Protein Overview: MRE11_RAT

General Information:
Name(s) found:	MRE11_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|9651646\|gb\|AAF91227.1\|AF218574_1 MRE11 [Rattus norvegicus] [NCBI NR] gi\|18203120\|sp\|Q9JIM0.1\|MRE11_RAT RecName: Full=Double-strand break repair protein MRE11A; AltName: Full=MRE11 meiotic recombination 11 homolog A; AltName: Full=MRE11 homolog 1 [NCBI NR] gi\|11560107\|ref\|NP_071615.1\| MRE11 [Rattus norvegicus] [NCBI NR] Double-strand break repair protein MRE11A OS=Rattus norvegicus GN=Mre11a PE=1 SV=1 [Swiss-Prot] (Q9JIM0) Double-strand break repair protein MRE11A (MRE11 homolog 1) [Swiss-Prot] Ensembl_locations(Chr-bp):8-11938283;8-11938283 Double-strand break repair protein MRE11A [hmr_yeast5_DM3-1_pombe.fasta] MRE11 [HMR_022704-rand.fasta] MRE11 [Rattus norvegicus]gi\|9651646\|gb\|AAF91227.1\| MRE11 [Rattus norvegicus]gi\|18203120\|sp\|Q9JIM0\|MR11_RAT Double-strand break repair protein MRE11A (MRE11 homolog 1) [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Double-strand break repair protein MRE11A [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_022279) MRE11 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Double-strand break repair protein MRE11A (MRE11 meiotic recombination 11 homolog A) (MRE11 homolog 1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] MRE11 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11A [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Double-strand break repair protein MRE11A (MRE11 homolog 1) (MRE11 meiotic recombination 11 homolog A) [nr-271106-contam.fasta] Tax_Id=10116 Gene_Symbol=Mre11a Double-strand break repair protein MRE11A [rat-ipi-250309-contam.fasta] Double-strand break repair protein MRE11A OS=Rattus norvegicus GN=Mre11a [011711_HMR.fasta] Double-strand break repair protein MRE11A OS=Rattus norvegicus GN=Mre11a PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
Organism:	Rattus norvegicus
Length:	706 amino acids
Gene Ontology:
Cellular Component:	chromosome, telomeric region [UNKNOWN] nucleus [UNKNOWN][IDA][IEA] nuclear chromatin [IDA] perinuclear region of cytoplasm [IDA] Mre11 complex [TAS] [NOT]nucleolus [UNKNOWN] condensed nuclear chromosome [IDA] nucleoplasm [IDA]
Biological Process:	sister chromatid cohesion [UNKNOWN] heart development [IEP] positive regulation of protein amino acid autophosphorylation [UNKNOWN] cell cycle checkpoint [TAS] reciprocal meiotic recombination [TAS] DNA duplex unwinding [UNKNOWN] telomere maintenance [TAS] positive regulation of kinase activity [UNKNOWN] DNA metabolic process [IEA] negative regulation of DNA endoreduplication [UNKNOWN] meiosis [IEA] double-strand break repair [IEA][TAS]
Molecular Function:	DNA binding [UNKNOWN] protein binding [UNKNOWN][IPI] exonuclease activity [IEA] protein C-terminus binding [UNKNOWN] endonuclease activity [IEA] manganese ion binding [IEA] ATP-dependent DNA helicase activity [UNKNOWN] hydrolase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPTDPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN EVDFILLGGD  60
   61 LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEIISDQSVN FGFSKFPWVN YRDGNLNISI 120
  121 PVFSIHGNHD DPTGADALCA LDVLSCAGFV NHFGRSMSVE KVDISPVLLQ KGSTKLALYG 180
  181 LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL 240
  241 VIWGHEHECK IGPTRNEQQL FYVSQPGSSV VTALSPGETV KKHVGLLRVK GRKMNMQKLP 300
  301 LRTVRQFFME DVVLANHPSL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE RLGNPQQPEK 360
  361 PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR HREQKGKTGE EINFGKLIIK 420
  421 PASEGTTLRV EDLVKQYFQT AEKNVQLSLL TERGMGEAVQ EFVDKEEKDA IEELVKYQLE 480
  481 KTQRFLKERH IDALEDKIDE EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSENAASA 540
  541 FSADDLSFDI TEQTADDSDD SQSAVPSRGR GRGRGRRGGR GQSTAPRGGS QRGRDTGLGI 600
  601 STRGRSSKAT ASTSRNMSII DAFRSTRQQP SRNVATKNYS ETIEVDESDD DDSFPTSSRA 660
  661 DQRWSGTAPS KRMSQSQTAK GVDFESDEDD DDDPFMSGSC PRRNRR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: MRE11_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: