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Protein Overview: RAD50_RAT

General Information:
Name(s) found: RAD50_RAT [Swiss-Prot]
Description(s) found:
Found 14 descriptions.
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  • DNA repair protein RAD50 OS=Rattus norvegicus GN=Rad50 PE=1 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 1312 amino acids

    Gene Ontology:
    Cellular Component: chromosome, telomeric region [IEA]
    nucleus [UNKNOWN][IEA]
    nuclear chromatin [IDA]
    perinuclear region of cytoplasm [IDA]
    pronucleus [UNKNOWN]
    chromosome [IEA]
    Mre11 complex [UNKNOWN][IEA][ISS][TAS]
    inclusion body [IDA]
    nuclear chromosome, telomeric region [UNKNOWN]
    condensed nuclear chromosome [IDA]
    nucleoplasm [IDA]
    Biological Process: DNA repair [UNKNOWN][IEA][ISS]
    reciprocal meiotic recombination [TAS]
    DNA recombination [UNKNOWN][ISS]
    regulation of mitotic recombination [UNKNOWN][ISS]
    telomere maintenance [TAS]
    telomere maintenance via telomerase [UNKNOWN][ISS]
    protein heterooligomerization [IDA]
    cell cycle [IEA]
    meiosis [IEA]
    double-strand break repair [UNKNOWN][ISS][TAS]
    positive regulation of protein amino acid autophosphorylation [UNKNOWN]
    cell cycle checkpoint [TAS]
    DNA duplex unwinding [UNKNOWN]
    positive regulation of kinase activity [UNKNOWN]
    Molecular Function: nucleotide binding [IEA]
    DNA binding [UNKNOWN]
    ATP binding [IEA]
    3'-5' exonuclease activity [UNKNOWN][ISS]
    zinc ion binding [IEA]
    protein binding [UNKNOWN][IPI]
    metal ion binding [IEA]
    nuclease activity [IEA]
    ATP-dependent DNA helicase activity [UNKNOWN]
    protein binding, bridging [UNKNOWN][ISS]
    single-stranded DNA specific endodeoxyribonuclease activity [UNKNOWN][ISS]
    hydrolase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRIEKMSTL GVRSFGIEDK DKQIISFFSP LTILVGPNGA GKTTIIECLK YICTGDFPPG  60
   61 TKGNTFVHDP KVAQETDVRA QIRLQFRDVN GEMVLVQRSM LCSQKSKKTE FKTLEGVITR 120
  121 IKHGEKVSLS SKCAEIDREM ISCLGVSKSV LNNVIFCHQE DSNWPLSEGK ALKQKFDEIF 180
  181 SATRYIKALD TLRQVRQTQG QKVKECQTEL KYLRQNKEKA CEIRDQITSK EAQLASSREI 240
  241 VKAYENELEP LKNRLKEIEH NLSKIMRLDN EIKALDSRKK QMEKDNSELE QKMEKVFQGT 300
  301 DEQLNDLYHN HQRTVREKER RLVDCQRELE KLSKEARLLN QERAELLVEQ GRLQLQADRH 360
  361 QEHIRARDSL IQSLAAHLEL DGFERGPFSE RQIKNFHELV RERQEREAKT ASQLLSDLTD 420
  421 KEALKQRQMD EMRDKKSGLG RMIELKTEIL TKKQTELRNV RNELQQLEGS SDRILELDQE 480
  481 LTKAERELSK AEKNSSIETL KAEILNLQSE KADLDRNLRK LDQEMEQLNH HTTTRTQMEM 540
  541 LTKDKTDKDE QIRKIKSRHS DELTSLLGYF PNKKQLEDWL HSKSKEINQT RDRLAKLNKE 600
  601 LASAEQNKNH INNELKKKEE QLSSYEDKLF DVCGSQDFES DLDRLKEDIE KSSKQRAMLA 660
  661 GATAVYSQFI TQLTDENQSC CPGCQRVFQT EAELQEVISD LQSKLRLAPD KLKSTESELK 720
  721 KKERRRDEML GLVPMRQSII DLKEKEIPEL RNRLQSVNRD IQRLKNDIEE QETLLGTVMP 780
  781 EEESAKVCLT DVTIMERFQM ELKDVERKIA QQAAKLQGVD LDRTVQQVNQ EKQEKQHKLD 840
  841 TVSSKIELNR KLIQDQQEQI QHLKSKTNEL KSEKLQIATN LQRRQQMEEQ TVELSTEVQS 900
  901 LNREIKDAKE QINPLEIALE KLQQEKEELI HRKNTSNKMA QDKINDIKEK VKNIHGYMKD 960
  961 IENYIQDGKD DYKKQKETEL NEVVIQLNEC DKHKEKINKE MGTMRQDIDT KKIQERWLQD1020
 1021 NLTLRKRREE LKEVEEERKQ HLKEMGQMQV LQMKNEHQKL EENIDTIKRN HSLALGRQKG1080
 1081 YEEEILHFKK ELREPQFRDA EEKYREMMIV MRTTELVNKD LDIYYKTLDH AIMKFHSMKM1140
 1141 EEINKIIRDL WRSTYRGQDI EYIEIRSDAD ENVSASDKRR NYNYRVVMLK GDTALDMRGR1200
 1201 CSAGQKVLAS LIIRLALAET FCLNCGILAL DEPTTNLDRE NIESLAHALV EIIKSRSQQR1260
 1261 NFQLLVITHD EDFVELLGRS EYVEKFYRVK KNIDQCSEIV KSSINSLGSY VH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle