contam.fasta] CG9127-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] CG9127-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] adenosine 2 CG9127-PC, isoform C [Drosophila melanogaster] [nr-271106-contam.fasta] adenosine 2 CG9127-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] adenosine 2 CG9127-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=2L:complement(6041314..6042011,6042075..6044351,6044428..6045517); ID=FBpp0078850; name=ade2-PA; parent=FBgn0000052,FBtr0079219; dbxref=FlyBase:FBpp0078850,FlyBase_Annotation_IDs:CG9127-PA,GB_protein:AAF52329.1,REFSEQ:NP_477212,GB_protein:AAF52329; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:complement(6041314..6042011,6042075..6044351,6044428..6045517); ID=FBpp0078851; name=ade2-PB; parent=FBgn0000052,FBtr0079220; dbxref=FlyBase:FBpp0078851,FlyBase_Annotation_IDs:CG9127-PB,GB_protein:AAN10573.1,REFSEQ:NP_723146,GB_protein:AAN10573; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:complement(6041314..6042011,6042075..6044351,6044428..6045517); ID=FBpp0078852; name=ade2-PC; parent=FBgn0000052,FBtr0079221; dbxref=FlyBase:FBpp0078852,FlyBase_Annotation_IDs:CG9127-PC,GB_protein:AAN10574.1,REFSEQ:NP_723147,GB_protein:AAN10574; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=2L:complement(6041314..6042011,6042075..6044351,6044428..6045517); ID=FBpp0078850; name=ade2-PA; parent=FBgn0000052,FBtr0079219; dbxref=FlyBase:FBpp0078850,FlyBase_Annotation_IDs:CG9127-PA,GB_protein:AAF52329.1,REFSEQ:NP_477212,GB_protein:AAF52329; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2L:complement(6041314..6042011,6042075..6044351,6044428..6045517); ID=FBpp0078851; name=ade2-PB; parent=FBgn0000052,FBtr0079220; dbxref=FlyBase:FBpp0078851,FlyBase_Annotation_IDs:CG9127-PB,GB_protein:AAN10573.1,REFSEQ:NP_723146,GB_protein:AAN10573; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2L:complement(6041314..6042011,6042075..6044351,6044428..6045517); ID=FBpp0078852; name=ade2-PC; parent=FBgn0000052,FBtr0079221; dbxref=FlyBase:FBpp0078852,FlyBase_Annotation_IDs:CG9127-PC,GB_protein:AAN10574.1,REFSEQ:NP_723147,GB_protein:AAN10574; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=2L:complement(6041314..6042011,6042075..6044351,6044428..6045517); ID=FBpp0078850; name=ade2-PA; parent=FBgn0000052,FBtr0079219; dbxref=FlyBase:FBpp0078850,FlyBase_Annotation_IDs:CG9127-PA,GB_protein:AAF52329.1,REFSEQ:NP_477212,GB_protein:AAF52329,FlyMine:FBpp0078850,modMine:FBpp0078850; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2L:complement(6041314..6042011,6042075..6044351,6044428..6045517); ID=FBpp0078851; name=ade2-PB; parent=FBgn0000052,FBtr0079220; dbxref=FlyBase:FBpp0078851,FlyBase_Annotation_IDs:CG9127-PB,GB_protein:AAN10573.1,REFSEQ:NP_723146,GB_protein:AAN10573; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2L:complement(6041314..6042011,6042075..6044351,6044428..6045517); ID=FBpp0078852; name=ade2-PC; parent=FBgn0000052,FBtr0079221; dbxref=FlyBase:FBpp0078852,FlyBase_Annotation_IDs:CG9127-PC,GB_protein:AAN10574.1,REFSEQ:NP_723147,GB_protein:AAN10574; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=2L:complement(join(6044428..6045517,6042075..6044351,6041314..6042011)); ID=FBpp0078850; name=ade2-PA; parent=FBgn0000052,FBtr0079219; dbxref=FlyBase:FBpp0078850,FlyBase_Annotation_IDs:CG9127-PA,GB_protein:AAF52329.1,REFSEQ:NP_477212,GB_protein:AAF52329,FlyMine:FBpp0078850,modMine:FBpp0078850; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:complement(join(6044428..6045517,6042075..6044351,6041314..6042011)); ID=FBpp0078851; name=ade2-PB; parent=FBgn0000052,FBtr0079220; dbxref=FlyBase:FBpp0078851,FlyBase_Annotation_IDs:CG9127-PB,GB_protein:AAN10573.1,REFSEQ:NP_723146,GB_protein:AAN10573; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:complement(join(6044428..6045517,6042075..6044351,6041314..6042011)); ID=FBpp0078852; name=ade2-PC; parent=FBgn0000052,FBtr0079221; dbxref=FlyBase:FBpp0078852,FlyBase_Annotation_IDs:CG9127-PC,GB_protein:AAN10574.1,REFSEQ:NP_723147,GB_protein:AAN10574; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=2L:complement(join(6044428..6045517,6042075..6044351,6041314..6042011)); ID=FBpp0078851; name=ade2-PB; parent=FBgn0000052,FBtr0079220; dbxref=FlyBase:FBpp0078851,FlyBase_Annotation_IDs:CG9127-PB,GB_protein:AAN10573.1,REFSEQ:NP_723146,GB_protein:AAN10573; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=2L:complement(join(6044428..6045517,6042075..6044351,6041314..6042011)); ID=FBpp0078852; name=ade2-PC; parent=FBgn0000052,FBtr0079221; dbxref=FlyBase:FBpp0078852,FlyBase_Annotation_IDs:CG9127-PC,GB_protein:AAN10574.1,REFSEQ:NP_723147,GB_protein:AAN10574; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=2L:complement(join(6044428..6045517,6042075..6044351,6041314..6042011)); ID=FBpp0078850; name=ade2-PA; parent=FBgn0000052,FBtr0079219; dbxref=FlyBase:FBpp0078850,FlyBase_Annotation_IDs:CG9127-PA,GB_protein:AAF52329.1,REFSEQ:NP_477212,GB_protein:AAF52329,FlyMine:FBpp0078850,modMine:FBpp0078850; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0078850 type=protein; loc=2L:complement(join(6044428..6045517,6042075..6044351,6041314..6042011)); ID=FBpp0078850; name=ade2-PA; parent=FBgn0000052,FBtr0079219; dbxref=FlyBase:FBpp0078850,FlyBase_Annotation_IDs:CG9127-PA,GB_protein:AAF52329.1,REFSEQ:NP_477212,GB_protein:AAF52329,FlyMine:FBpp0078850,modMine:FBpp0078850; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0078851 type=protein; loc=2L:complement(join(6044428..6045517,6042075..6044351,6041314..6042011)); ID=FBpp0078851; name=ade2-PB; parent=FBgn0000052,FBtr0079220; dbxref=FlyBase:FBpp0078851,FlyBase_Annotation_IDs:CG9127-PB,GB_protein:AAN10573.1,REFSEQ:NP_723146,GB_protein:AAN10573; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0078852 type=protein; loc=2L:complement(join(6044428..6045517,6042075..6044351,6041314..6042011)); ID=FBpp0078852; name=ade2-PC; parent=FBgn0000052,FBtr0079221; dbxref=FlyBase:FBpp0078852,FlyBase_Annotation_IDs:CG9127-PC,GB_protein:AAN10574.1,REFSEQ:NP_723147,GB_protein:AAN10574; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=2L:complement(join(6044428..6045517,6042075..6044351,6041314..6042011)); ID=FBpp0078850; name=ade2-PA; parent=FBgn0000052,FBtr0079219; dbxref=FlyBase:FBpp0078850,FlyBase_Annotation_IDs:CG9127-PA,GB_protein:AAF52329.1,REFSEQ:NP_477212,GB_protein:AAF52329,UniProt/Swiss-Prot:P35421,FlyMine:FBpp0078850,modMine:FBpp0078850; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=2L:complement(join(6044428..6045517,6042075..6044351,6041314..6042011)); ID=FBpp0078851; name=ade2-PB; parent=FBgn0000052,FBtr0079220; dbxref=FlyBase:FBpp0078851,FlyBase_Annotation_IDs:CG9127-PB,GB_protein:AAN10573.1,REFSEQ:NP_723146,GB_protein:AAN10573,UniProt/Swiss-Prot:P35421; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=2L:complement(join(6044428..6045517,6042075..6044351,6041314..6042011)); ID=FBpp0078852; name=ade2-PC; parent=FBgn0000052,FBtr0079221; dbxref=FlyBase:FBpp0078852,FlyBase_Annotation_IDs:CG9127-PC,GB_protein:AAN10574.1,REFSEQ:NP_723147,GB_protein:AAN10574,UniProt/Swiss-Prot:P35421; MD5=09681b451735dd717183b2da884dc540; length=1354; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1354 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	'de novo' IMP biosynthetic process [ISS][NAS]
Molecular Function:	phosphoribosylformylglycinamidine synthase activity [ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVILRYYDVQ AHSAAEEESV LRRLREEDGA VVSVRMERCY HLEYSAQAEH SLALDELLVW  60
   61 LVKQPLSKGQ SLSRQPALQS TGSSQLLLEI GPRFNFSTPY STNCVNIFQN LGYSEVRRME 120
  121 TSTRYLVTFG EGSKAPEAAR FVPLLGDRMT QCLYTEENTP KASFDEQLPE RQANWHFVPV 180
  181 LEEGRAALER INQELGLAFN DYDLDYYHDL FAKELGRNPT TVELFDCAQS NSEHSRHWFF 240
  241 RGRMVIDGVE QPKSLIRMIM DTQAHTNPNN TIKFSDNSSA MVGFDHQTIV PSSVVAPGAV 300
  301 RLQSVQSDLI FTAETHNMPT AVAPFSGATT GTGGRLRDVQ GVGRGGVPIA GTAGYCVGAL 360
  361 HIPGYKQPYE PLDFKYPATF APPLQVLIEA SNGASDYGNK FGEPVISGFA LSYGLNSAAD 420
  421 ASQRDEYVKP IMFSGGLGTM PATMREKLPP ARGQLLAKIG GPVYRIGVGG GAASSVEIQG 480
  481 SGDAELDFNA VQRGDAEMEN KLNRVVRACL DLGEQNPILA IHDQGAGGNG NVLKELVEPG 540
  541 FAGAVIFSKE FQLGDPTITA LELWGAEYQE NNAILCNADQ RELLEKICRR ERCPISFVGV 600
  601 VTGDGRVTLL EKPAPKDLEQ ALNASNRSEV SPFDLELKYV LGDMPKRTYD LKREQTPLKE 660
  661 LSLPKGLLLD EALERVLSLV AVGSKRFLTN KVDRCVGGLI AQQQCVGPLQ APLADYALTT 720
  721 VSHFSHSGIA TSIGTQPLKG LLDPAAMARM CVAEALSNLV FVKISELADV KCSGNWMWAA 780
  781 KLPGEGARMF DACKELCQIL EELHIAIDGG KDSLSMAAKV GGETIKSPGT LVISTYAPCP 840
  841 DVRLKVTPDL KGPGAGSKTS LLWINLENSA RLGGSALAQA YAQQGKDTPN LTRSDVLGKA 900
  901 FAVTQSLLGD GLIQAGHDVS DGGLLVCVLE MAIGGLSGLR VDLSEPLAKL KNFDKSVEKL 960
  961 NRPELAVLFA EECGWVVEVL DTDLERVRST YEKAGVPNYY LGVTEGFGLD SRVVLKNGKS1020
 1021 ELLDQPLRVL YKKWERTSYE LEKLQANPEC AEAEYNSLEY RQAPQYRGPQ NVQAELTLKR1080
 1081 SSAPVRVAVL REEGVNSERE MMACLLRANF EVHDVTMSDL LQGTASVSQY RGLIFPGGFS1140
 1141 YADTLGSAKG WAANILHNPR LLPQFEAFKR RQDVFSLGIC NGCQLMTLIG FVGSAKSEVG1200
 1201 ADPDVALLHN KSQRFECRWA TVKIPSNRSI MLGSMKDLVL GCWVAHGEGR FAFRDEKLIS1260
 1261 HLQSEQLVTL QYVDDVGKPT ELYPLNPNGS PQGIAGLCSS DGRHLALMPH PERCSSMYQW1320
 1321 PYVPSSFEVS PTQSESPWQI MFNNAYNWCV KSNQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Protein Overview: ade2-PB, ade2-PA...

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: