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Protein Overview: MADD_RAT

General Information:
Name(s) found: MADD_RAT [Swiss-Prot]
Description(s) found:
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  • gi|81861041|sp|O08873.1|MADD_RAT RecName: Full=MAP kinase-activating death domain protein; AltName: Full=Rab3 GDP/GTP exchange factor [NCBI NR]
  • pir||T31671 Rab3 GDP/GTP exchange protein - rat [NCBI NR]
  • gi|1947050|gb|AAC53149.1| Rab3 GDP/GTP exchange protein [Rattus norvegicus] [NCBI NR]
  • gi|16758360|ref|NP_446037.1| MAP-kinase activating death domain [Rattus norvegicus] [NCBI NR]
  • gi|149022617|gb|EDL79511.1| MAP-kinase activating death domain, isoform CRA_c [Rattus norvegicus] [NCBI NR]
  • MAP kinase-activating death domain protein OS=Rattus norvegicus GN=Madd PE=1 SV=1 [Swiss-Prot]
  • Ensembl_locations(Chr-bp):3-69153680;3-69153680;3-69153680;3-69153680 Rab3 GDP/GTP exchange protein [hmr_yeast5_DM3-1_pombe.fasta]
  • MAP-kinase activating death domain; Rab3 GDP/GTP exchange protein [HMR_022704-rand.fasta]
  • MAP-kinase activating death domain [Rattus norvegicus]gi|7514061|pir||T31671 Rab3 GDP/GTP exchange protein - ratgi|1947050|gb|AAC53149.1| Rab3 GDP/GTP exchange protein [Rattus norvegicus] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Rab3 GDP/GTP exchange protein [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta]
  • (NM_053585) MAP-kinase activating death domain; Rab3 GDP/GTP exchange protein [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • MAP kinase-activating death domain protein (Rab3 GDP/GTP exchange factor) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • MAP-kinase activating death domain [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • MAP-kinase activating death domain, isoform CRA_c [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Rab3 GDP/GTP exchange protein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 RAB3 GDP/GTP EXCHANGE PROTEIN [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=10116 Gene_Symbol=Madd MAP kinase-activating death domain protein [rat-ipi-250309-contam.fasta]
  • MAP kinase-activating death domain protein OS=Rattus norvegicus GN=Madd [011711_HMR.fasta]
    • Organism: Rattus norvegicus
    Length: 1602 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    integral to membrane [UNKNOWN][ISS]
    Biological Process: activation of MAPK activity [UNKNOWN][ISS]
    regulation of apoptosis [UNKNOWN][ISS]
    regulation of cell cycle [UNKNOWN][ISS]
    Molecular Function: protein binding [UNKNOWN]
    guanyl-nucleotide exchange factor activity [IEA]
    Rab guanyl-nucleotide exchange factor activity [UNKNOWN][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQKKFCPRL LDYLVIVGAR HPSSDSVAQT PELLRRYPLE DHPEFPLPPD VVFFCQPEGC  60
   61 LSVRQRRMSL RDDTSFVFTL TDKDTGVTRY GICVNFYRSF QKRMPKEKAE GGAGPRGKEG 120
  121 AHAPCASEEA ATESSESGST LQPPSADSTP DVNQSPRGKR RAKAGNRSRN STLTSLCVLS 180
  181 HYPFFSTFRE CLYTLKRLVD CCSERLLGKK PGIPRGVQRD TMWRIFTGSL LVEEKSSALL 240
  241 HDLREIEAWI YRLLRSPVPV SGQKRVDIEV LPQEVQQALT FALPDPSRFT LVDFPLHLPL 300
  301 ELLGVDACLQ VLTCILLEHK VVLQSRDYNA LSMSVMAFVA MIYPLEYMFP VIPLLPTCMA 360
  361 SAEQLLLAPT PYIIGVPASF FLYKLDFKMP DDVWLVDLDS NRVIAPTNAE VLPILPEPES 420
  421 LELKKHLKQA LASMSLNTQP ILNLEKFHEG QETPLLLGRF SNDLQSTPST EFNPLIYGND 480
  481 VDSVDVATRV AMVRFFNSAN VLQGFQMHTR TLRLFPRPVV AFQAGSFLAS RPRQTPFAEK 540
  541 LARTQAVEYF GEWILNPSNY AFQRIHNNTF DPALIGDKPK WYAHQLQPIH YRVYDSNSQL 600
  601 AEALSVPPER DSESDPTDDS GSDSMDYDDS SSSYSSLGDF VSEMMKCDIN GDTPNVDPLT 660
  661 HAALGDASEV EIDELQPQKE GEEPGPDSEN SQENLPLRSS SSTTASSSPS TIVHGAHSEP 720
  721 ADSTEVGDKA ATGISKPLPP VPPSICKSTV DRRQTETGEG SVCQRTYDHP YFEPQYGSPA 780
  781 EEDDDEQGES YTPRFSQHAS GSRAQKLLRP NSLKLASDSD AESDSRASSP NSTVSNNSTE 840
  841 GFGGIMSFAS SLYRNHSTSF SLSNLTLPTK GAREKTTPFP SLKGNRRALV DQKSSVIKHS 900
  901 PTVKREPPSP QGRSSNSSEN QQFLKEVVHS VLDGQGVGWL NMKKVRRLLE SEQLRVFVLS 960
  961 KLSRAVQSED DARQDVIQDV EISRKVYKGM LDLLKCTVLS LEQSYAHAGL GGMASIFGLL1020
 1021 EIAQTHYYSK EPDKRKRSPT ENVNTPVGKD PGLAGRGDPK AMAQLRVPQL GPRAPSATGR1080
 1081 GPKELDTRSL KEENFVASVG PEVIKPVFDL GETEEKKSQI SADSGVSLAS ASQRTDQDSV1140
 1141 IGVSPAVMIR SSSQDSEVSN SSGETLGADS DLSSNAGDGP GGEGSAHLAS SRATLSDSEI1200
 1201 ETNSATSTIF GKAHSLKPKE KPASSPVRSS EDVSQRVYLY EGLLGRDKGS MWDQLEDAAM1260
 1261 ETFSISKERS TLWDQMQFWE DAFLDAVMLE REGMGMDQGP QEMIDRYLSL GEHDRKRLED1320
 1321 DEDRLLATLL HNLISYMLLM KVNKNDIRKK VRRLMGKSHV GLVYSQQINE VLDQLTNLNG1380
 1381 RDLSIRSSGS RHMKKQTFVV HAGTDTNGDI FFMEVCDDCV VLRSNIGTVY ERWWYEKLIN1440
 1441 MTYCPKTKVL CLWRRNGSET QLNKFYTKKC RELYYCVKDS MERAAARQQS IKPGPELGGE1500
 1501 FPVQDMKTGE GGLLQVTLEG INLKFMHNQV FIELNHIKKC NTVRGVFVLE EFVPEIKEVV1560
 1561 SHKYKTPMAH EICYSVLCLF SYVAAVRSSE EDLRTPPRPV SS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.62

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle