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Protein Overview: Hrs-PA

General Information:
Name(s) found: Hrs-PA / FBpp0088690 [FlyBase]
Description(s) found:
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  • gi|7295923|gb|AAF51222.1| hepatocyte growth factor regulated tyrosine kinase substrate, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|24581201|ref|NP_722831.1| hepatocyte growth factor regulated tyrosine kinase substrate, isoform A [Drosophila melanogaster] [NCBI NR]
  • The gene Hepatocyte growth factor regulated tyrosine kinase substrate is referred to in FlyBase by the symbol Dmel\Hrs (CG2903, FBgn0031450). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2L:2739986..2743377. It has the cytological map location 23A3. It is reported to have molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: endocytosis; border follicle cell migration. 13 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; wing margin bristle; oocyte; eye photoreceptor cell; wing; endosome; vesicle; larval garland cell. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • >CG2903-PA translation from_gene[CG2903 Hrs FBgn0031450] seq_release:3 mol_weight=72414 cds_boundaries:(2L:2,733,579..2,735,651[+]) aa_length:647 transcript_info:[CG2903-RA seq_release:3] gene_info:[gene symbol:Hrs FBgn0031450 gene_boundaries:(2L:2,732 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VQF3) CG2903 protein [DrosMelano7227.FASTAC.txt]
  • (AE003582) CG2903 gene product [alt 1] [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG2903-PA, isoform A [Drosophila melanogaster]gi|24581201|ref|NP_722831.1| CG2903-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2L:join(2741010..2741051,2741108..2741482,2741559..2743085); ID=FBpp0088690; name=Hrs-PA; parent=FBgn0031450,FBtr0089749; dbxref=FlyBase:FBpp0088690,FlyBase_Annotation_IDs:CG2903-PA,GB_protein:AAF51222.1,REFSEQ:NP_722831,GB_protein:AAF51 [fly-100309-contam.fasta]
  • CG2903-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Hepatocyte growth factor regulated tyrosine kinase substrate CG2903-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2L:join(2741010..2741051,2741108..2741482,2741559..2743085); ID=FBpp0088690; name=Hrs-PA; parent=FBgn0031450,FBtr0089749; dbxref=FlyBase:FBpp0088690,FlyBase_Annotation_IDs:CG2903-PA,GB_protein:AAF51222.1,REFSEQ:NP_722831,GB_protein:AAF51222; MD5=05b7bb9fe382c5870e9a3331d961bc5d; length=647; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2L:join(2741010..2741051,2741108..2741482,2741559..2743085); ID=FBpp0088690; name=Hrs-PA; parent=FBgn0031450,FBtr0089749; dbxref=FlyBase:FBpp0088690,FlyBase_Annotation_IDs:CG2903-PA,GB_protein:AAF51222.1,REFSEQ:NP_722831,GB_protein:AAF51222; MD5=05b7bb9fe382c5870e9a3331d961bc5d; length=647; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Isoform A of Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Drosophila melanogaster GN=Hrs [UniProt_drosophila_07-01-2011_reversed.fasta]
  • GH12653p OS=Drosophila melanogaster GN=Hrs-RA PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2L:join(2741010..2741051,2741108..2741482,2741559..2743085); ID=FBpp0088690; name=Hrs-PA; parent=FBgn0031450,FBtr0089749; dbxref=FlyBase:FBpp0088690,FlyBase_Annotation_IDs:CG2903-PA,GB_protein:AAF51222.1,REFSEQ:NP_722831,GB_protein:AAF51222,FlyMine:FBpp0088690,modMine:FBpp0088690; MD5=05b7bb9fe382c5870e9a3331d961bc5d; length=647; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2L:join(2741010..2741051,2741108..2741482,2741559..2743085); ID=FBpp0088690; name=Hrs-PA; parent=FBgn0031450,FBtr0089749; dbxref=FlyBase:FBpp0088690,FlyBase_Annotation_IDs:CG2903-PA,GB_protein:AAF51222.1,REFSEQ:NP_722831,GB_protein:AAF51222,FlyMine:FBpp0088690,modMine:FBpp0088690; MD5=05b7bb9fe382c5870e9a3331d961bc5d; length=647; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2L:join(2741010..2741051,2741108..2741482,2741559..2743085); ID=FBpp0088690; name=Hrs-PA; parent=FBgn0031450,FBtr0089749; dbxref=FlyBase:FBpp0088690,FlyBase_Annotation_IDs:CG2903-PA,GB_protein:AAF51222.1,REFSEQ:NP_722831,GB_protein:AAF51222,FlyMine:FBpp0088690,modMine:FBpp0088690; MD5=05b7bb9fe382c5870e9a3331d961bc5d; length=647; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q960X8, Isoform A of Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Drosophila melanogaster GN=Hrs [DROME.fasta.20160308]
  • FBpp0088690 type=protein; loc=2L:join(2741010..2741051,2741108..2741482,2741559..2743085); ID=FBpp0088690; name=Hrs-PA; parent=FBgn0031450,FBtr0089749; dbxref=FlyBase:FBpp0088690,FlyBase_Annotation_IDs:CG2903-PA,GB_protein:AAF51222.1,REFSEQ:NP_722831,GB_protein:AAF51222,FlyMine:FBpp0088690,modMine:FBpp0088690; MD5=05b7bb9fe382c5870e9a3331d961bc5d; length=647; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2L:join(2741010..2741051,2741108..2741482,2741559..2743085); ID=FBpp0088690; name=Hrs-PA; parent=FBgn0031450,FBtr0089749; dbxref=FlyBase:FBpp0088690,FlyBase_Annotation_IDs:CG2903-PA,GB_protein:AAF51222.1,REFSEQ:NP_722831,GB_protein:AAF51222,UniProt/TrEMBL:C9QP23,FlyMine:FBpp0088690,modMine:FBpp0088690; MD5=05b7bb9fe382c5870e9a3331d961bc5d; length=647; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 647 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEEELSIE EESLDTMTIL KAKGHTFPEL READAMFTAD TAPNWADGRV CHRCRVEFTF  60
   61 TNRKHHCRNC GQVFCGQCTA KQCPLPKYGI EKEVRVCDGC FAALQRPTSG SGGAKSGPRP 120
  121 ADSELPAEYL NSTLAQQVQT PARKTEQELK EEEELQLALA LSQSEAEQQK PKLQSLPPAA 180
  181 YRMQQRSPSP EAPPEPKEYH QQPEEATNPE LAKYLNRSYW EQRKISESSS MASPSAPSPM 240
  241 PPTPQPQQIM PLQVKSADEV QIDEFAANMR TQVEIFVNRM KSNSSRGRSI SNDSSVQTLF 300
  301 MTLTSLHSQQ LSYIKEMDDK RMWYEQLQDK LTQIKDSRAA LDQLRQEHVE KLRRIAEEQE 360
  361 RQRQMQMAQK LDIMRKKKQE YLQYQRQLAL QRIQEQEREM QLRQEQQKAQ YLMGQSAPPF 420
  421 PYMPPSAVPQ HGSPSHQLNN VYNPYAAGVP GYLPQGPAPA PNGHGQFQAI PPGMYNPAIQ 480
  481 QPMPPNLQPG GLMQQPAPPG NPQMMPPMPE NQFANNPAAI LQLPQQHSIA QPPQIPFQPQ 540
  541 PQQIPGQQPQ QIPGQQPQQI PGQQPQQIPG QQPQQIPVQQ PQPQPQMGHV MLQQHQAPPA 600
  601 AQAPPVTEIA NNQVQAVAAA PAPPQNEPGP APVKAEEPAT AELISFD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle