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Protein Overview: EIF4A3

General Information:
Name(s) found: EIF4A3 [HGNC (HUGO)]
Description(s) found:
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  • gi|7661920|ref|NP_055555.1| eukaryotic translation initiation factor 4A, isoform 3 [Homo sapiens] [NCBI NR]
  • gi|48145617|emb|CAG33031.1| DDX48 [Homo sapiens] [NCBI NR]
  • gi|20532400|sp|P38919.4|IF4A3_HUMAN RecName: Full=Eukaryotic initiation factor 4A-III; AltName: Full=Eukaryotic translation initiation factor 4A isoform 3; AltName: Full=ATP-dependent RNA helicase eIF4A-3; AltName: Full=ATP-dependent RNA helicase DDX48; A [NCBI NR]
  • gi|158254648|dbj|BAF83297.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|15029856|gb|AAH11151.1| Eukaryotic translation initiation factor 4A, isoform 3 [Homo sapiens] [NCBI NR]
  • gi|13325146|gb|AAH04386.1| Eukaryotic translation initiation factor 4A, isoform 3 [Homo sapiens] [NCBI NR]
  • gi|13177790|gb|AAH03662.1| Eukaryotic translation initiation factor 4A, isoform 3 [Homo sapiens] [NCBI NR]
  • gi|119609991|gb|EAW89585.1| DEAD (Asp-Glu-Ala-Asp) box polypeptide 48, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|119609990|gb|EAW89584.1| DEAD (Asp-Glu-Ala-Asp) box polypeptide 48, isoform CRA_a [Homo sapiens] [NCBI NR]
  • eukaryotic translation initiation factor 4A3 [HGNC (HUGO)]
  • Eukaryotic initiation factor 4A-III OS=Homo sapiens GN=EIF4A3 PE=1 SV=4 [Swiss-Prot]
  • Probable ATP-dependent RNA helicase DDX48 (EC 3.6.1.-) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3) - Homo sapiens (Human) [Swiss-Prot]
  • (P38919) Probable ATP-dependent helicase DDX48 (DEAD-box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3) [Swiss-Prot]
  • Eukaryotic initiation factor 4A-like NUK-34 [hmr_yeast5_DM3-1_pombe.fasta]
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; eukaryotic initiation factor 4A-like NUK-34 [HMR_022704.fasta]
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 [Homo sapiens]gi|13177790|gb|AAH03662.1| DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 [Homo sapiens]gi|15029856|gb|AAH11151.1| DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 [Homo sapiens]gi|13325146|gb|AAH04386.1| DEA [nrdb_11152004_Chlamydomonas]
  • Probable ATP-dependent helicase DDX48 (DEAD-box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Probable ATP-dependent RNA helicase DDX48 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_014740) KIAA0111 gene product [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Probable ATP-dependent helicase DDX48 [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta]
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; eukaryotic initiation factor 4A-like NUK-34 [Homo sapiens] [HumanGallus06162005.fasta]
  • Eukaryotic initiation factor 4A-III (Eukaryotic translation initiation factor 4A isoform 3) (ATP-dependent RNA helicase eIF4A-3) (ATP-dependent RNA helicase DDX48) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • eukaryotic translation initiation factor 4A, isoform 3 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 48, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Eukaryotic translation initiation factor 4A, isoform 3 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • DDX48 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 PROBABLE ATP-DEPENDENT HELICASE DDX48 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Eukaryotic initiation factor 4A-III; AltName: Full=Eukaryotic translation initiation factor 4A isoform 3; AltName: Full=ATP-dependent RNA helicase eIF4A-3; AltName: Full=ATP-dependent RNA helicase DDX48; AltName: Full=DEAD box protein 48; Al [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=EIF4A3 Eukaryotic initiation factor 4A-III [human-ipi-250309-contam.fasta]
  • Probable ATP-dependent RNA helicase DDX48 (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Nuclear matrix protein 265) (hNMP 265) (Eukaryotic translation initiation factor 4A isoform 3) [nr-271106-contam.fasta]
  • IPI:IPI00009328.4|SWISS-PROT:P38919|ENSEMBL:ENSP00000269349|REFSEQ:NP_055555|H-INV:HIT000281989|VEGA:OTTHUMP00000181437 Tax_Id=9606 Gene_Symbol=EIF4A3 Eukaryotic initiation factor 4A-III [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=EIF4A3 Eukaryotic initiation factor 4A-III ENSG00000141543 IPI00009328 [drosphohumanreversed.fasta]
  • eukaryotic initiation factor 4A-III [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P38919;Q15033;Q6IBQ2;Q96A18; RecName: Full=Eukaryotic initiation factor 4A-III; AltName: Full=Eukaryotic translation initiation factor 4A isoform 3; AltName: Full=ATP-dependent RNA helicase eIF4A-3; AltName: Full=ATP-dependent RNA helicase DDX48; AltName: Full=DEAD box protein 48; AltName: Full=Eukaryotic initiation factor 4A-like NUK-34; AltName: Full=Nuclear matrix protein 265; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Eukaryotic initiation factor 4A-III OS=Homo sapiens GN=EIF4A3 [011711_HMR.fasta]
  • Eukaryotic initiation factor 4A-III n=25 Tax=Euteleostomi RepID=IF4A3_HUMAN [UniProt_Xenopus_laevis_01-01-2011_reversed.fasta]
  • GeneSymbol=EIF4A3 Synonyms=DDX48|DKFZp686O16189|KIAA0111|MGC10862|NMP265|NUK34|eIF4AIII eukaryotic initiation factor 4A-III [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00009328.4|SWISS-PROT:P38919|ENSEMBL:ENSP00000269349|REFSEQ:NP_055555|H-INV:HIT000281989 Tax_Id=9606 Gene_Symbol=EIF4A3 Eukaryotic initiation factor 4A-III [ipi.HUMAN.20110912.fasta]
  • Eukaryotic initiation factor 4A-III GN=EIF4A3 [Doctor+uniprot-HUMAN-120911.fasta]
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 48, isoform CRA_a OS=Homo sapiens GN=DDX48 PE=3 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 411 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATTATMATS GSARKRLLKE EDMTKVEFET SEEVDVTPTF DTMGLREDLL RGIYAYGFEK  60
   61 PSAIQQRAIK QIIKGRDVIA QSQSGTGKTA TFSISVLQCL DIQVRETQAL ILAPTRELAV 120
  121 QIQKGLLALG DYMNVQCHAC IGGTNVGEDI RKLDYGQHVV AGTPGRVFDM IRRRSLRTRA 180
  181 IKMLVLDEAD EMLNKGFKEQ IYDVYRYLPP ATQVVLISAT LPHEILEMTN KFMTDPIRIL 240
  241 VKRDELTLEG IKQFFVAVER EEWKFDTLCD LYDTLTITQA VIFCNTKRKV DWLTEKMREA 300
  301 NFTVSSMHGD MPQKERESIM KEFRSGASRV LISTDVWARG LDVPQVSLII NYDLPNNREL 360
  361 YIHRIGRSGR YGRKGVAINF VKNDDIRILR DIEQYYSTQI DEMPMNVADL I

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle