Protein Overview: IL6RB_RAT

General Information:
Name(s) found:	IL6RB_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|729835\|sp\|P40190.1\|IL6RB_RAT RecName: Full=Interleukin-6 receptor subunit beta; Short=IL-6R-beta; AltName: Full=Interleukin-6 signal transducer; AltName: Full=Membrane glycoprotein 130; Short=gp130; AltName: Full=Oncostatin-M receptor subunit alpha; Al [NCBI NR] pir\|\|A44257 interleukin-6 signal transducing molecule gp130 - rat [NCBI NR] Interleukin-6 receptor subunit beta OS=Rattus norvegicus GN=Il6st PE=1 SV=1 [Swiss-Prot] (P40190) Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (GP130) [Swiss-Prot] Ensembl_locations(Chr-bp):2-39857680 Interleukin-6 receptor beta chain precursor [hmr_yeast5_DM3-1_pombe.fasta] Interleukin-6 receptor beta chain precursor (IL-6R-beta) (Interleukin 6 signal transducer) (Membrane glycoprotein 130) (GP130)gi\|348455\|pir\|\|A44257 interleukin-6 signal transducing molecule gp130 - rat [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Interleukin-6 receptor beta chain precursor [EBI-IPI_rat_3.05_04-04-2005_origrev.fasta] Interleukin-6 receptor subunit beta precursor (IL-6R-beta) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (CD130 antigen) (Oncostatin-M receptor alpha subunit) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 INTERLEUKIN-6 RECEPTOR BETA CHAIN PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Interleukin-6 receptor subunit beta precursor (IL-6R-beta) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor alpha subunit) (CD130 antigen) [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Il6st Interleukin-6 receptor subunit beta [rat-ipi-250309-contam.fasta] Interleukin-6 receptor subunit beta OS=Rattus norvegicus GN=Il6st [011711_HMR.fasta] Interleukin-6 receptor subunit beta OS=Rattus norvegicus GN=Il6st PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	918 amino acids
Gene Ontology:
Cellular Component:	extracellular space [UNKNOWN] oncostatin-M receptor complex [UNKNOWN][IEA] membrane [IEA] ciliary neurotrophic factor receptor complex [UNKNOWN][IEA] external side of plasma membrane [UNKNOWN][IEA] integral to membrane [IEA] cellular_component [ND] interleukin-6 receptor complex [UNKNOWN][IEA]
Biological Process:	response to cytokine stimulus [UNKNOWN][IEA] positive regulation of tyrosine phosphorylation of Stat3 protein [UNKNOWN][IEA] signal transduction [UNKNOWN][IEA] regulation of Notch signaling pathway [UNKNOWN][IEA] positive regulation of cell proliferation [UNKNOWN][IEA] reduction of cytosolic calcium ion concentration [IMP] response to nutrient [IEP] positive regulation of astrocyte differentiation [UNKNOWN] positive regulation of T cell proliferation [UNKNOWN][IEA] positive regulation of osteoblast differentiation [UNKNOWN][IEA] positive regulation of tyrosine phosphorylation of Stat1 protein [UNKNOWN][IEA] triglyceride mobilization [IMP] JAK-STAT cascade [IMP] positive regulation of cell growth [TAS] glycogen metabolic process [UNKNOWN][IEA] regulation of hormone secretion [TAS] cytokine-mediated signaling pathway [UNKNOWN] leukemia inhibitory factor signaling pathway [UNKNOWN][IEA] ciliary neurotrophic factor-mediated signaling pathway [UNKNOWN][IEA] negative regulation of interleukin-6-mediated signaling pathway [UNKNOWN] positive regulation of smooth muscle cell migration [IMP] interleukin-27-mediated signaling pathway [UNKNOWN][IEA]
Molecular Function:	growth factor binding [UNKNOWN] receptor activity [IEA] cytokine activity [TAS] cytokine receptor activity [IEA] ciliary neurotrophic factor receptor binding [UNKNOWN][IEA] interleukin-6 receptor binding [UNKNOWN][IEA] ciliary neurotrophic factor receptor activity [UNKNOWN] interleukin-11 receptor activity [UNKNOWN][IEA] protein binding [UNKNOWN] oncostatin-M receptor activity [UNKNOWN][IEA] leukemia inhibitory factor receptor activity [UNKNOWN][IEA] interleukin-6 receptor activity [UNKNOWN][IEA] interleukin-11 binding [UNKNOWN] interleukin-6 binding [UNKNOWN]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSALRIWLMQ ALLIFLTTES IGQLVEPCGY IYPEFPVVQR GSNFTATCVL KEKCLQVYSV  60
   61 NATYIVWKTN HVAVPKEQVT VINRTASSVT FTDVVFQNVQ LTCNILSFGQ IEQNVYGITI 120
  121 LSGYPPDIPT NLSCIVNEGK NMLCQLDPGR ETYLETNYTL KSEWATEKFP DCRTKHGTSS 180
  181 CMMGYTPIYF VNIEVWVEAE NALGNVSSEP INFDPVDKVK PSPPHNLSVT NSEELSSILK 240
  241 LAWVNSGLDS ILRLKSDIQY RTKDASTWIQ VPLEDTVSPR TSFTVQDLKP FTEYVFRIRS 300
  301 IKENGKGYWS DWSEEASGTT YEDRPSKAPS FWYKVNANHP QEYRSARLIW KTLPLSEANG 360
  361 KILDYEVVLT QSKSVSQTYT VNGTELIVNL TNNRYVASLA ARNVVGKSPA TVLTIPGSHF 420
  421 KASHPVVDLK AFPKDNLLWV EWTPPSKPVN KYILEWCVLS ENSPCIPDWQ QEDGTVNRTH 480
  481 LRGSLLESKC YLITVTPVFP GGPGSPESMK AYLKQAAPSK GPTVRTKKVG KNEAVLEWDH 540
  541 LPVDVQNGFI RNYSISYRTS VGKEMVVRVD SSHTEYTLSS LSSDTLYMVH MAAYTEEGGK 600
  601 DGPEFTFTTL KFAQGEIEAI VVPVCLAFLL TTLLGVLFCF NKRDLIKKHI WPNVPDPSKS 660
  661 HIAQWSPHTP PRHNFNSKDQ MYSDANFTDV SVVEIEANNK KPCPDDLKSL DLFKKEKIST 720
  721 EGHSSGIGGS SCMSSSRPSI SSSEENESAQ STASTVQYST VVHSGYRHQV PSVQVFSRSE 780
  781 STQPLLDSEE RPEDLQLVDS VDSGDEILPR QQYFKQSCSQ PGASPDVSHF GRSSQVPSGS 840
  841 EEDFVRLKQQ QVSDHISEPY GSEQRRLFQE GSVADALGTG TDGQIERFES VGMETAMDED 900
  901 ISKSYLPQTV RQGGYMPQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: IL6RB_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: