Protein Overview: XRN1

General Information:
Name(s) found:	XRN1 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|74714582\|sp\|Q8IZH2.1\|XRN1_HUMAN RecName: Full=5'-3' exoribonuclease 1; AltName: Full=Strand-exchange protein 1 homolog [NCBI NR] gi\|24474444\|gb\|AAN11306.1\| DNA strand-exchange protein SEP1 [Homo sapiens] [NCBI NR] gi\|119599377\|gb\|EAW78971.1\| 5'-3' exoribonuclease 1, isoform CRA_a [Homo sapiens] [NCBI NR] gi\|110624792\|ref\|NP_061874.3\| 5'-3' exoribonuclease 1 isoform a [Homo sapiens] [NCBI NR] 5'-3' exoribonuclease 1 [HGNC (HUGO)] 5'-3' exoribonuclease 1 OS=Homo sapiens GN=XRN1 PE=1 SV=1 [Swiss-Prot] strand-exchange protein 1 [hmr_yeast5_DM3-1_pombe.fasta] DNA strand-exchange protein SEP1 [Homo sapiens] [nrdb_11152004_Chlamydomonas] Tax_Id=9606 Splice Isoform 1 of 5'-3' exoribonuclease 1 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] 5'-3' exoribonuclease 1 isoform a [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] 5'-3' exoribonuclease 1 (Strand-exchange protein 1 homolog) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] 5'-3' exoribonuclease 1, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 Isoform 1 of 5'-3' exoribonuclease 1 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta] Tax_Id=9606 DNA STRAND-EXCHANGE PROTEIN SEP1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] RecName: Full=5'-3' exoribonuclease 1; AltName: Full=Strand-exchange protein 1 homolog [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=XRN1 Isoform 1 of 5'-3' exoribonuclease 1 [human-ipi-250309-contam.fasta] IPI:IPI00657805.1\|SWISS-PROT:Q8IZH2-1\|ENSEMBL:ENSP00000264951\|REFSEQ:NP_061874\|H-INV:HIT000084697\|VEGA:OTTHUMP00000173105 Tax_Id=9606 Gene_Symbol=XRN1 Isoform 1 of 5'-3' exoribonuclease 1 [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=XRN1 Isoform 1 of 5'-3' exoribonuclease 1 ENSG00000114127 IPI00657805 IPI00657645 IPI00328115 IPI00794052 IPI00795868 IPI00792899 [drosphohumanreversed.fasta] Q8IZH2;Q4G0S3;Q68D88;Q6AI24;Q6MZS8;Q86WS7;Q8N8U4;Q9UF39; RecName: Full=5'-3' exoribonuclease 1; AltName: Full=Strand-exchange protein 1 homolog; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Isoform 1 of 5'-3' exoribonuclease 1 OS=Homo sapiens GN=XRN1 [011711_HMR.fasta] GeneSymbol=XRN1 Synonyms=DKFZp434P0721\|DKFZp686B22225\|DKFZp686F19113\|FLJ41903\|SEP1 5'-3' exoribonuclease 1 isoform a [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] IPI:IPI00657805.1\|SWISS-PROT:Q8IZH2-1\|ENSEMBL:ENSP00000264951\|REFSEQ:NP_061874\|H-INV:HIT000084697\|VEGA:OTTHUMP00000214507 Tax_Id=9606 Gene_Symbol=XRN1 Isoform 1 of 5'-3' exoribonuclease 1 [ipi.HUMAN.20110912.fasta] 5'-3' exoribonuclease 1 GN=XRN1 [Doctor+uniprot-HUMAN-120911.fasta]
Organism:	Homo sapiens
Length:	1706 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVPKFYRWI SERYPCLSEV VKEHQIPEFD NLYLDMNGII HQCSHPNDDD VHFRISDDKI  60
   61 FTDIFHYLEV LFRIIKPRKV FFMAVDGVAP RAKMNQQRGR RFRSAKEAED KIKKAIEKGE 120
  121 TLPTEARFDS NCITPGTEFM ARLHEHLKYF VNMKISTDKS WQGVTIYFSG HETPGEGEHK 180
  181 IMEFIRSEKA KPDHDPNTRH CLYGLDADLI MLGLTSHEAH FSLLREEVRF GGKKTQRVCA 240
  241 PEETTFHLLH LSLMREYIDY EFSVLKEKIT FKYDIERIID DWILMGFLVG NDFIPHLPHL 300
  301 HINHDALPLL YGTYVTILPE LGGYINESGH LNLPRFEKYL VKLSDFDREH FSEVFVDLKW 360
  361 FESKVGNKYL NEAAGVAAEE ARNYKEKKKL KGQENSLCWT ALDKNEGEMI TSKDNLEDET 420
  421 EDDDLFETEF RQYKRTYYMT KMGVDVVSDD FLADQAACYV QAIQWILHYY YHGVQSWSWY 480
  481 YPYHYAPFLS DIHNISTLKI HFELGKPFKP FEQLLAVLPA ASKNLLPACY QHLMTNEDSP 540
  541 IIEYYPPDFK TDLNGKQQEW EAVVLIPFID EKRLLEAMET CNHSLKKEER KRNQHSECLM 600
  601 CWYDRDTEFI YPSPWPEKFP AIERCCTRYK IISLDAWRVD INKNKITRID QKALYFCGFP 660
  661 TLKHIRHKFF LKKSGVQVFQ QSSRGENMML EILVDAESDE LTVENVASSV LGKSVFVNWP 720
  721 HLEEARVVAV SDGETKFYLE EPPGTQKLYS GRTAPPSKVV HLGDKEQSNW AKEVQGISEH 780
  781 YLRRKGIIIN ETSAVVYAQL LTGRKYQINQ NGEVRLEKQW SKQVVPFVYQ TIVKDIRAFD 840
  841 SRFSNIKTLD DLFPLRSMVF MLGTPYYGCT GEVQDSGDVI TEGRIRVIFS IPCEPNLDAL 900
  901 IQNQHKYSIK YNPGYVLASR LGVSGYLVSR FTGSIFIGRG SRRNPHGDHK ANVGLNLKFN 960
  961 KKNEEVPGYT KKVGSEWMYS SAAEQLLAEY LERAPELFSY IAKNSQEDVF YEDDIWPGEN1020
 1021 ENGAEKVQEI ITWLKGHPVS TLSRSSCDLQ ILDAAIVEKI EEEVEKCKQR KNNKKVRVTV1080
 1081 KPHLLYRPLE QQHGVIPDRD AEFCLFDRVV NVRENFSVPV GLRGTIIGIK GANREADVLF1140
 1141 EVLFDEEFPG GLTIRCSPGR GYRLPTSALV NLSHGSRSET GNQKLTAIVK PQPAVHQHSS1200
 1201 SSSVSSGHLG ALNHSPQSLF VPTQVPTKDD DEFCNIWQSL QGSGKMQYFQ PTIQEKGAVL1260
 1261 PQEISQVNQH HKSGFNDNSV KYQQRKHDPH RKFKEECKSP KAECWSQKMS NKQPNSGIEN1320
 1321 FLASLNISKE NEVQSSHHGE PPSEEHLSPQ SFAMGTRMLK EILKIDGSNT VDHKNEIKQI1380
 1381 ANEIPVSSNR RDEYGLPSQP KQNKKLASYM NKPHSANEYH NVQSMDNMCW PAPSQIPPVS1440
 1441 TPVTELSRIC SLVGMPQPDF SFLRMPQTMT VCQVKLSNGL LVHGPQCHSE NEAKEKAALF1500
 1501 ALQQLGSLGM NFPLPSQVFA NYPSAVPPGT IPPAFPPPTG WDHYGSNYAL GAANIMPSSS1560
 1561 HLFGSMPWGP SVPVPGKPFH HTLYSGTMPM AGGIPGGVHN QFIPLQVTKK RVANKKNFEN1620
 1621 KEAQSSQATP VQTSQPDSSN IVKVSPRESS SASLKSSPIA QPASSFQVET ASQGHSISHH1680
 1681 KSTPISSSRR KSRKLAVNFG VSKPSE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.96

Protein Overview: XRN1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: