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Protein Overview: PCLO_RAT

General Information:
Name(s) found: PCLO_RAT [Swiss-Prot]
Description(s) found:
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  • gi|7528227|gb|AAF63196.1| multidomain presynaptic cytomatrix protein Piccolo [Rattus norvegicus] [NCBI NR]
  • gi|24212076|sp|Q9JKS6.1|PCLO_RAT RecName: Full=Protein piccolo; AltName: Full=Aczonin; AltName: Full=Multidomain presynaptic cytomatrix protein [NCBI NR]
  • gi|10048483|ref|NP_064483.1| piccolo isoform 1 [Rattus norvegicus] [NCBI NR]
  • Protein piccolo OS=Rattus norvegicus GN=Pclo PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):4-15717761 Splice isoform 1 of Q9JKS6 [hmr_yeast5_DM3-1_pombe.fasta]
  • multidomain presynaptic cytomatrix protein Piccolo; piccolo (presynaptic cytomatrix protein) [HMR_022704-rand.fasta]
  • multidomain presynaptic cytomatrix protein Piccolo [Rattus norvegicus]gi|7528227|gb|AAF63196.1| multidomain presynaptic cytomatrix protein Piccolo [Rattus norvegicus]gi|24212076|sp|Q9JKS6|PCLO_RAT Piccolo protein (Multidomain presynaptic cytomatrix prot [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Splice Isoform 1 of Protein piccolo [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • Tax_Id=10116 Splice Isoform 1 of Piccolo protein [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta]
  • (NM_020098) multidomain presynaptic cytomatrix protein Piccolo [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • piccolo isoform 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • multidomain presynaptic cytomatrix protein Piccolo [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 SPLICE ISOFORM 1 OF PICCOLO PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Pclo Isoform 1 of Protein piccolo [rat-ipi-250309-contam.fasta]
  • Isoform 1 of Protein piccolo OS=Rattus norvegicus GN=Pclo [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 5085 amino acids

    Gene Ontology:
    Cellular Component: synaptic vesicle [IEA]
    membrane [IEA]
    cell junction [IEA]
    synapse [IDA][IEA]
    Biological Process: synaptic vesicle targeting [NAS]
    cytoskeleton organization [UNKNOWN][ISS]
    insulin secretion [UNKNOWN]
    regulation of exocytosis [UNKNOWN]
    transport [IEA]
    cAMP-mediated signaling [UNKNOWN]
    Molecular Function: zinc ion binding [IEA]
    protein binding [UNKNOWN][IEA][IPI]
    metal ion binding [IEA]
    calcium ion binding [IDA]
    transporter activity [IEA]
    profilin binding [UNKNOWN][ISS]
    calcium-dependent phospholipid binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGNEASLEGE GLPEGLAAAA GAGGSGSALH PGIPAGMEAD LSQLSEEERR QIAAVMSRAQ  60
   61 GLPKGSVPPA AAESPSMHRK QELDSSQAPQ QPGKPPDPGR PTQPGLSKSR TTDTFRSEQK 120
  121 LPGRSPSTIS LKESKSRTDF KEEYKSSMMP GFFSDVNPLS AVSSVVNKFN PFDLISDSEA 180
  181 SQEETTKKQK VVQKEQGKSE GMAKPPLQQP SPKPIPKQQG QVKEVIQQDS SPKSVSSQQA 240
  241 EKVKPQAPGT GKPSQQSPAQ TPAQQASPGK PVAQQPGSAK ATVQQPGPAK SPAQPAGTGK 300
  301 SPAQPPAKTP GQQAGLEKTS SSQQPGPKSL AQTPGHGKFP LGPVKSPAQQ PGTAKHPAQQ 360
  361 PGPQTAAKVP GPTKTPAQQS GPGKTPAQQP GPTKPSPQQP IPAKPQPQQP VATKTQPQQS 420
  421 APAKPQPQQP APAKPQPQQP TPAKPQPQPP TPAKPQPQPP TATKPQPQPP TATKPHHQQP 480
  481 GLAKPSAQQP TKSISQTVTG RPLQPPPTSA AQTPAQGLSK TICPLCNTTE LLLHIPEKAN 540
  541 FNTCTECQST VCSLCGFNPN PHLTEIKEWL CLNCQMQRAL GGDLAAAIPS SPQPTPKAAT 600
  601 APTATASKSP VPSQQASPKK EPPSKQDSPK ALESKKPPEP KKPPEPKKPP EPKKPPPLVK 660
  661 QPTLHGPTPA TAPQLPVAEA LPEPAPPKEP SGPLPEQAKA PVGDVEPKQP KMTETRADIQ 720
  721 SSSTTKPDIL SSQVQSQAQV KTASPLKTDS AKPSQSFPPT GEKTTPLDSK AMPRPASDSK 780
  781 IISQPGPGSE SKDPKHIDPI QKKDEPKKAQ PKGSPKPETK PVPKGSPTPS GTRPTAGQAA 840
  841 PPSQQPPKPQ EQSRRFSLNL GGITDAPKSQ PTTPQETVTG KLFGFGASIF SQASNLISTA 900
  901 GQQGPHPQTG PAAPSKQAPT PSQSPAAQGP AKSTGQLPPA PAKATAVKKE AKAAAAENLE 960
  961 SKPEQAPTAK KTEKDKKPPP AKVGKPPPSE PEKAVPAHKP DKTTKPKPAC PLCRTELNLG1020
 1021 SQEPPNFNTC TECKNQVCNL CGFNPTPHLT EIQEWLCLNC QTQRAISGQL GDMGKMPPAP1080
 1081 SGPKASPMPA PAEPSSQKTP TGTQVKGKKK EAEGKTEAEK PVPEKETASI EKTPPMVTTD1140
 1141 QKLEESEGKK SKVSALPEKK PSEEEKAISA DKKERKPPAE EKPPLEEKKP IPVDKKLPPE1200
 1201 AKPLSSEGEE KHEILKAHVQ IPEEEPTGKV AAKAGEEEQQ PDSRPEALPG ATPLTLPKAG1260
 1261 EKERAVAQPQ AEGSSKDGQG ERSKEKTEKE EDKSDTSSSQ QPKSPQGLSD TGYSSDGISG1320
 1321 SLGEIPSLIP SDEKDLLKGL KKDSFSQESS PSSPSDLAKL ESTVLSILEA QASTLVGEKA1380
 1381 EKKTQPQKIS PEKPQDQQKT QTASETLDIT ISEEEIKESQ EKKVSPKKDS EQGFPSRKEH1440
 1441 KEKPELVDDL SPRRASYDSV EDSSESENSP VVRRKRRTSI GSSSSDEYKQ EDSQGSGEEE1500
 1501 DFIRKQIIEM SADEDASGSE DEEFIRSQLK EISGVGESQK REEAKGKGKG VAGKHRRLTR1560
 1561 KSSTSFDDDA GRRHSWHDED DETFDESPEL KFRETKSQES EELVVAGGGG LRRFKTIELN1620
 1621 STIADKYSSE SSQKKTILYF DEEPELEMES LTDSPEDRSR GEGSSSLHAS SFTPGTSPTS1680
 1681 VSSLDEDSDS SPSHKKGESK QQRKARHRSH GPLLPTIEDS SEEEELREEE ELLKEQEKQR1740
 1741 ELEQQQRKSS SKKSKKDKDE LRAQRRRERP KTPPSNLSPI EDASPTEELR QAAEMEELHR1800
 1801 SSCSEYSPSI ESDPEGFEIS PEKIIEVQKV YKLPAAVSLY SPTDEQSVMQ KEGVQKALKS1860
 1861 AEEMYEEMMQ KPHKYKAFPA ANERDEVFEK EPLYGGMLIE DYIYESLVED TYNGSVDGSL1920
 1921 LTRQEEQNGF MQQRGREQKV RLQEQIYDDP MQKISDLQKE FYELESLHSV VPQEDIVSSS1980
 1981 YIIPESHEIV DLGSMVMSTS EEKKLLDADS AYEELMRRQQ VQVTDGSSPV QTTIGDDMAE2040
 2041 STLDFDRVQD ASLTSSILSG ASLTDSTSSA TLSIPDVKIT QQFSAEELED EYVTDYTREI2100
 2101 QDIIAHESLI LTYSEPSESA TSVPPSDTPS LTSSISSVCT TDSSSPVTTL DSLTTVYTEP2160
 2161 ADVMTKFKDS EEISSTYFPG SIIDYPEDIS VSLDRTIMPE SRTNEDRIVL SFSGMAPSVV2220
 2221 ESVGTKPERP QADTISTDLP ISEKDLIKGK KETGDGIILE VLDAYKDKRE ESEAELTKIS2280
 2281 LPEPGLAQAP SSVTAPQIKE QHVSPHSVSG KISGQEKPTY RLPSGSLPVS THPSKSRPFF2340
 2341 RSSSLDISAQ PPPPPPPPPP SPSTSSPPPT PPLPPATSPK PPTYPKKKLA VAATVTSTTI2400
 2401 VTTHVDALTM VEAAAARRSN GLPATKMCAI APPPVPPKPS QIPTGLVFTH RPEAIKPPIA2460
 2461 PKPAVPQIPV TTQKPTDTCP KPTGLSLTST MSLNLVTSAD YNVPSPTSPL SPHSNKSSPR2520
 2521 YSKSLMDTYV VITLPSEPGT PTDSSAAQAI TSWPLGSPPK DLVSLETVFS VVPPMTSTEI2580
 2581 PSASQPTLYT SGALGTFSVT PAVTASLFQT VPTSLTQFLP AEASKPEVSA VSSAVPSVAP2640
 2641 RSVSIPIPPE PLALDRHQYK ENGKLPLIGD AIDLRTIPKS EVKVTEKCMD LSASAMDVKR2700
 2701 QTTANEVYRR QISAVQPSII NLSAASSLGT PVTMDSKTVA VVTCTDTTIY TTGTESQVGI2760
 2761 EHAVTSPLQL TTSKHTELPY RKPSSQAFPT IRDEAPINLS LGPSAQAVTL AVTKPVTVPP2820
 2821 VGVTNGWTDS TLSQGVADGE VVDLSTSKSH RTVVTMDEST SNVVTKIIED DEKPVDLTAG2880
 2881 RRAVCCDMVY TLPFGRSCTA QQPATTLPED RFGYRDDHYQ YDRSGPYGYR GIGGMKPSMS2940
 2941 DTNLPEAGHF FYKSKNAFDY SGGTGAAVDL TSGRVSTGEV MDYSSKTTGP YPETRQVISG3000
 3001 VGISTPQYST ARLTPPPGPQ YGVGSVLRSS NGVVYSSVAT PIPSTFAITT QPGSIFSTTV3060
 3061 RDLSGIPTTD AMTSLSALHQ SQPMPRSYFI TTGASETDIA VTGIDINASL QTITMETLPA3120
 3121 ETMDSVPTLT TASEVFSEVV GEESTLLIVP DEDKQQQQLD LERELLELEK IKQQRFAEEL3180
 3181 EWERQEIQRF REQEKIMVQK KLEELQSMKQ HLLYQQEEER QAQFMMRQET LAQQQLQLEQ3240
 3241 IQQLQQQLHQ QLEEQKLRQI YQYNYDPSGT SSPQTTTEQA ILEGQYAATE GSQFWATEDA3300
 3301 TTTASTVVAI EIPQSQGWYT VQSDGVTQYI APPGILSTVS EIPLTDVVVK EEKQPKKRSS3360
 3361 GAKVRGQYDE MGESVADDPR NLKKIVDSGV QTDDEETADR SYASRRRRTK KSVDTSVQTD3420
 3421 DEDQDEWDMP SRSRRKARTG KYGDSTAEGD KTKPLSKVSS VAVQTVAEIS VQTEPVGTIR3480
 3481 TPSIRARVDA KVEIIKHISA PEKTYKGGSL GCQTETDSDT QSPPYLGATS PPKDKKRPTP3540
 3541 LEIGYSSSHL RADPTVQLAP SPPKSPKVLY SPISPLSPGN ALEPAFVPYE KPLPDDISPQ3600
 3601 KVLHPDMAKV PPASPKTAKM MQRSMSDPKP LSPTADESSR APFQYSEGFT TKGSQTMTAS3660
 3661 GTQKKVKRTL PNPPPEEVST GTQSTYSTMG TASRRRMCRT NTMARAKILQ DIDRELDLVE3720
 3721 RESAKLRKKQ AELDEEEKEI DAKLRYLEMG INRRKEALLK EREKRERAYL QGVAEDRDYM3780
 3781 SDSEVSSTRP SRVESQHGVE RPRTAPQTEF SQFIPPQTQT EAQLVPPTSP YTQYQYSSPA3840
 3841 LPTQAPTPYT QQSHFQQQTL YHQQVSPYQT QPTFQAVATM SFTPQAQPTP TPQPSYQLPS3900
 3901 QMMVIQQKPR QTTLYLEPKI TSNYEVIRNQ PLMIAPVSTD NTYAVSHLGS KYNSLDLRIG3960
 3961 LEERSSMAGS PISSISADSF YADIDHHTSR NYVLIDDIGD ITKGTAALST VFSLHEKDLS4020
 4021 KTDRLLRTTE TRRSQEVTDF LAPLQTSSRL HSYVKADEDP MEDPYELKLL KHQIKQEFRR4080
 4081 GTESLDHLAG LSHYYHADTS YRHFPKSEKY SISRLTLEKQ AAKQLPAAIL YQKQSKHKKS4140
 4141 LIDPKMSKFS PIQESRDLEP DYPTYMSSGT SSIGGISSRA RLLQDDITFG LRKNITDQQK4200
 4201 FMGSSLGSGL GTLGNTIRSA LQDEADKPYS SGSRSRPSSR PSSVYGLDLS IKRDSSSSSL4260
 4261 RLKAQEAEAL DVSFGHSSSS ARTKPTSLPI SQSRGRIPIV AQSSEEESPL SPVGQPMGMA4320
 4321 RAAAGPLPPI SADTRDQFGS SHSLPEVQQH MREESRTRGY DRDIAFIMDD FQHAMSDSEA4380
 4381 YHLRREETDW FDKPRESRLE NGHGLDRKLP ERLVHSRPLS QHQEQILQMN GKTIHYIFPH4440
 4441 ARVKITRDFK DHTGSGNGLG IRIVGGKEIP GHSGEIGAYI AKILPGESAE HTGPLMEGMQ4500
 4501 VLEWNGVPLT SKTYEEVQSI INQQSGEAEI CVRLDLNMLS DSENPQHLEL HEPPKVDKAK4560
 4561 SPGVDPKQLA AELQKVSLQQ SPLVMSSVVE KGSHAHSGPT SAGSSSVPSP GQPGSPSVSK4620
 4621 KKHSSTKPTD GPKAASHPIT GEIQLQINYD LGNLIIHILQ ARNLVPRDNN GYSDPFVKVY4680
 4681 LLPGRGQVMV VQNASAEYKR RTKYVQKSLN PEWNQTVIYK SISMEQLMKK TLEVTVWDYD4740
 4741 RFSSNDFLGE VLIDLSSTSH LDNTPRWYPL KEQTESIDHG KSHSSQNSQQ SPKPSVIKSR4800
 4801 SHGIFPDPSK DMQVPTIEKS HSSPGSSKSS SEGHLRSHGP SRSQSKTSVA QTHLEDAGVA4860
 4861 IAAAEAAVQQ LRIQPTKPTN HRPAESSVST GSSGSSVGSG YSVDSEGSSC VAGEPNLLPI4920
 4921 PRIGKMGQNG QDPVKQPGMG ATDTEGKTQV MGEIKLALKK EMKTDGEQLI VEILQCRNIT4980
 4981 YKFKSPDHLP DLYVKLYVIN ISTQKKVIKK KTRVCRHDRE PSFNETFRFS LSPAGHSLQI5040
 5041 LLFSNGGKFM KKTLIGEACI WLDKVDLRKR IVNWHKLLVS PTQTH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle