Protein Overview: SC6A1_RAT

General Information:
Name(s) found:	SC6A1_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	pir\|\|ACRTGT gamma-aminobutyric acid transport protein - rat [NCBI NR] gi\|204222\|gb\|AAA63487.1\| GABA transporter protein [NCBI NR] gi\|149036947\|gb\|EDL91565.1\| solute carrier family 6 (neurotransmitter transporter, GABA), member 1, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|149036946\|gb\|EDL91564.1\| solute carrier family 6 (neurotransmitter transporter, GABA), member 1, isoform CRA_a [Rattus norvegicus] [NCBI NR] gi\|13242269\|ref\|NP_077347.1\| GABA transporter protein [Rattus norvegicus] [NCBI NR] gi\|128609\|sp\|P23978.1\|SC6A1_RAT RecName: Full=Sodium- and chloride-dependent GABA transporter 1; Short=GAT-1; AltName: Full=Solute carrier family 6 member 1 [NCBI NR] Sodium- and chloride-dependent GABA transporter 1 OS=Rattus norvegicus GN=Slc6a1 PE=1 SV=1 [Swiss-Prot] (P23978) Sodium- and chloride-dependent GABA transporter 1 [Swiss-Prot] Ensembl_locations(Chr-bp):4-155535109 Sodium- and chloride-dependent GABA transporter 1 [hmr_yeast5_DM3-1_pombe.fasta] GABA transporter protein [HMR_022704-rand.fasta] solute carrier family 6 (neurotransmitter transporter, GABA), member 1 [Mus musculus]gi\|13242269\|ref\|NP_077347.1\| GABA transporter protein [Rattus norvegicus]gi\|47117844\|sp\|P31648\|S6A1_MOUSE Sodium- and chloride-dependent GABA transporter 1gi\|128609\|sp [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Sodium- and chloride-dependent GABA transporter 1 [EBI-IPI_rat_3.17_05-10-2006_con_reversed.fasta] (NM_024371) GABA transporter protein [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] Sodium- and chloride-dependent GABA transporter 1 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] GABA transporter protein [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] solute carrier family 6 (neurotransmitter transporter, GABA), member 1, isoform CRA_a [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Slc6a1 Sodium- and chloride-dependent GABA transporter 1 [rat-ipi-250309-contam.fasta] Sodium- and chloride-dependent GABA transporter 1 OS=Rattus norvegicus GN=Slc6a1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	599 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [IEA] synaptosome [IDA] plasma membrane [IDA] axon [UNKNOWN][IEA]
Biological Process:	response to organic substance [IMP] response to purine [IMP] gamma-aminobutyric acid import [IDA] response to cocaine [IEP] protein homooligomerization [IDA] response to organic cyclic substance [IEP] learning [IMP] response to toxin [IMP] response to sucrose stimulus [IEP] neurotransmitter transport [IEA] negative regulation of synaptic transmission, GABAergic [IMP] response to calcium ion [IEP] response to estradiol stimulus [IEP] response to lead ion [IEP] response to organic nitrogen [IEP]
Molecular Function:	neurotransmitter:sodium symporter activity [IEA] protein binding [IDA] symporter activity [IEA] gamma-aminobutyric acid:sodium symporter activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATDNSKVAD GQISTEVSEA PVASDKPKTL VVKVQKKAGD LPDRDTWKGR FDFLMSCVGY  60
   61 AIGLGNVWRF PYLCGKNGGG AFLIPYFLTL IFAGVPLFLL ECSLGQYTSI GGLGVWKLAP 120
  121 MFKGVGLAAA VLSFWLNIYY IVIISWAIYY LYNSFTTTLP WKQCDNPWNT DRCFSNYSLV 180
  181 NTTNMTSAVV EFWERNMHQM TDGLDKPGQI RWPLAITLAI AWVLVYFCIW KGVGWTGKVV 240
  241 YFSATYPYIM LIILFFRGVT LPGAKEGILF YITPNFRKLS DSEVWLDAAT QIFFSYGLGL 300
  301 GSLIALGSYN SFHNNVYRDS IIVCCINSCT SMFAGFVIFS IVGFMAHVTK RSIADVAASG 360
  361 PGLAFLAYPE AVTQLPISPL WAILFFSMLL MLGIDSQFCT VEGFITALVD EYPRLLRNRR 420
  421 ELFIAAVCIV SYLIGLSNIT QGGIYVFKLF DYYSASGMSL LFLVFFECVS ISWFYGVNRF 480
  481 YDNIQEMVGS RPCIWWKLCW SFFTPIIVAG VFLFSAVQMT PLTMGSYVFP KWGQGVGWLM 540
  541 ALSSMVLIPG YMAYMFLTLK GSLKQRLQVM IQPSEDIVRP ENGPEQPQAG SSASKEAYI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: SC6A1_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: