Protein Overview: NGLY1

General Information:
Name(s) found:	NGLY1 [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|74732105\|sp\|Q96IV0.1\|NGLY1_HUMAN RecName: Full=Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Short=PNGase; Short=hPNGase; AltName: Full=Peptide:N-glycanase; AltName: Full=N-glycanase 1 [NCBI NR] gi\|21314690\|ref\|NP_060767.2\| N-glycanase 1 isoform 1 [Homo sapiens] [NCBI NR] gi\|20806541\|gb\|AAF74720.2\| PNGase [Homo sapiens] [NCBI NR] gi\|13938211\|gb\|AAH07226.1\| N-glycanase 1 [Homo sapiens] [NCBI NR] gi\|119584769\|gb\|EAW64365.1\| N-glycanase 1, isoform CRA_d [Homo sapiens] [NCBI NR] N-glycanase 1 [HGNC (HUGO)] Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Homo sapiens GN=NGLY1 PE=1 SV=1 [Swiss-Prot] Similar to peptide N-glycanase homolog [hmr_yeast5_DM3-1_pombe.fasta] N-glycanase 1 [Homo sapiens]gi\|13938211\|gb\|AAH07226.1\| N-glycanase 1 [Homo sapiens]gi\|20806541\|gb\|AAF74720.2\| PNGase [Homo sapiens] [nrdb_11152004_Chlamydomonas] Tax_Id=9606 N-glycanase 1 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta] (NM_018297) peptide:N-glycanase similar to yeast PNG1; hypothetical protein FLJ11005 [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] N-glycanase 1 [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta] Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (PNGase) (hPNGase) (Peptide:N-glycanase) (N-glycanase 1) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] N-glycanase 1, isoform CRA_d [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] PNGase [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] Tax_Id=9606 Isoform 1 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta] Tax_Id=9606 N-GLYCANASE 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] RecName: Full=Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Short=PNGase; Short=hPNGase; AltName: Full=Peptide:N-glycanase; AltName: Full=N-glycanase 1 [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta] N-glycanase 1 isoform 1 [Homo sapiens] [NCBI-RefSeq_human-rat_na_04-07-2009_con_reversed.fasta] Tax_Id=9606 Gene_Symbol=NGLY1 Isoform 1 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase [human-ipi-250309-contam.fasta] IPI:IPI00074605.2\|SWISS-PROT:Q96IV0-1\|ENSEMBL:ENSP00000280700\|REFSEQ:NP_060767\|H-INV:HIT000290324\|VEGA:OTTHUMP00000170490;OTTHUMP00000208320 Tax_Id=9606 Gene_Symbol=NGLY1 Isoform 1 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase [ipi.HUMAN.fasta.20090807] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=NGLY1 Isoform 1 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase ENSG00000151092 IPI00385829 IPI00074605 IPI00165496 IPI00784970 IPI00795798 IPI00794500 IPI00784922 IPI00018115 [drosphohumanreversed.fasta] Q96IV0;Q59FB1;Q6PJD8;Q9BVR8;Q9NR70; RecName: Full=Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; AltName: Full=Peptide:N-glycanase; AltName: Full=N-glycanase 1; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Isoform 1 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Homo sapiens GN=NGLY1 [011711_HMR.fasta] GeneSymbol=NGLY1 Synonyms=FLJ11005\|FLJ12409\|PNG1\|PNGase peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform 1 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] IPI:IPI00074605.2\|SWISS-PROT:Q96IV0-1\|ENSEMBL:ENSP00000280700\|REFSEQ:NP_060767\|H-INV:HIT000290324\|VEGA:OTTHUMP00000208320 Tax_Id=9606 Gene_Symbol=NGLY1 Isoform 1 of Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase [ipi.HUMAN.20110912.fasta] Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase GN=NGLY1 [Doctor+uniprot-HUMAN-120911.fasta]
Organism:	Homo sapiens
Length:	654 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAALGSSS GSASPAVAEL CQNTPETFLE ASKLLLTYAD NILRNPNDEK YRSIRIGNTA  60
   61 FSTRLLPVRG AVECLFEMGF EEGETHLIFP KKASVEQLQK IRDLIAIERS SRLDGSNKSH 120
  121 KVKSSQQPAA STQLPTTPSS NPSGLNQHTR NRQGQSSDPP SASTVAADSA ILEVLQSNIQ 180
  181 HVLVYENPAL QEKALACIPV QELKRKSQEK LSRARKLDKG INISDEDFLL LELLHWFKEE 240
  241 FFHWVNNVLC SKCGGQTRSR DRSLLPSDDE LKWGAKEVED HYCDACQFSN RFPRYNNPEK 300
  301 LLETRCGRCG EWANCFTLCC RAVGFEARYV WDYTDHVWTE VYSPSQQRWL HCDACEDVCD 360
  361 KPLLYEIGWG KKLSYVIAFS KDEVVDVTWR YSCKHEEVIA RRTKVKEALL RDTINGLNKQ 420
  421 RQLFLSENRR KELLQRIIVE LVEFISPKTP KPGELGGRIS GSVAWRVARG EMGLQRKETL 480
  481 FIPCENEKIS KQLHLCYNIV KDRYVRVSNN NQTISGWENG VWKMESIFRK VETDWHMVYL 540
  541 ARKEGSSFAY ISWKFECGSV GLKVDSISIR TSSQTFQTGT VEWKLRSDTA QVELTGDNSL 600
  601 HSYADFSGAT EVILEAELSR GDGDVAWQHT QLFRQSLNDH EENCLEIIIK FSDL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..109]	PSI-BLAST	30.69897	No description for 2ccqA was found.
2	View Details	[110..458]	PSI-BLAST	98.0	The Mouse PNGase-HR23 Complex Reveals a Complete Remodulation of the Protein-Protein Interface Compared to its Yeast Orthologs
3	View Details	[459..654]	PSI-BLAST	67.69897	No description for 2g9gA was found.

Protein Overview: NGLY1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: